HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Alias Symbols: ALS10, TDP-43
Protein Interaction Partner: ZFAND2B, TARDBP, UBC, SUMO2, STAU1, SUMO3, RNF4, USP8, RBM45, RNF2, LSM6, UBE2E3, GNB2L1, MED6, RPA1, WWOX, RPA3, RPA2, PARK2, EED, BMI1, RBM39, BAG2, RPL23, DDX21, PRPF3, USP10, SART1, RPL14, H1FX, FUBP3, PABPC4, EIF4G3, EIF3I, EIF3H, EIF3C, EIF3B, EIF3A