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Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803917
Moon, Chamberland, Diakopoulos, Fiorenza, Ziemke, Schneider, Mantzoros: Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans. in Diabetes Care 2011
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Sheep (Ovine) Leptin Protein expressed in - ABIN623942
Szczesna, Zieba, Klocek-Gorka, Misztal, Stepien: Seasonal effects of central leptin infusion and prolactin treatment on pituitary SOCS-3 gene expression in ewes. in The Journal of endocrinology 2010
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Rat (Rattus) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803914
Castellano, Navarro, Fernández-Fernández, Roa, Vigo, Pineda, Dieguez, Aguilar, Pinilla, Tena-Sempere: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. in Diabetes 2006
Results demonstrated that overexpressed cardiac leptin, coinciding with myocardial ischemia and reperfusion, potentiates myocardial remodeling. This occurs via cardiomyocyte hypertrophy and fibrosis, and leads to augmented post-myocardial infraction heart failure.
We demonstrated here that the in vivo administration of leptin significantly induces neutrophil recruitment to the peritoneal cavity. We propose here that this is an indirect effect of leptin, which requires peritoneal resident cell activation with the production of TNFalpha and CXCL1, mostly by resident monocytes/macrophages.
This study uncovers a developmental function of leptin that may be linked to the pathogenesis of neurological disorders and helps understanding how maternal environment can adversely impact offspring brain development.
Osteopontin overexpression in non-alcoholic steatohepatitis enhances leptin-mediated fibrogenesis via PI3K/Akt.
The study shows a novel role of leptin-induced P2X7r in modulating Glut4 induction and translocation in hepatic stellate cells, that are key to nonalcoholic steatohepatitis progression.
Leptin modulates adventitial pericyte functions by autocrine and paracrine signaling.
In C57bl/6 model, glycaemic index of maternal dietary carbohydrates differentially alters Fto and Lep expression in offspring.
A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models
Catalase overexpression modulates metabolic parameters in a new 'stress-less' leptin-deficient mouse model.
Since upregulation of ANGPTL6 is induced on metabolic stress, we investigated the hepatic expression of ANGPTL6 by leptin, a representative adipokine of obesity. Mice on a high-fat diet showed increased serum leptin levels and hepatic Angptl6 expression.
This study shows that prolonged exposure to high-fat diets in adulthood is associated with a gradually increasing DNA methylation level at the Leptin and Pparg2 promoters in a depot-specific manner.
the study reports a novel mechanistic pathway of leptin-mediated renal inflammation that is dependent on NOX-2-miR21 axis in ectopic manifestations underlying non-alcoholic fatty liver disease-induced co-morbidities
These results demonstrated a novel molecular mechanism by which leptin sustained oligodendrocyte precursor cell proliferation and remyelination in a pathological central nervous system.
These data demonstrate that FAAH activity is required for leptin's hypophagic effects
These data uncouple the mechanisms conferring qualitative and quantitative expression of the leptin gene and further suggest that factor(s) that bind to LepRE1 quantitatively control leptin expression and might be components of a lipid-sensing system in adipocytes.
These results indicate that leptin plays a role in nociception induced by acute inflammation
results suggest that STAT transcriptional activity is downregulated by high levels of leptin, leading to reduced cAMP-dependent steroidogenic genes (Star and Cyp11a1) expressions in MA-10 Leydig cells.
Data suggest that lnc-leptin is among the most prominent lncRNAs expressed in adipocytes; lnc-leptin expression from an enhancer region upstream of leptin is sensitive to insulin and correlates to leptin expression across diverse pathophysiological conditions; induction of lnc-leptin is essential for adipogenesis; its presence is required for maintenance of leptin expression in adipocytes. (lnc = long non-coding RNA)
Data (including data from studies using mutant, transgenic, and knockout mice) suggest that gene targets of leptin/leptin-receptor (Lep/Lepr) signaling in hypothalamic neurons regulate energy metabolism; Lep/Lepr signaling appears to up-regulate expression of Atf3 (activating transcription factor-3) in hypothalamic neurons.
Study shows that compared to the other mouse lines, db/db mice with dysfunctional leptin receptors had a significantly longer tail flick latency after saline and buprenorphine. The results provide novel support for the interpretation that acute thermal nociception is associated with altered leptin signaling.
mechanisms for leptin and ghrelin regulation of tolerogenic functions of dendritic cells in pregnancy
The higher levels of leptin in the overweight and obese pregnant women seem to reflect the leptin resistance.
Serum leptin levels did not differ significantly in fertile and infertile groups, and no association was found with infertility.
Maternal blood leptin concentration is not significantly different between small for gestational age neonates and healthy controls.
Leptin polymorphism may increase asthma risk via influence on its serum level
positive relationships between leptin levels and bone mineral parameters are weak, or not always observed, due to statistical problems (i.e., multicollinearity) and other factors derived from adipose tissue.
subcutaneous adipose tissue and liver fat content were identified as predominant sites associated with leptin and vaspin levels, respectively
Leptin-induced cardiomyocyte hypertrophy is associated with enhanced mitochondrial fission via a calcineurin-mediated pathway
Leptin gene variants may exhibit sex-specific associations with colorectal cancer risk.
