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Human Thrombopoietin ELISA Kit for Sandwich ELISA - ABIN625104
Yilmaz, Basar, Altınbas, Ekiz, Aktas, Oztürk, Ginis, Coban, Ucar, Erarslan, Coskun, Yüksel, Tuna, Yüksel: The utility of thrombopoietin in predicting liver fibrosis in chronic hepatitis B. in International journal of clinical and experimental medicine 2014
These studies demonstrate that biallelic loss-of-function mutations in THPO cause bone marrow failure, which is unresponsive to transplant due to a hematopoietic cell-extrinsic mechanism.
Genetically engineered mesenchymal stromal cells produce IL-3 (显示 IL-3 ELISA试剂盒) and TPO to further improve human scaffold-based xenograft models
bone marrow megakaryocytes possess a complete mechanism to synthesize the ECM (显示 MMRN1 ELISA试剂盒) components, and that thrombopoietin is a pivotal regulator of this new function inducing transforming growth factor-b1 (TGF-beta1 (显示 TGFB1 ELISA试剂盒)) release and consequent activation of the downstream pathways, both in vitro and in vivo
High Thrombopoietin expression is associated with immune thrombocytopenia in pregnancy.
Colorectal cancer tumor-initiating cells (TICs) expressing CD110 (显示 MPL ELISA试剂盒), the thrombopoietin (TPO)-binding receptor, mediate liver metastasis. We show that TPO promotes metastasis of CD110 (显示 MPL ELISA试剂盒)+ TICs to the liver by activating lysine degradation.
decreased TPO levels or decreased bone marrow production of platelets may not be a cause of thrombocytopenia in chronic hepatitis C
WASP, RUNX1 (显示 RUNX1 ELISA试剂盒), and ANKRD26 (显示 ANKRD26 ELISA试剂盒) genes are important for normal TPO signaling and the network underlying thrombopoiesis.
Data suggest that elevated serum level of thrombopoietin may serve as unfavorable marker of stage of multiple myeloma.
The regulation of OCs by TPO highlights a novel therapeutic target for bone loss diseases and may be important to consider in the numerous hematologic disorders associated with alterations in TPO/c-mpl (显示 MPL ELISA试剂盒) signaling
TPO was greatly enhanced in HPT in comparison with ITP (显示 ITPA ELISA试剂盒) patients (958 +/- 659 and 11 +/- 27 pg/ml, p < 0.001). In the ITP (显示 ITPA ELISA试剂盒) group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006).
TPO and its receptor Mpl (显示 MPL ELISA试剂盒) are dispensable for platelet survival in adult mice
Thrombopoietin-mediated phosphorylation of STAT5 (显示 STAT5A ELISA试剂盒) triggers its genome-wide relocation to STAT (显示 STAT1 ELISA试剂盒) consensus sites, resulting in loss of a uSTAT5 program that restrains megakaryocytic differentiation and activation of STAT5 (显示 STAT5A ELISA试剂盒)-driven gene expression.
Furthermore, although the contribution of the TPO treated graft to long-term hematological engraftment was reduced, the TPO treated and untreated grafts both contributed significantly to long-term chimerism in vivo.
TPO treatment also promoted the peripheral induction of Foxp3 (显示 FOXP3 ELISA试剂盒)(+) Tregs in conjunction with elevated circulating TGF-beta (显示 TGFB1 ELISA试剂盒) levels.
novel findings about aspects of TPO action on stem cells
Mpl (显示 MPL ELISA试剂盒) expression, but not Tpo, is fundamental in the development of JAK2V617F(+) myeloproliferative neoplasms
Thrombopoietin/MPL (显示 MPL ELISA试剂盒) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (显示 MECOM ELISA试剂盒) leukemia.
Megakaryocytes regulate cell cycle quiescence of hematopoietic stem cell through the production of thrombopoietin.
IEX-1 (显示 IER3 ELISA试剂盒) has a role in activation of Erk (显示 EPHB2 ELISA试剂盒) and NF-kB pathways, which affects thrombopoietin-promoted NHEJ DNA repair in hematopoietic stem cells
Findings establish that Clock regulates Thpo and Mpl (显示 MPL ELISA试剂盒) expression in vivo, and demonstrate an important link between the body's circadian timing mechanisms and megakaryopoiesis.
The results demonstrate the possible involvement of locally produced TPO (显示 TPO ELISA试剂盒)/c-MPL (显示 MPL ELISA试剂盒) system as a 'physiological filter' in bovine ovary where they may promote cell selection by inducing proliferation of viable cells and scavenging non-viable cells.
These studies indicate that the functional role of Tpo in the differentiation of thrombocytes from hematopoietic stem and progenitor cells is well conserved among vertebrate organisms, positing the zebrafish as an excellent model to investigate diseases caused by dysregulated erythro- and thrombo-poietic differentiation.
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.
, c-mpl ligand
, megakaryocyte colony-stimulating factor
, megakaryocyte growth and development factor
, megakaryocyte stimulating factor
, myeloproliferative leukemia virus oncogene ligand
, thrombopoietin nirs variant 1
, C-mpl ligand
, thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)