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PPP1R12A 抗体

(Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
PPP1R12A 抗体  (C-Term) PPP1R12A 抗体  (C-Term) PPP1R12A 抗体 (C-Term) (ABIN6391349)

Verified PPP1R12A 适用: 人 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated

PPP1R12A 抗体  (AA 1-200) PPP1R12A 抗体  (AA 1-200) PPP1R12A 抗体 (AA 1-200) (ABIN6146059)

PPP1R12A 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

PPP1R12A 抗体  (N-Term) PPP1R12A 抗体  (N-Term) PPP1R12A 抗体 (N-Term) (ABIN3043902)

PPP1R12A 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

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Find PPP1R12A 抗体 for a variety of species such as anti-Mouse PPP1R12A, anti-Human PPP1R12A, anti-Rat PPP1R12A. The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular PPP1R12A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF, FACS
Validations
  • (9)
Cat. No. ABIN6391349
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IP
Validations
  • (6)
Cat. No. ABIN6146059
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (1)
  • (7)
Cat. No. ABIN3043902
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (1)
  • (3)
Cat. No. ABIN6263491
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, FACS
Validations
  • (3)
Cat. No. ABIN744068
Quantity 100 μL
Datasheet Datasheet
Reactivity Chicken, Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
  • (2)
Cat. No. ABIN537186
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7182058
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (2)
Cat. No. ABIN6242457
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN3185745
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN3182548
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN6146060
Quantity 100 μL
Datasheet Datasheet
Reactivity Chicken, Human, Mouse, Pig, Rat, Zebrafish (Danio rerio)
Application WB, IHC, IF, IC
Validations
  • (3)
Cat. No. ABIN7303414
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
Cat. No. ABIN744083
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6242461
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6242460
Quantity 200 μL
Datasheet Datasheet

Latest Publications for our PPP1R12A 抗体

Xiaojun, Yan, Hong, Xianghong, Shifeng, Dingjie, Xuemin, Lijuan, Bonan, Zhongqiu, Ruimin, Brann, Fang: "Acetylated α-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica." in: Scientific reports, Vol. 6, pp. 32257, (2018) (PubMed).

Ye, Jing, Li, Wu, Li, Xu: "Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway." in: Biomedicine & pharmacotherapy, Vol. 88, pp. 384-394, (2017) (PubMed).

Yan, Wang, Jiang, Chen, He, Mang, Shao, Xu: "The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral ischemia." in: Neural regeneration research, Vol. 10, Issue 9, pp. 1441-9, (2015) (PubMed).

Lutter, Barger, Nair, Hackstadt: "Chlamydia trachomatis inclusion membrane protein CT228 recruits elements of the myosin phosphatase pathway to regulate release mechanisms." in: Cell reports, Vol. 3, Issue 6, pp. 1921-31, (2013) (PubMed).

Khatri, Joyce, Brozovich, Fisher: "Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37250-7, (2001) (PubMed).

Kimura, Ito, Amano, Chihara, Fukata, Nakafuku, Yamamori, Feng, Nakano, Okawa, Iwamatsu, Kaibuchi: "Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)" in: Science (New York, N.Y.), Vol. 273, Issue 5272, pp. 245-8, (1996) (PubMed).

Chen, Chen, Alessi, Campbell, Shanahan, Cohen, Cohen: "Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M." in: FEBS letters, Vol. 356, Issue 1, pp. 51-5, (1995) (PubMed).

Aliases for PPP1R12A 抗体

protein phosphatase 1, regulatory (inhibitor) subunit 12A (Ppp1r12a) 抗体
protein phosphatase 1 regulatory subunit 12A (PPP1R12A) 抗体
protein phosphatase 1, regulatory subunit 12A (Ppp1r12a) 抗体
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