Mitogen-Activated Protein Kinase Kinase 4 产品
(Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))
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This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008].
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Featured Mitogen-Activated Protein Kinase Kinase 4 Categories
Mitogen-Activated Protein Kinase Kinase 4 抗体
High quality antibodies with extensive validation data.
Mitogen-Activated Protein Kinase Kinase 4 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Mitogen-Activated Protein Kinase Kinase 4 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Mitogen-Activated Protein Kinase Kinase 4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IHC (p), IP, FACS
Validations
- (8)
Cat. No.
ABIN1499480
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IHC (p), IP
Validations
- (11)
Cat. No.
ABIN1499481
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN1499482
Quantity
100 μL
Datasheet
Datasheet
Recommended Mitogen-Activated Protein Kinase Kinase 4 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380697
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380698
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6219584
Quantity
96 tests
Datasheet
Datasheet
Recommended Mitogen-Activated Protein Kinase Kinase 4 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569654
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124001
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310179
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Mitogen-Activated Protein Kinase Kinase 4 Products
: "Microarray Analysis Identifies the Potential Role of Long Non-Coding RNA in Regulating Neuroinflammation during Japanese Encephalitis Virus Infection." in: Frontiers in immunology, Vol. 8, pp. 1237, (2017) (PubMed).: "High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays." in: Journal of proteome research, Vol. 12, Issue 5, pp. 2311-20, (2013) (PubMed).
: "Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma." in: PLoS ONE, Vol. 7, Issue 1, pp. e30215, (2012) (PubMed).
: "How does arrestin assemble MAPKs into a signaling complex?" in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 685-95, (2008) (PubMed).
: "Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines." in: Molecular cancer research : MCR, Vol. 6, Issue 3, pp. 501-8, (2008) (PubMed).
: "siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle." in: Diabetes, Vol. 57, Issue 8, pp. 2066-73, (2008) (PubMed).
: "Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 5, pp. 3252-8, (2008) (PubMed).
: "Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway." in: The Journal of biological chemistry, Vol. 282, Issue 6, pp. 3507-19, (2007) (PubMed).
: "RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation." in: The Journal of biological chemistry, Vol. 282, Issue 20, pp. 14788-96, (2007) (PubMed).
: "Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases." in: Journal of cancer research and clinical oncology, Vol. 131, Issue 3, pp. 191-8, (2005) (PubMed).
Synonyms and alternative names related to Mitogen-Activated Protein Kinase Kinase 4
mitogen-activated protein kinase kinase 4 (MAP2K4), mitogen-activated protein kinase kinase 4 (Map2k4), mitogen-activated protein kinase kinase 4a (map2k4a), mitogen-activated protein kinase kinase 4 (map2k4), MAP kinase kinase 4 (Mkk4), mitogen activated protein kinase kinase 4 (Map2k4), mitogen-activated protein kinase kinase 4 (MKK4), mitogen-activated protein kinase kinase 4b (map2k4b), 142758_at, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, ATMEK4, ATMKK4, CG9738, CT27508, D-MKK4, Dmel\\CG9738, DMKK4, dMKK4, dMkk4, F19C24.26, F19C24_26, hep, JNKK, jnkk, JNKK1, jnkk1, JNKK2, map2k4, MAP KINASE KINASE 4, MAPKK4, mapkk4, MEK4, mek4, mitogen-activated protein kinase kinase 4, MKK4, mkk4, MKK4A-l, MKK4B, Mpk4, PRKMK4, prkmk4, SAPKK-1, SAPKK1, SEK1, Sek1, sek1, SEK1/MKK4, SERK1, Serk1, serk1, SKK1, xmek2, zgc:136500, zgc:194486Protein level used designations for Mitogen-Activated Protein Kinase Kinase 4
- JNK activating kinase 1
- JNK-activated kinase 1
- JNK-activating kinase 1
- MAP kinase kinase 4
- MAPK/ERK kinase 4
- MAPKK 4
- MEK 4
- SAPK/ERK kinase 1
- c-Jun N-terminal kinase kinase 1
- dual specificity mitogen-activated protein kinase kinase 4
- stress-activated protein kinase kinase 1
- C-JUN N-terminal kinase kinase 1
- JNK kinase 1
- JNKK 1
- SAPK/Erk/kinase 1
- mitogen activated protein kinase kinase 4, variant 1
- mitogen-activated protein kinase kinase 4
- mkk4a
- CG9738-PA
- CG9738-PB
- CG9738-PC
- JNK kinase 2
- Map kinase kinase 4
- Mkk4-PA
- Mkk4-PB
- Mkk4-PC
- drosophila MAP kinase kinase 4
- MAP2K4delta
- MAP kinase kinase 4B
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- MIR7-3HG
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