Leptin:Adiponectin ratio may be a good surrogate biomarker of early obesity-related metabolic disturbances.
Leptin and SLeptinR[ serum Leptin receptor] are independently and inversely associated with GDM [of gestational diabetes mellitus]. Lower levels of these peptides may play an important role in the pathophysiology of GDM and pre-diabetic state in post-puerperium.
Minor allele frequencies of rs10487506, rs7799039, rs2167270, rs12706832, and rs10954173 LEP variants were not significantly different between polycystic ovary syndrome cases and control women among Bahraini and Tunisians, However, five-locus haplotype analysis identified GGGGG and GAGGG haplotypes to be positively, and haplotype AAGGG to be negatively, associated with polycystic ovary syndrome
Investigated aromatase regulation by leptin involving the p53-HIF1alpha/PKM2-aromatase axis and studied in situ, the association of BMI and the breast ASC-specific immunoreactivity of members of the p53-HIF1alpha/PKM2-aromatase axis.
Data suggest that leptin- to- adiponectin ratio might be a powerful diagnostic marker of postmenopausal women with metabolic syndrome.
Leptin can modulate the oxidative status of mammary epithelial cells differently according to their neoplastic state. These novel results shed light on oxidative status changes in mammary cells in the presence of leptin
The present study indicates a favorable relationship between leptin and sleep quality in obese type 2 diabetes patients
High circulating leptin levels predict the development of insulin resistance in adult men.
Review of leptin's role in breast and gynecologic cancer, focusing on its role in cancer stem cells. [Review Article]
results provide new information about associations between leptin, sex-specific weight and appetite changes and problematic eating behaviours, which may be risk factors for cardiovascular and metabolic diseases in Manic Depressive Disorder, particularly in females.
mutation-induced leptin deficiency may arise from several distinct mechanisms including (i) blockade of leptin receptor interface II, (ii) decreased affinity in the second step of leptin's interaction with its receptor, (iii) leptin destabilization, and (iv) unsuccessful threading through the covalent loop, leading to leptin misfolding/aggregation.
study has allowed a transcriptional characterization of LEP and LEPR isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.
A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance
Leptin and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.
The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses from lean and obese/leptin resistant swine.
Locally produced leptin plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs.
These results indicate that leptin and its receptors are expressed in porcine luteal cells and suggest that estradiol and progesterone affect leptin mRNA expression and leptin secretion during the mid-luteal phase of the estrous cycle.
results suggest the T alleles of both LEP g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake
Linkage disequilibrium analysis among MC4R, LEP and H-FABP revealed that these genes were independent.
role of transcription factor p53 and the metabolic hormone leptin, in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells
The expression levels of leptin in the ovary during mid- and late-luteal phase of the oestrous cycle as well as during days 14-16 and 30-32 of pregnancy is reported.
These results suggest that SNP G-2863A is a potential DNA marker for backfat thickness and has a regulatory role in leptin transcription.
Increases in epicardial perivascular adipose tissue leptin exacerbate coronary endothelial dysfunction in MetS via a PKC-beta-dependent pathway.
These results indicate that both leptin and OB-Rb are synthesized in the porcine hypothalamus and participate in control of reproduction during the oestrous cycle and early pregnancy.
Consistent with this, leptin enhanced GnRH-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.
The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.
A leptin SNP (LEPg.978) was significantly associated with a weight at one year.
The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.
Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways.
Leptin R25C genotype impacted most traits associated with fatness.
The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY) release.
It is an important regulator of metabolic efficiency, energy expenditure, food intake and body fat mass.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
Results indicated that leptin R25C genotype impacted most traits associated with fatness whereas feeding zilpaterol for 21 d affected weight gain positively but impacted other variables negatively.
There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.
The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
The use of leptin, leptin receptor, and DGAT1 polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.
The leptin and receptor gene markers would be useful for marker-assisted selection.
A significant positive relationship exists between the T allele frequency in the bovine leptin C/T SNP and animal backfat, with TT, CT and CC animals having estimates of 6.79 +/- 0.02, 6.49 +/- 0.01 and 6.28 +/- 0.01 mm, respectively.
The impact of different alleles of DGAT1 and leptin on milk production in Giorlando cattle is reported.
The effects of dietary energy on the metabolism of ghrelin, leptin and growth hormone secretagogue receptor in blood and tissues of steers are reported.
polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production
study suggests that increased CSF leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 after traumatic brain injury, leads to accelerated fracture healing
We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin.
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma and CD36 mRNA expression in hypercholesterolemic rabbits.
Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.
Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.
Plasma levels of leptin (as well as glucose, insulin, and growth hormone) are highly correlated with the duration of winter anovulatory phase.
GHRL, LEP, ADIP, INS and CORT concentrations were measured using radioimmunoassay
positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares
The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin in a set of four chair-restraint habituated intact adult male rhesus monkeys.
results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
, leptin (murine obesity homolog)
, leptin (obesity homolog, mouse)
, obese protein
, obese, mouse, homolog of