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抗Human SOCS3 抗体:
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抗Rat (Rattus) SOCS3 抗体:
Human Polyclonal SOCS3 Primary Antibody for ELISA, IF (p) - ABIN670416
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
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Human Monoclonal SOCS3 Primary Antibody for ELISA, WB - ABIN2476543
Rychlíková, Démant: Influence of non-H-2 genotype on the response to H-2-linked mixed lymphocyte reaction stimulating (MLR-S) genes. in Folia biologica 1975
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Human Polyclonal SOCS3 Primary Antibody for IHC, IHC (p) - ABIN4355049
Harris, Apolzan: Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. in Physiology & behavior 2014
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Human Monoclonal SOCS3 Primary Antibody for WB - ABIN153119
Xiang, Dong, Liu, Wang, Shi, Wei, Hu, Gong: Inhibitory effects of suppressor of cytokine signaling 3 on inflammatory cytokine expression and migration and proliferation of IL-6/IFN-?-induced vascular smooth muscle cells. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2013
Human Polyclonal SOCS3 Primary Antibody for ELISA, WB - ABIN262251
Roberts, Robb, Rakar, Hartley, Cluse, Nicola, Metcalf, Hilton, Alexander: Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. in Proceedings of the National Academy of Sciences of the United States of America 2001
Human Monoclonal SOCS3 Primary Antibody for IF, IHC (p) - ABIN522456
Pierconti, Martini, Pinto, Cenci, Capodimonti, Calarco, Bassi, Larocca: Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior. in The Prostate 2011
Human Polyclonal SOCS3 Primary Antibody for WB - ABIN1883384
Kim, Kim, Liu, Cao, Chen: Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. in The Journal of biological chemistry 2008
Human Polyclonal SOCS3 Primary Antibody for IHC, ELISA - ABIN1585262
van de Loo, Veenbergen, van den Brand, Bennink, Blaney-Davidson, Arntz, van Beuningen, van der Kraan, van den Berg: Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function. in Arthritis and rheumatism 2012
Human Monoclonal SOCS3 Primary Antibody for WB - ABIN94467
Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion. in Endocrine-related cancer 2007
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we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq (显示 SFPQ 抗体) and Socs3a
stat3 (显示 STAT3 抗体)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (显示 TRPM7 抗体) regulates exocrine pancreatic development via the Mg(2 (显示 MCOLN1 抗体)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (显示 MAPK1 抗体) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (显示 SOCS1 抗体) and SOCS3 proteins.
SOCS3 was targeted by miR30a- 5p in allergic rhinitis
Cellular viability was significantly decreased, whereas IL6 (显示 IL6 抗体) and TNFalpha (显示 TNF 抗体) levels were significantly increased, following High Glucose stimulation of A549 cells. In addition, the protein levels of SOCS3, pJAK2 and pSTAT3 were significantly increased in High Glucosetreated cells.
this study shows that Nrf2 (显示 GABPA 抗体) activation induces lipocyte phenotype in hepatic stellate cells via enhancing SOCS3-dependent feedback inhibition on JAK2 (显示 JAK2 抗体)/STAT3 (显示 STAT3 抗体) cascade
SOCS-1 (显示 SOCS1 抗体), SOCS-2 (显示 SOCS2 抗体), and SOCS-3 proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer
Our study showed that the expressions of HER2 (显示 ERBB2 抗体), STAT3 (显示 STAT3 抗体), and SOCS3 are associated with the progression of ovarian cancer (OC), and higher expressions of HER2 (显示 ERBB2 抗体) and STAT3 (显示 STAT3 抗体) and lower expression of SOCS3 predict poor prognosis of OC.
Authors found that SOCS3 and SOCS1 (显示 SOCS1 抗体) expression was reduced in vivo, in tumor lesions of BCC and SCC (显示 CYP11A1 抗体), as compared to other skin inflammatory conditions such as psoriasis, despite the high number of IL-22 (显示 IL22 抗体)-secreting TILs.
the presence of SOCS3 methylation is a marker to predict treatment response and prognosis in HCC (显示 FAM126A 抗体) patients receiving TACE (显示 ADAM17 抗体) therapy.
anti-miR (显示 MLXIP 抗体)-203 suppresses breast cancer cell proliferation in vitro by targeting SOCS3 [review]
miR (显示 MLXIP 抗体)-2909 could play a vital role in prostate carcinogenesis through modulation of ISGylation system and TGFbeta (显示 TGFB1 抗体) signalling via STAT1 (显示 STAT1 抗体)/SOCS3.
Data show that miR (显示 MLXIP 抗体)-222-3p targeted SOCS3 genes and down-regulation of SOCS3 correlated with an increased expression of STAT3 (显示 STAT3 抗体) activation.
SOCS3 is an important negative regulator of insulin (显示 INS 抗体) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (显示 IL10 抗体) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
SOCS3 was upregulated in lung CD4 (显示 CD4 抗体)+ T cells in a mouse model of chronic PA lung infection and exogenous SOCS3 suppressed Th17-mediated neutrophil recruitment in vitro.
findings show SOCS3 does not appear to mediate the early inflammatory or leucine-induced changes in protein synthesis in skeletal muscle
The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 (显示 IL6 抗体) and expression of sex hormones.
High SOCS3 expression is associated with glioma.
Mechanistic analysis indicated that E47 (显示 TCF3 抗体) activated expression of the transcription factor Spi-B (显示 SPIB 抗体) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (显示 FOXP3 抗体) expression. These findings demonstrate that the balance of Id3 (显示 ID3 抗体) and E47 (显示 TCF3 抗体) controls the maintenance of Foxp3 (显示 FOXP3 抗体) expression in Treg cells and, thus, contributes to Treg cell plasticity.
Our results show, for the first time, that SOCS-3 regulates leptin (显示 LEP 抗体)-induced responses in cartilage
Loss of suppressor of cytokine (SOCS3) expression in mature muscle fibers increased the inflammatory response to myotoxic injury but did not impair muscle regeneration in either adult or old mice. Therefore, reduced SOCS3 expression in muscle fibers is unlikely to underlie impaired muscle regeneration.
Findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects.
Findings indicate that inactivation of the Rb family proteins (Rb, p107 (显示 RBL1 抗体), and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO (显示 MRPS12 抗体)) HSCs.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3