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抗Human Thrombopoietin 抗体:
抗Mouse (Murine) Thrombopoietin 抗体:
抗Rat (Rattus) Thrombopoietin 抗体:
Human Monoclonal Thrombopoietin Primary Antibody for FACS, ELISA - ABIN969571
Graziano, Carone, Panza, Marino, Magini, Romeo, Pession, Seri: Association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation. in Blood 2009
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Dog (Canine) Polyclonal Thrombopoietin Primary Antibody for WB - ABIN2787808
Baker, Gray, Wright, Fitzsimons, Nimmo, Lowry, Mutrie,: The effect of a pedometer-based community walking intervention "Walking for Wellbeing in the West" on physical activity levels and health outcomes: a 12-week randomized controlled trial. in The international journal of behavioral nutrition and physical activity 2008
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Human Polyclonal Thrombopoietin Primary Antibody for IF (p), IHC (p) - ABIN1714401
Nakamura-Ishizu, Takubo, Kobayashi, Suzuki-Inoue, Suda: CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. in The Journal of experimental medicine 2015
These studies demonstrate that biallelic loss-of-function mutations in THPO cause bone marrow failure, which is unresponsive to transplant due to a hematopoietic cell-extrinsic mechanism.
Genetically engineered mesenchymal stromal cells produce IL-3 (显示 IL-3 抗体) and TPO to further improve human scaffold-based xenograft models
bone marrow megakaryocytes possess a complete mechanism to synthesize the ECM (显示 MMRN1 抗体) components, and that thrombopoietin is a pivotal regulator of this new function inducing transforming growth factor-b1 (TGF-beta1 (显示 TGFB1 抗体)) release and consequent activation of the downstream pathways, both in vitro and in vivo
High Thrombopoietin expression is associated with immune thrombocytopenia in pregnancy.
Colorectal cancer tumor-initiating cells (TICs) expressing CD110 (显示 MPL 抗体), the thrombopoietin (TPO)-binding receptor, mediate liver metastasis. We show that TPO promotes metastasis of CD110 (显示 MPL 抗体)+ TICs to the liver by activating lysine degradation.
decreased TPO levels or decreased bone marrow production of platelets may not be a cause of thrombocytopenia in chronic hepatitis C
WASP, RUNX1 (显示 RUNX1 抗体), and ANKRD26 (显示 ANKRD26 抗体) genes are important for normal TPO signaling and the network underlying thrombopoiesis.
Data suggest that elevated serum level of thrombopoietin may serve as unfavorable marker of stage of multiple myeloma.
The regulation of OCs by TPO highlights a novel therapeutic target for bone loss diseases and may be important to consider in the numerous hematologic disorders associated with alterations in TPO/c-mpl (显示 MPL 抗体) signaling
TPO was greatly enhanced in HPT in comparison with ITP (显示 ITPA 抗体) patients (958 +/- 659 and 11 +/- 27 pg/ml, p < 0.001). In the ITP (显示 ITPA 抗体) group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006).
TPO and its receptor Mpl (显示 MPL 抗体) are dispensable for platelet survival in adult mice
Thrombopoietin-mediated phosphorylation of STAT5 (显示 STAT5A 抗体) triggers its genome-wide relocation to STAT (显示 STAT1 抗体) consensus sites, resulting in loss of a uSTAT5 program that restrains megakaryocytic differentiation and activation of STAT5 (显示 STAT5A 抗体)-driven gene expression.
Furthermore, although the contribution of the TPO treated graft to long-term hematological engraftment was reduced, the TPO treated and untreated grafts both contributed significantly to long-term chimerism in vivo.
TPO treatment also promoted the peripheral induction of Foxp3 (显示 FOXP3 抗体)(+) Tregs in conjunction with elevated circulating TGF-beta (显示 TGFB1 抗体) levels.
novel findings about aspects of TPO action on stem cells
Mpl (显示 MPL 抗体) expression, but not Tpo, is fundamental in the development of JAK2V617F(+) myeloproliferative neoplasms
Thrombopoietin/MPL (显示 MPL 抗体) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (显示 MECOM 抗体) leukemia.
Megakaryocytes regulate cell cycle quiescence of hematopoietic stem cell through the production of thrombopoietin.
IEX-1 (显示 IER3 抗体) has a role in activation of Erk (显示 EPHB2 抗体) and NF-kB pathways, which affects thrombopoietin-promoted NHEJ DNA repair in hematopoietic stem cells
Findings establish that Clock regulates Thpo and Mpl (显示 MPL 抗体) expression in vivo, and demonstrate an important link between the body's circadian timing mechanisms and megakaryopoiesis.
The results demonstrate the possible involvement of locally produced TPO (显示 TPO 抗体)/c-MPL (显示 MPL 抗体) system as a 'physiological filter' in bovine ovary where they may promote cell selection by inducing proliferation of viable cells and scavenging non-viable cells.
These studies indicate that the functional role of Tpo in the differentiation of thrombocytes from hematopoietic stem and progenitor cells is well conserved among vertebrate organisms, positing the zebrafish as an excellent model to investigate diseases caused by dysregulated erythro- and thrombo-poietic differentiation.
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.
, c-mpl ligand
, megakaryocyte colony-stimulating factor
, megakaryocyte growth and development factor
, megakaryocyte stimulating factor
, myeloproliferative leukemia virus oncogene ligand
, thrombopoietin nirs variant 1
, C-mpl ligand
, thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)