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SQSTM1 is required for proper dynein motility and trafficking along microtubules.
Study found Dync1i2 has 11 isoforms: six including exon 1a, five including exon 1b; isoforms with the same exon content other than exon 1a and 1b have similar but not identical expression patterns.
Using mouse cells as a model, show that Par3 associates with dynein by interacting with dynein light intermediate chain 2.
This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants.
dynein, cytoplasmic, intermediate chain 1
, uncharacterized protein LOC431853
, dynein, cytoplasmic 1, intermediate chain 2
, cytoplasmic dynein 1 intermediate chain 2
, DH IC-2
, cytoplasmic dynein intermediate chain 2 isoform 2.1
, cytoplasmic dynein intermediate chain 2 isoform 2.2
, cytoplasmic dynein intermediate chain 2 isoform 2.5
, dynein intermediate chain 2, cytosolic
, dynein, cytoplasmic, intermediate chain 2
, cytoplasmic dynein intermediate chain 2
, dynein, cytoplasmic, intermediate polypeptide 2
, oncofetal protein (OFP)