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Human KEAP1 Protein expressed in HEK-293 Cells - ABIN2724103
Lieder, Reisen, Geppert, Sollberger, Beer, auf dem Keller, Schäfer, Detmar, Schneider, Werner: Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening. in The Journal of biological chemistry 2012
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this study shows changes of KEAP1 expression levels induced by cell-free DNA in different cell types
Here we present a proof-of-concept application for the rational design of an epitope-specific antibody binding with the target protein Keap1, by grafting pre-defined structural interaction patterns from the native binding partner protein, Nrf2 (显示 GABPA 蛋白), onto geometrically matched positions of a set of antibody scaffolds. The designed antibodies bind to Keap1 and block the Keap1-Nrf2 (显示 GABPA 蛋白) interaction in an epitope-specific way
our study emphasizes the discovery of a gene signature regulated by the KEAP1-NRF2 (显示 GABPA 蛋白)-CUL3 (显示 CUL3 蛋白) axis which is strongly associated with tumorigenesis and drug resistance in head and neck squamous cell cancer .
In the present review we briefly introduce the Nrf2 (显示 GABPA 蛋白)-Keap1 system and describe Nrf2 (显示 GABPA 蛋白) functions, illustrate the Nrf2 (显示 GABPA 蛋白)-NF-kappaB (显示 NFKB1 蛋白) cross-talk, and highlight the effects of the Nrf2 (显示 GABPA 蛋白)-Keap1 system in the physiology and pathophysiology of striated (显示 NSDHL 蛋白) muscle tissue taking into account its role(s) in oxidative stress and reductive stress
Results show that KEAP1 expression in esophageal squamous cell carcinoma is regulated by miR-432-3p that binds directly its 3'UTR.
An intact complex of PGAM5 (显示 PGAM5 蛋白)-KEAP1-Nrf2 (显示 GABPA 蛋白) preserves mitochondrial motility by suppressing dominant-negative KEAP1 activity.
Hydrogen sulfide (显示 SQRDL 蛋白) attenuates vascular smooth muscle cell calcification in vitro via the KEAP1-NRF2 (显示 GABPA 蛋白) redox sensing/stress response system by enhancing NQO1 (显示 NQO1 蛋白) expression.
Keap1 silencing in melanocytes induced melanogenesis and the expression of melanogenesis-associated molecules through HO-1 (显示 HMOX1 蛋白)-associated beta-catenin (显示 CTNNB1 蛋白) activation. Keap1 downregulation in melanocytes is important for cell proliferation and survival.
itaconate alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 (显示 GABPA 蛋白) to increase the expression of downstream genes with anti-oxidant and anti-inflammatory capacities
ESI (显示 PI3 蛋白) induces protective autophagy of lung cancer cells through Nrf2 (显示 GABPA 蛋白)-p62 (显示 GTF2H1 蛋白)-keap1 feedback loop
By inhibiting binding of Keap1 to Nrf2 (显示 NFE2L2 蛋白).
these studies are the first to demonstrate that Brain ischemic preconditioning protects the blood-brain barrier against ischemic injury by generation of endogenous electrophiles and activation of the Nrf2 (显示 NFE2L2 蛋白) pathway through inhibition of Keap1- and GSK3beta-dependent Nrf2 (显示 NFE2L2 蛋白) degradation.
these results suggested that trehalose can function as a novel activator of the p62 (显示 GTF2H1 蛋白)-Keap1/Nrf2 (显示 NFE2L2 蛋白) pathway, in addition to inducing autophagy. Therefore, trehalose may be useful to treat many chronic diseases involving oxidative stress and dysfunction of autophagy.
While injury tended to suppress these genes in wild-type mice, the suppression was attenuated or reversed in Keap1 hypomorphs, suggesting that protection in these mice was mediated by increased Nrf2 (显示 NFE2L2 蛋白) transcriptional activity.
These findings suggest that Keap1-Nrf2 (显示 NFE2L2 蛋白) system plays a key role in depression and that dietary intake of sulforaphane-rich food during juvenile stages and adolescence can confer stress resilience in adulthood.
these results indicated that inactivation of KEAP1 protein by epigallocatechin gallate may mediate epigallocatechin gallate function in activating NRF2 (显示 NFE2L2 蛋白)
the incidence, multiplicity and burden of Cutaneous squamous cell carcinomas that form in Keap1(flox/flox)/Nrf2 (显示 NFE2L2 蛋白)(-/-) mice are much greater than in their Keap1(flox/flox)/Nrf2 (显示 NFE2L2 蛋白)(+/+) counterparts, establishing Nrf2 (显示 NFE2L2 蛋白) activation as the protection mediator.
The p62 (显示 GTF2H1 蛋白)-keap1-Nrf2 (显示 NFE2L2 蛋白) antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
Keap1 deletion in renal tubular cells results in an abnormal kidney development consistent with hydronephrosis.
serine 351 phosphorylation of p62 (显示 GTF2H1 蛋白) did not enhance its binding to Keap1 or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2 (显示 NFE2L2 蛋白)) transcription factor in this neuronal context. Nrf2 (显示 NFE2L2 蛋白) protein levels were markedly decreased despite transcriptional activation of the Nrf2 (显示 NFE2L2 蛋白) gene
These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 (显示 NFE2L2 蛋白) complex, thereby liberating and activating Nrf2 (显示 NFE2L2 蛋白). Our findings of natural product-derived Nrf2 (显示 NFE2L2 蛋白) activators lead to design options of potent Nrf2 (显示 NFE2L2 蛋白) activators for further optimization.
study reports that the Keap1-Nrf2 (显示 NFE2L2 蛋白) system comprises discrete sensor sites, including the Keap1 cysteines Cys (显示 DNAJC5 蛋白)-151 and Cys (显示 DNAJC5 蛋白)-273, for a variety of Nrf2 (显示 NFE2L2 蛋白)-activating compounds
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2 (显示 NFE2L2 蛋白), indicating that the presence of either Cys (显示 DNAJC5 蛋白)-273 or Cys (显示 DNAJC5 蛋白)-288 is sufficient for fish Keap1 molecules to fully function
the potency of 15d-PGJ2 as a signalling molecule (显示 GDF5 蛋白) in endothelial cells is significantly enhanced by the accumulation of the covalent adduct with 15d-PGJ2 and endogenous Keap1 over the time of exposure to the prostaglandin
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
cytosolic inhibitor of Nrf2
, kelch-like family member 19
, kelch-like protein 19
, NRF2 cytosolic inhibitor
, ring canal protein
, kelch-like ECH-associated protein 1
, LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1