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CDK11 has a role in human cancers [review]
demonstrates that CDK11(p46) directly interacts with RanBPM in vitro and in human cells
the PITSLRE IRES interacts with the Unr protein, which is more prominently expressed at the G2/M stage of the cell cycle
CDK11 kinases could be regulated by interaction with 14-3-3 proteins during cell cycle and apoptosis
CDK11(p58) is a new interacting protein and a novel regulator of histone acetyltransferase (HAT) HBO1.
CDK11p60 can contribute to apoptosis by direct signalling at the mitochondria, thereby amplifying Fas-induced apoptosis in melanoma cells.
These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity.
mitotic CDK11(p58) isoform, but not the CDK11(p110) isoform, associates with mitotic centrosomes
CDC2L2 gene may contribute to the susceptibility of type 2 diabetes in the northern Han Chinese population.
findings show that, in addition to playing a role in spindle formation and structure, CDK11(p58) is also required for sister chromatid cohesion and the completion of mitosis
These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells.
Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.
study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21\\/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far.
, PITSLRE protein kinase beta
, PITSLRE serine/threonine-protein kinase CDC2L2
, cell division cycle 2-like 2 (PITSLRE proteins)
, cell division cycle 2-like protein kinase 2
, cell division protein kinase 11A
, galactosyltransferase-associated protein kinase p58/GTA
, cyclin-dependent kinase 11A
, cyclin-dependent kinase 11B
, cell division cycle 2-like 1 (PITSLRE proteins)
, cell division protein kinase 11
, protein kinase