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mTOR (显示 FRAP1 ELISA试剂盒) and protein phosphatase 2A catalytically control the constitutive nuclear import of latent STAT1 (显示 STAT1 ELISA试剂盒) by KPNA1, which are key modulators of STAT1 (显示 STAT1 ELISA试剂盒) expression and apoptosis.
KPNA1 knockdown increased myoblast proliferation.
Importin alpha binding and the nuclear import of myopodin (显示 SYNPO2 ELISA试剂盒) are regulated by the serine/threonine phosphorylation-dependent binding of myopodin (显示 SYNPO2 ELISA试剂盒) to 14-3-3 (显示 YWHAQ ELISA试剂盒). These results establish a novel paradigm for the promotion of nuclear import by 14-3-3 (显示 YWHAQ ELISA试剂盒) binding.
PTH1R (显示 PTH1R ELISA试剂盒) forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta (显示 KPNB1 ELISA试剂盒), and nuclear PTH1R (显示 PTH1R ELISA试剂盒) is associated with the nucleoplasm
Here, we show that the expression of importin-alpha subtypes is strictly regulated during neural differentiation of mouse embryonic stem (ES) cells, and that the switching of importin-alpha subtype expression is critical for neural differentiation.
Absence of importin a5 during mouse development does not significantly interfere with neuronal differentiation and brain development.
Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin beta1 and importin 7 (显示 IPO7 ELISA试剂盒).
miR (显示 MLXIP ELISA试剂盒)-26b plays an anti-metastatic role and is downregulated in gastric cancer tissues via the KPNA2 (显示 KPNA2 ELISA试剂盒)/c-jun (显示 JUN ELISA试剂盒) pathway
our results show for the first time that KPNA2 (显示 KPNA2 ELISA试剂盒) is transcriptionally and post-translationally regulated by the mTOR (显示 FRAP1 ELISA试剂盒) pathway and provide new insights into targeted therapy for non-small cell lung cancer
KPNA2 (显示 KPNA2 ELISA试剂盒) was associated with tumorigenesis and cancer progression in CRC (显示 CALR ELISA试剂盒) cells; high KPNA2 (显示 KPNA2 ELISA试剂盒) expression was associated with increased cell proliferation, migration, invasion, and semisolid agar colony formation.
that the interactions observed between TNRC6A and importin-alpha are conserved between mouse and human complexes. Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-alpha major binding site, as well as regions outside the main binding cavities.
The authors identified Importin-alpha1 to bind to Coxiella burnetii AnkG and concluded that binding of AnkG to p32 and Importin-alpha1 is essential for its migration into the nucleus.
the crystal structure of the nuclear import adaptor importin-alpha1 bound to the nuclear localization signal (NLS (显示 ALDH1A2 ELISA试剂盒)) of EBNA-LP that shows EBNA-LP residues 44-RRVRRR-49 binding to the major NLS (显示 ALDH1A2 ELISA试剂盒)-binding site at the P0-P5 positions.
High serum karyopherin alpha 2 levels (>485 microg/mL) correlated with International Federation of Gynecology and Obstetrics stage ( p < 0.0001), lymphatic metastasis ( p = 0.045), overall survival ( p = 0.001), and disease-free progression ( p = 0.006). Serum karyopherin alpha 2 represents a potential diagnostic biomarker for epithelial ovarian carcinoma.
p53 (显示 TP53 ELISA试剂盒)/p21Cip1/Waf1 (显示 CDKN1A ELISA试剂盒)/p16INK4a may be an important pathway involved in the function of KPNA2 (显示 KPNA2 ELISA试剂盒) in tongue squamous cell carcinoma (TSCC) CAL (显示 FBLIM1 ELISA试剂盒)-27 cells.
Results demonstrated that radiation-induced dying colorectal cancer cells released considerable amounts of KPNA2 (显示 KPNA2 ELISA试剂盒) that induce the maturation and activation of DCs for synergistic antitumor effect of radiation.
These results suggest that the selected aptamers (76 and 72) warrant further study to explore not only their application in cancer diagnosis but also their use as a specific reagent to potentially block KPNA2 (显示 KPNA2 ELISA试剂盒)-dependent nuclear transport of macromolecules across the nuclear membrane.
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination
, RAG cohort protein 2
, importin alpha-S1
, importin subunit alpha-1
, importin subunit alpha-5
, karyopherin subunit alpha-1
, nucleoprotein interactor 1
, importin alpha 5
, importin alpha-5
, karyopherin (importin) alpha 1
, karyopherin/importin alpha-1
, RAG cohort 1
, RAG cohort protein 1
, importin alpha 1
, importin alpha 2
, importin subunit alpha-2
, karyopherin subunit alpha-2