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抗Mouse (Murine) Serotonin Receptor 2B 抗体:
抗Human Serotonin Receptor 2B 抗体:
抗Rat (Rattus) Serotonin Receptor 2B 抗体:
Human Polyclonal Serotonin Receptor 2B Primary Antibody for IHC, IHC (p) - ABIN4276881
De Sousa E Melo, Wang, Jansen, Fessler, Trinh, de Rooij, de Jong, de Boer, van Leersum, Bijlsma, Rodermond, van der Heijden, van Noesel, Tuynman, Dekker, Markowetz, Medema, Vermeulen: Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. in Nature medicine 2013
5-HT(2) receptors are coupled to phospholipase C (显示 PLC 抗体) in bovine ciliary epithelium.
Our results indicate that prolonged Htr2b activation in murine beta-cells decreases glucose-stimulated insulin secretion and mitochondrial activity by mechanisms likely dependent on enhanced PGC1a/PPARygexpression.
heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
Activation of 5-HT2B receptors stimulates GSIS in beta cells by triggering downstream changes in cellular Ca(2 (显示 CA2 抗体)+) flux that enhance mitochondrial metabolism.
Heritable pulmonary arterial hypertension (PAH) results from increased SRC activation, cellular contraction, and vascular resistance, but antagonism of HTR2B prevents SRC phosphorylation and development of PAH.
Results support that the abnormal organization of retinal projections in Htr2B-/- animals is due to the lack of 5-HT (显示 DDC 抗体) activation of 5-HT2B receptors in postnatal microglial cells
5-HT2B stimulation has no effectin neurite outgrowth.
the serotonin transporter (显示 SLC6A4 抗体) has a role in regulating clearance of apoptotic cells through neuroendocrine signaling
Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR (显示 PPARA 抗体)-ss/delta in osteoblasts.
the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT.
Augmented contractile properties of arteries in a model of type 2 diabetes mellitus are not due to changes in 5HT (显示 DDC 抗体)(2A)/5HT (显示 DDC 抗体)(2B) receptors.
The 3.0-A resolution structure of a complex between the human 5-hydroxytryptamine 2B (5-HT2B) receptor and an antibody Fab (显示 FANCB 抗体) fragment bound to the extracellular side of the receptor reveals the mechanism of selectivity in extracellular recognition of the receptor by monoclonal antibodies.
These findings suggest that 5-HT (显示 DDC 抗体) promotes CCN2 (显示 CTGF 抗体) production through the 5-HT2AR in growth plates, and that it represses CCN2 (显示 CTGF 抗体) production through the 5-HT2BR in articular cartilage for harmonized development of long bones
MFSD2B, CCL20 (显示 CCL20 抗体) and STAT1 (显示 STAT1 抗体), or STARD7 (显示 STARD7 抗体) and ZNF512 (显示 ZNF512 抗体) genes may be risk or protect factors in prognosis of ADC (显示 ADC 抗体); HTR2B, DPP4 (显示 DPP4 抗体), and TGFBRAP1 (显示 TGFBRAP1 抗体) genes may be risk factors in prognosis of SQC (显示 QPCT 抗体).
The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin (显示 INS 抗体) sensitivity among HTR2B Q20* carriers with low testosterone levels.
Study describes the crystal structure of Lysergic acid diethylamide (LSD (显示 DNASE1L3 抗体)) in complex with the human serotonin receptor (显示 HTR1B 抗体) 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD (显示 DNASE1L3 抗体), providing a structural explanation for the conformational selectivity of LSD's key diethylamide moiety.
The 5-HT2B receptor may contribute to the regulation of human glucagon (显示 GCG 抗体) and glucose homeostasis and the interplay between glucagon (显示 GCG 抗体) and insulin (显示 INS 抗体) secretion.
Authors hypothesize that HTR2B expression in the infarcted territory may render degenerating neurons susceptible to attack by activated microglia and thus aggravate the consequences of stroke.
the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in amyotrophic lateral sclerosis
distribution of serotonin 2B receptor is species different in the pig small intestine and the intensity of serotonin 2B receptor becomes stronger as the small intestine matures
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
5-hydroxytryptamine (serotonin) receptor 2B
, 5-hydroxytryptamin receptor
, 5-hydroxytryptamine receptor 2B
, 5HT2B receptor
, serotonin receptor 2B
, 5-hydroxytryptamine receptor 2B-like
, NP75 protein
, 5-HT2B serotonin receptor
, 5-HT 2B receptor
, 5-hydroxytryptamine 2B receptor
, 5-hydroxytryptamine receptor 2B variant b
, stomach fundus serotonin receptor
, serotonin 2B receptor