蛋白简介

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT3

• signal transducer and activator of transcription 3 (STAT3) 抗体
• signal transduction and activation of transcription 3 (stat3) 抗体
• signal transducer and activator of transcription 3 (stat3) 抗体
• signal transducer and activator of transcription 3 (Stat3) 抗体
• signal transducer and activator of transcription 3, gene 1 L homeolog (stat3.1.L) 抗体
• 显示所有的基因名称
• signal transducer and activator of transcription 3 (acute-phase response factor) (stat3) 抗体

• 1110034C02Rik 抗体
• aprf 抗体
• AW109958 抗体
• hies 抗体
• stat3 抗体
• 显示所有的同义词和别名
• wu:fc15d02 抗体
• wu:fl59g06 抗体
• Xstat3 抗体
• z-Stat3 抗体

Protein level used designations for STAT3

signal transducer and activator of transcription 3 (acute-phase response factor) , signal transducer and activator of transcription 3 , signal transduction and activation of transcription 3 , Signal transducer and activator of transcription 3 , signal transducer and activator of transcription 3-like , acute phase response factor , acute-phase response factor , DNA-binding protein APRF , Protein Stat3 , signal transducer and activator of transcription 3.1 , stat 3