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抗Mouse (Murine) PIAS1 抗体:
抗Human PIAS1 抗体:
抗Rat (Rattus) PIAS1 抗体:
Human Polyclonal PIAS1 Primary Antibody for IHC (p), WB - ABIN388054
Miyauchi, Yogosawa, Honda, Nishida, Yasuda: Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. in The Journal of biological chemistry 2002
Show all 7 Pubmed References
these results indicate that PIAS1 is a positive regulator of MYC (显示 MYC 抗体).
PIAS1 overexpression exacerbated mutant Huntingtin-associated (显示 KALRN 抗体) phenotypes and aberrant protein accumulation
Pias1 expression in primary myoblasts enhances the induction of cardiac muscle genes MyoD (显示 MYOD1 抗体), Myogenin (显示 MYOG 抗体) and Myomaker. Endothelial cell specific inactivation of Pias1 in vivo impairs yolk sac (显示 ADCY10 抗体) erythrogenesis, angiogenesis and recapitulates loss of myocardium muscle mass. Pias1 is an essential gene for YS erythropoiesis and vasculogenesis in vivo.
Data suggest overexpression of Pias1 in white adipose tissue (WAT) of obesity/prediabetes improves insulin (显示 INS 抗体) resistance; knockdown of Pias1 in normal WAT leads to insulin (显示 INS 抗体) resistance; Pias1 expression in WAT is down-regulated by c-Jun N-terminal kinase.
Between the E3 SUMO ligase PIAS1 and STAT-3 (显示 STAT3 抗体).
Knockdown of PIAS1 in astrocytes impairs the accumulation of nuclear STI1 (显示 STIP1 抗体) in response to irradiation. Moreover, a PIAS1 mutant lacking the STI1 (显示 STIP1 抗体) binding site is unable to increase STI1 (显示 STIP1 抗体) nuclear retention.
A novel role of PIAS1 in maintaining the quiescence of dormant hematopoietic stem cells and in the epigenetic repression of the myeloerythroid program.
The present study showed that PIAS1 functions as a SUMO E3 ligase of C/EBPbeta (显示 CEBPB 抗体) to regulate adipogenesis.
Piasy (显示 PIAS4 抗体) represses the synergistic activation of PITX2 (显示 PITX2 抗体) with interacting co-factors and Piasy (显示 PIAS4 抗体) represses Pias1 activation of PITX2 (显示 PITX2 抗体) transcriptional activity.
MAPK-activated protein kinase-2 limits endothelial inflammation via the PIAS1 S522 phosphorylation-mediated increase in PIAS1 transrepression and SUMO ligase activity.
PIAS1 is a prognostic biomarker in breast cancer
PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer
HBs protein-induced hPIAS1 transcription requires TAL1 (显示 TAL1 抗体), E47 (显示 TCF3 抗体), MYOG (显示 MYOG 抗体), NFI (显示 NFIC 抗体), and MAPK (显示 MAPK1 抗体) signal pathways
identified the SUMO ligase PIAS1 as a constituent PML (显示 PML 抗体)-NB antiviral protein. This finding distinguishes a SUMO ligase that may mediate signaling events important in promyelocytic leukemia (显示 PML 抗体) nuclear body mediated intrinsic immunity.
PIAS1 enhances p300 (显示 EP300 抗体) recruitment to c-Myb (显示 MYB 抗体)-bound sites through interaction with both proteins. In addition, the E3 activity of PIAS1 enhances further its coactivation
Results show that apocrine breast cancer and prostate cancer cells share a core AR cistrome and target gene signature linked to cancer cell growth, and PIAS1 plays a similar coregulatory role for AR in both cancer cell types.
c-Myc (显示 MYC 抗体) is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 (显示 SENP7 抗体) and RNF4 (显示 RNF4 抗体)
Data demonstrate that PIAS1 interacts with TRF2 (显示 TERF2 抗体) and mediates its sumoylation serving as a molecular switch that controls the level of TRF2 (显示 TERF2 抗体) at telomeres.
This gene encodes a member of the mammalian PIAS
protein inhibitor of activated STAT, 1
, DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
, DEAD/H box-binding protein 1
, E3 SUMO-protein ligase PIAS1
, protein inhibitor of activated STAT protein 1
, AR interacting protein
, RNA helicase II-binding protein
, gu-binding protein
, protein inhibitor of activated STAT-1
, zinc finger, MIZ-type containing 3
, SUMO E3 ligase