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抗Mouse (Murine) DAP Kinase 1 抗体:
抗Rat (Rattus) DAP Kinase 1 抗体:
抗Human DAP Kinase 1 抗体:
Human Polyclonal DAP Kinase 1 Primary Antibody for IF (p), IHC (p) - ABIN732983
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
Human Monoclonal DAP Kinase 1 Primary Antibody for IP, MA - ABIN265776
Hearnden, Powers, Elmogassabi, Lowe, Murdoch: Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype. in European journal of nutrition 2017
DAPK deficiency leads to excess HIF-1a (显示 HIF1A 抗体) accumulation, enhanced IL-17 (显示 IL17A 抗体) expression and exacerbated experimental autoimmune encephalomyelitis.
Excitotoxicity can proceed without increased Ser (显示 SIGLEC1 抗体)-1303 phosphorylation, and is unaffected by Dapk1 deficiency in vitro or following ischemia in vivo.
Authors find that the LTP (显示 SCP2 抗体) specificity of CaMKII (显示 CAMK2G 抗体) synaptic accumulation is due to its LTD-specific suppression by calcineurin (CaN)-dependent DAPK1 activation, which in turn blocks CaMKII (显示 CAMK2G 抗体) binding to GluN2B (显示 GRIN2B 抗体).
DAPK1 specifically phosphorylates NDRG2 (显示 NDRG2 抗体) Ser350 and this phosphorylation is an important caspase (显示 CASP3 抗体)-dependent mechanism by which NDRG2 (显示 NDRG2 抗体) mediates cell death in neuronal cells.
Inhibition of DAPK1 by deleting a catalytic domain or a death domain of DAPK1 rescues the Excitatory pyramidal neurons in the entorhinal cortical layer II region synaptic loss
in Alzheimer's disease (AD) brains, elevated DAPK1 levels showed co-relation with the increase of APP (显示 APP 抗体) phosphorylation. Combined together, these results suggest that DAPK1 promotes the phosphorylation and amyloidogenic processing of APP (显示 APP 抗体), and that may serve a potential therapeutic target for AD.
This study demonstrate that phosphorylation of Tau at Serine 262 by the kinase domain of DAPK1 mediates spine damage and the subsequent neuronal death in ischemic stroke.
DAPK1-p53 (显示 TP53 抗体) interaction is a preferred target for therapeutic intervention of stroke.
Suggest that DAPK1 is a novel regulator of tau protein abundance, and that DAPK1 upregulation might contribute to tau-related pathologies in Alzheimer disease.
the DAPK1-p53 (显示 TP53 抗体) interaction is a signaling point of convergence of necrotic and apoptotic pathways
High Promoter Methylation of DAPK1 gene is associated with Breast Cancer.
It is this DAPK1-NR2B (显示 GRIN2B 抗体) interaction that arbitrates the pathological processes like apoptosis, necrosis, and autophagy of neuronal cells observed in stroke injury, hence we aimed to inhibit this vital interaction to prevent neuronal damage.
DNA hypermethylation of DAPK1 gene promoter is a promising biomarker for OSCC prediction/prognostics
rs4878104 T allele could significantly regulate increased DAPK1 expression in European population
the DAPK-mTOR (显示 FRAP1 抗体) pathway is critical for anti-HCV effects of peg (显示 PAEP 抗体)-IFN-alpha (显示 IFNA 抗体)
A significant correlation between changes in the levels of expression and methylation was detected for the three apoptosis-regulatory genes (APAF1 (显示 APAF1 抗体), DAPK1, and BCL2 (显示 BCL2 抗体)). The results suggest that methylation play an important role in the regulation of the apoptosis system genes in breast cancer.
Results show that DNA demethylation of distinct promoter regions is associated with re-expression of the tumor suppressor gene DAPK1. Its knockdown promotes tumor cell migration in breast cancer cell line.
Data show that silencing DNA methyltransferase 1 (DNMT1 (显示 DNMT1 抗体)) increased expression of tumor suppressor genes, RASSF1A (显示 RASSF1 抗体) and DAPK, in esophageal squamous cell carcinoma (ESCC) cells and ESCC xenograft in nude mice.
The current study supports a relevant role for p15 (显示 CDKN2B 抗体), p16, and DAPK hypermethylation in the genesis of the plasma cell neoplasm. DAPK hypermethylation also might be an important step in the progression from MGUS to MM.
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
death-associated protein kinase 1
, death-associated protein kinase 1-like
, DAP kinase 1