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RANKL (显示 TNFSF11 蛋白) and Src has an unrecognized role in osteocyte survival.
These interactions are required for SRC-induced activation of VAV (显示 VAV1 蛋白) and the subsequent engagement of a JIP1 (显示 MAPK8IP1 蛋白)-tethered JNK (显示 MAPK8 蛋白) signaling module.
Elevated retinoic acid-inducible gene 1 (显示 RARRES3 蛋白) (RIG-I (显示 DDX58 蛋白)) modulated the interaction of activated proto-oncogene c-Src (Src) and STAT3 (显示 STAT3 蛋白) by competitive binding to STAT3 (显示 STAT3 蛋白).
Cbl, Cbl-b, and Cbl-c have a role in protecting mammary epithelial cellsfrom proteotoxic stress-induced cell death by promoting turnover of active c-Src
unlike c-fos-/- mice, c-src-/- mice demonstrated activated, mature osteoblasts, and parallel layers of cement lines in the superficial bone matrix, indicating the new bones were piled up to older bone.
TM, especially TME45, maintains vascular integrity, at least in part, via Src signaling.
We conclude that pp60(Src) can directly inhibit DDAH (显示 DDAH2 蛋白) II and this is involved in the increased ADMA levels that enhance eNOS (显示 NOS3 蛋白) uncoupling during the development of acute lung injury (ALI).
Ambra1 (显示 AMBRA1 蛋白) binds to both FAK (显示 PTK2 蛋白) and Src in cancer cells. When FAK (显示 PTK2 蛋白) is present, Ambra1 (显示 AMBRA1 蛋白) is recruited to focal adhesions, promoting FAK (显示 PTK2 蛋白)-regulated cancer cell direction-sensing and invasion. However, when Ambra1 (显示 AMBRA1 蛋白) cannot bind to FAK (显示 PTK2 蛋白), abnormally high levels of phospho-Src and phospho-FAK (显示 PTK2 蛋白) accumulate at focal adhesions, positively regulating adhesion and invasive migration.
Thus we propose that Cx43 (显示 GJA1 蛋白) might enhance the activation of Nrf2 (显示 NFE2L2 蛋白)/ARE pathway by means of inhibiting c-Src activity to hinder the nuclear export of Nrf2 (显示 NFE2L2 蛋白), and then reduce expression of FN, ICAM-1 (显示 ICAM1 蛋白) and TGF-b1, ultimately attenuating renal fibrosis in diabetes.
Osteoprotegerin (显示 TNFRSF11B 蛋白) may induce podosome reassembly and peripheral adhesive structure detachment by modulating phosphorylation of Pyk2 (显示 PTK2B 蛋白) and Src and their intracellular distribution in osteoclasts.
Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.
Data show that the actin-Capping Protein (显示 TMOD4 蛋白) (CP) alphabeta heterodimer, which regulates actin (显示 ACTB 蛋白) filament (F-actin (显示 ACTB 蛋白)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (显示 MAPK8 蛋白) activation.
Dumbfounded/Neph1 (显示 NEPH1 蛋白), a key diaphragm constituent, is a target of the Src kinase (显示 CSK 蛋白) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (显示 NEPH1 蛋白) tyrosine phosphorylation.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
E4orf4 has a role in inducing PP2A (显示 PPP2R2B 蛋白)- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster
Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.
Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (显示 ACTB 蛋白) formation and Jun kinase (显示 MAPK9 蛋白) activation in plasmatocytes.
Results suggest that Src promotes EGF (显示 EGF 蛋白)-stimulated EMT (显示 ITK 蛋白) and migration by upregulation of ZEB1 and ZEB2 (显示 ZEB2 蛋白) through AKT (显示 AKT1 蛋白) signaling pathway in gastric cancer cells.
Combined targeting of AKT (显示 AKT1 蛋白) and SRC resulted in a synergistic efficacy against human pancreatic cancer growth and metastasis.
important roles for c-Src tyrosine kinase (显示 CSK 蛋白) in phosphorylation and activation of SLC11A1 (显示 SLC11A1 蛋白) in macrophages
Our data suggest that targeting Src signaling may be an effective approach to the treatment of ALK-non-small cell lung cancer (NSCLC) with acquired resistance to ALK inhibitors.
Src kinase (显示 CSK 蛋白) in chemo-naive human primary osteosarcoma cells is differentially activated.
This study demonstrates that simultaneous inhibition of c-Met and Src signaling in MD-MSCs triggers apoptosis and reveals vulnerable pathways that could be exploited to develop NF2 (显示 NF2 蛋白) therapies.
Syntenin (显示 SDCBP 蛋白) mediates SRC function in exosomal cell-to-cell communication.
Endothelial cell-derived matrix promotes the metabolic functional maturation of hepatocyte via integrin-Src signaling.
The expression of Src under the influence of nilotinib, dasatinib, erlotinib, gefitinib and afatinib was studied in HPV-positive head and neck squamous cell carcinomas. Src expression was significantly increased by all tested tyrosine kinase (显示 TXK 蛋白) inhibitors.
Multivariate Cox (显示 COX8A 蛋白) regression analysis suggested that PTPRA (显示 PTPRA 蛋白) expression was an independent prognostic factor in SCC (显示 CYP11A1 蛋白) patients. In the cellular models, PTPRA (显示 PTPRA 蛋白) promotes SCC (显示 CYP11A1 蛋白) cell proliferation through modulating Src activation as well as cell cycle progression. In conclusion, higher PTPRA (显示 PTPRA 蛋白) level was associated with worse prognosis of SCC (显示 CYP11A1 蛋白) patients and PTPRA (显示 PTPRA 蛋白) could promote the cell cycle progression
RhoA (显示 RHOA 蛋白) and membrane fluidity mediates the spatially polarized Src/FAK (显示 PTK2 蛋白) activation in response to shear stress.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
src has a role in activation of 5'-AMP (显示 TMPRSS5 蛋白)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
These results suggest that TGF-beta1 (显示 TGFB1 蛋白)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (显示 PTK2 蛋白)/Src-dependent and -independent pathways.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (显示 ATP1A1 蛋白) activity and SFK signaling.
Src kinase (显示 CSK 蛋白) mediates hypoxia-induced caspase-1 (显示 CASP1 蛋白) activation in the cerebral cortex of newborn piglets
Expression of mutant alpha1 Na/K-ATPase (显示 ATP1A1 蛋白) defective in conformational transition attenuates Src-mediated signal transduction
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
proto-oncogene tyrosine-protein kinase SRC
, proto-oncogene tyrosine-protein kinase src
, neuronal proto-oncogene tyrosine-protein kinase Src
, proto-oncogene c-Src
, Src proto oncogene sequence
, mRNA-like ncRNA in embryogenesis 5
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1
, Rous sarcoma oncogene
, tyrosine protein kinase c-src
, tyrosine protein kinase pp60-c-src
, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, src oncogene
, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, non-tyrosine protein kinase