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抗Human G3BP2 抗体:
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Human Polyclonal G3BP2 Primary Antibody for ICC, IF - ABIN4313044
Katz, Sims, Sproul, Caldwell, Dixon, Meehan, Harrison: Targeting of Rac GTPases blocks the spread of intact human breast cancer. in Oncotarget 2012
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Human Polyclonal G3BP2 Primary Antibody for ICC, IF - ABIN4313043
Wei, Fattet, Tsai, Guo, Pai, Majeski, Chen, Sah, Taylor, Engler, Yang: Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. in Nature cell biology 2015
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High G3BP2 levels worsened prognosis in breast cancer. Cell lines with lower G3BP2 levels required substantially higher cell numbers to form tumors in NOD/SCID mice. G3BP2 regulates SART3, Nanog, and Oct-4 expression levels and may be responsible for the maintenance of subpopulations of breast cancer cells with long-term proliferative properties.G3BP2 is important in breast tumor initiation.
Translocation of p53 is regulated by androgen-dependent sumoylation mediated by the G3BP2-interacting SUMO-E3 ligase, RanBP2. G3BP2 knockdown results in reduced tumor growth and increased nuclear p53 accumulation in mouse xenograft models of prostate cancer with or without long-term androgen deprivation.
G3BP mediates the condensation of stress granules by shifting between two different states that are controlled by the phosphorylation of S149 and by binding to Caprin1 or USP10.
FGDF peptide binds and changes conformation of the protruding N-terminal residues by providing hydrophobic interactions to a symmetry related molecule that facilitated crystallization of the G3BP2 isoform.
G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.
Reveal a TWIST1-G3BP2 mechanotransduction pathway that responds to biomechanical signals from the tumour microenvironment to drive EMT, invasion and metastasis.
Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication.
both G3BP1 and G3BP2 play a role in the formation of SGs in various human cells and thereby recovery from these cellular stresses.
Data show that the nsP3/G3BP interaction also blocks stress granules (SGs) induced by other stresses than virus infection.
first evidence of direct interactions between PKCalpha and G3BP2 and that PKCalpha can phosphorylate G3BP2.
We showed that just four genes, G3BP2, SCARB2, CSNK1A1 and SPRR2B, can classify patients as presence of lymph node metastasis negative or positive, with 80.0% accuracy.
Both G3BP1 and G3BP2 isoforms may act as negative regulators of tumor suppressor protein p53.
Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.
Probable scaffold protein that may be involved in mRNA transport (Potential).
ras GTPase-activating protein-binding protein 2
, Ras-GTPase activating protein SH3 domain-binding protein 2
, Ras GTPase-activating protein-binding protein 2
, GTPase activating protein (SH3 domain) binding protein 2
, GAP SH3 domain-binding protein 2
, Ras-GTPase-activating protein (GAP120) SH3-domain binding protein 2
, Ras-GTPase-activating protein (GAP<120>) SH3-domain binding protein 2