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抗Human SYNE2 抗体:
抗Mouse (Murine) SYNE2 抗体:
抗Rat (Rattus) SYNE2 抗体:
Human Monoclonal SYNE2 Primary Antibody for EM, ICC - ABIN1042628
Zhen, Libotte, Munck, Noegel, Korenbaum: NUANCE, a giant protein connecting the nucleus and actin cytoskeleton. in Journal of cell science 2002
Show all 3 Pubmed References
Human Polyclonal SYNE2 Primary Antibody for ELISA, WB - ABIN565027
Maddox, Collin, Ikeda, Pratt, Ikeda, Johnson, Hurd, Shopland, Naggert, Chang, Krebs, Nishina: A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia. in Investigative ophthalmology & visual science 2015
Human Polyclonal SYNE2 Primary Antibody for ICC, IF - ABIN4338643
Versaevel, Braquenier, Riaz, Grevesse, Lantoine, Gabriele: Super-resolution microscopy reveals LINC complex recruitment at nuclear indentation sites. in Scientific reports 2014
variants of EGFR (显示 EGFR 抗体) and SYNE2 play an important role in p21 (显示 CDKN1A 抗体) regulation and are associated with the clinical outcome of HBV-related hepatocellular carcinoma in a TP53 (显示 TP53 抗体)-indenpdent manner
The authors identified the nuclear envelope protein (显示 SUN2 抗体) nesprin-2 as a binding partner for fascin (显示 FSCN1 抗体) in a range of cell types in vitro and in vivo. Nesprin-2 interacts with fascin (显示 FSCN1 抗体) through a direct, F-actin-independent interaction, and this binding is distinct and separable from a role for fascin (显示 FSCN1 抗体) within filopodia at the cell periphery.
these data identify N-terminal nesprin-2 variants as novel regulators of beta-catenin (显示 CTNNB1 抗体) signaling.
We show that AMPH-1 (显示 AMPH 抗体)/BIN1 (显示 BIN1 抗体) binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 (显示 CLIP1 抗体) in both species. We propose that BIN1 (显示 BIN1 抗体) has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies.
nesprin-1 (显示 SYNE1 抗体) and nesprin-2 both regulate nuclear and cytoplasmic architecture.
nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.
Each mutation in LMNA (显示 LMNA 抗体) has a distinct impact on the Nersprin-2 interaction that substantially explains how distinct mutations in widely expressed genes lead to the formation of phenotypically different diseases.
High Nesprin-2 expression is associated with colorectal cancer.
ectopic expression of BRAP2 (显示 BRAP 抗体) inhibits nuclear localization of HMG20A (显示 HMG20A 抗体) and NuMA1, and prevents nuclear envelope accumulation of SYNE2.
Multiple novel nesprin-1 (显示 SYNE1 抗体) and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.
SYNE2 is important for normal retinal development. We have determined that not only is photoreceptor nuclear migration affected, but also the positions of Muller glia and secondary neurons are disturbed early in retinal development
Loss of Nesprin 1 (显示 SYNE1 抗体) or 2, or both, led to impairment of gene expression changes in response to biomechanical stimuli. These data suggest a model whereby biomechanical signals are communicated from proteins of the outer nuclear membrane
ectopic expression of BRAP2 (显示 BRAP 抗体) inhibits nuclear localization of HMG20A (显示 HMG20A 抗体) and NuMA1, and prevents nuclear envelope accumulation of SYNE2
Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus.
functions for Nesprin-2 at the nuclear envelope (NE) in gene regulation and in regulation of the actin cytoskeleton which impact on wound healing
Syne-2, SUN1 (显示 SUN1 抗体) and SUN2 (显示 SUN2 抗体) play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.
The p104 (显示 RB1 抗体) protein interacts with p85alpha and is involved in the regulation of p27(Kip1 (显示 CDKN1B 抗体)) expression for the reduction of cellular proliferation.
The Nesprin-2 the conserved C-terminal amino acids PPPX is essential for the interaction with a C-terminal region in Sun1 (显示 SUN1 抗体).
SUN1 (显示 SUN1 抗体) interacts with nuclear lamin A (显示 LMNA 抗体) and cytoplasmic nesprins (nesprin-1 (显示 SYNE1 抗体) and nesprin-2)to provide a physical connection between the nuclear lamina and the cytoskeleton.
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene.
, nuclear envelope spectrin repeat protein 2
, nuclear envelope spectrin repeat-2
, nucleus and actin connecting element protein
, synaptic nuclear envelope protein 2
, synaptic nuclei expressed gene 2
, spectrin repeat containing, nuclear envelope 2
, synaptic nuclear envelope 2
, LOW QUALITY PROTEIN: nesprin-2