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HFE2 ELISA 试剂盒

HFE2 适用: 人 AA 36-400 Colorimetric Sandwich ELISA
产品编号 ABIN5510627
发货至: 中国
  • 抗原 See all HFE2 ELISA试剂盒
    HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
    抗原表位
    AA 36-400
    适用
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
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    检测方法
    Colorimetric
    实验类型
    Sandwich ELISA
    应用范围
    ELISA
    原理
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Hemojuvelin/RGM-C
    品牌
    PicoKine™
    Analytical Method
    Quantitative
    特异性
    Expression system for standard: NSO
    Immunogen sequence: Q36-D400
    交叉反应 (详细)
    There is no detectable cross-reactivity with other relevant proteins.
    产品特性

    Tissue Specificity: Adult and fetal liver, heart, and skeletal muscle. .

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  • 板类型
    Pre-coated
    限制
    仅限研究用
  • 储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    有效期
    12 months
  • 抗原 See all HFE2 ELISA试剂盒
    HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
    别名
    HFE2 (HFE2 产品)
    别名
    HFE2A ELISA Kit, HJV ELISA Kit, JH ELISA Kit, RGMC ELISA Kit, HFE2 ELISA Kit, DKFZp468F2322 ELISA Kit, 2310035L15Rik ELISA Kit, 5230400G09Rik ELISA Kit, AI414844 ELISA Kit, AI789733 ELISA Kit, DL-M ELISA Kit, Rgmc ELISA Kit, hemojuvelin ELISA Kit, RGMr ELISA Kit, hjv ELISA Kit, id:ibd3464 ELISA Kit, wu:fb38f10 ELISA Kit, zgc:136698 ELISA Kit, hemochromatosis type 2 (juvenile) ELISA Kit, hemochromatosis type 2 ELISA Kit, HFE2 ELISA Kit, Hfe2 ELISA Kit, hfe2 ELISA Kit
    背景

    Protein Function: Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. .

    Background: Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of the repulsive guidance molecule family of proteins. In humans, the hemojuvelin protein is encoded by the HFE2 gene. The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

    Synonyms: Hemojuvelin,Hemochromatosis type 2 protein,RGM domain family member C,HFE2,HJV, RGMC,

    Full Gene Name: Hemojuvelin

    Cellular Localisation: Cell membrane, Lipid-anchor, GPI-anchor . Also released in the extracellular space..
    UniProt
    Q6ZVN8
    途径
    Transition Metal Ion Homeostasis
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