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抗Mouse (Murine) Leptin 抗体:
抗Human Leptin 抗体:
抗Rat (Rattus) Leptin 抗体:
Mouse (Murine) Polyclonal Leptin Primary Antibody for ELISA, WB - ABIN3043294
Cheng, Dai, Dai: Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cvarepsilon and is attenuated by an endothelin receptor antagonist CPU0213. in Reproductive toxicology (Elmsford, N.Y.) 2010
Show all 3 Pubmed References
Human Monoclonal Leptin Primary Antibody for ELISA, IF - ABIN1996123
Sun, Park, Gupta, Holland, Auerbach, Zhang, Goncalves Marangoni, Nicoloro, Czech, Varga, Ploug, An, Scherer: Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. in Nature communications 2014
Cow (Bovine) Polyclonal Leptin Primary Antibody for IHC, WB - ABIN2776943
Müller, Kowalewski, Reichler, Kollár, Balogh: Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs. in Reproduction in domestic animals = Zuchthygiene 2017
Human Polyclonal Leptin Primary Antibody for ELISA, WB - ABIN2475318
Paracchini, Pedotti, Taioli: Genetics of leptin and obesity: a HuGE review. in American journal of epidemiology 2005
Cow (Bovine) Polyclonal Leptin Primary Antibody for IF (p), IHC (p) - ABIN668243
Chu, Zhao, Feng, Zhang, Liu, Cheng, Li, Shen, Cao, Li, Min: MicroRNA-126 participates in lipid metabolism in mammary epithelial cells. in Molecular and cellular endocrinology 2017
Thus, Mc4r (显示 MC4R 抗体) in the PVH appears to be required for early-life programming of hypertension arising from either maternal obesity or neonatal hyperleptinemia. Early-life exposure of the PVH to maternal obesity through postnatal elevation of leptin may have long-term consequences for cardiovascular health.
t the cellular level, leptin promoted effector T-cell responses and facilitated the presentation of self-antigens to T cells, whereas it inhibited the activity of regulatory CD4 (显示 CD4 抗体) T cells. The understanding of the role of leptin in modulating autoimmune responses in SLE can open possibilities of leptin-targeted therapeutic intervention in the disease.
plasma adiponectin and leptin were also decreased in IL 10tm.These findings suggest that frailty observed in this mouse model of chronic inflammation may in part be driven by alterations in fat mass, hormone secretion and energy metabolism
in congenitally leptin deficient animals, leptin is not required for compensatory reduction in energy expenditure accompanying weight loss, but suggest that the hyperphagia of the weight-reduced state is leptin-dependent.
Our data provide evidence that the interplay of these two hormones could help improve the understanding of the pathogenesis of atherosclerosis and NAFLD (显示 TSC2 抗体).
Data suggest that Htr2c (显示 HTR2C 抗体) and leptin in hypothalamic nuclei may be involved in the effects of corticosterone on food intake/appetite regulation. (Htr2c (显示 HTR2C 抗体) = 5-hydroxytryptamine type 2C receptor)
Further experiments indicated that miR (显示 MLXIP 抗体)-122 inhibited leptin-induced liver fibrosis in leptin-deficient mouse model.
Endoplasmic reticulum stress-induced CHOP (显示 DDIT3 抗体) activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin and IGF1 (显示 IGF1 抗体).
neuronal Rap1 (显示 TERF2IP 抗体) critically regulates leptin sensitivity
Upregulation of leptin levels in both the vessel wall and the circulation after vessel injury promoted the migration of Sca-1 (显示 Ly6a 抗体)(+) progenitor cells via leptin receptor (显示 LEPR 抗体)-dependent signal transducer and activator of transcription 3 (显示 STAT3 抗体)- Rac1/Cdc42 (显示 CDC42 抗体)-ERK (显示 EPHB2 抗体) (extracellular signal-regulated kinase)-FAK (显示 PTK2 抗体) pathways, which enhanced neointimal formation.
These findings are consistent with higher levels of serum leptin being associated with asthma regardless of age, and low adiponectin levels being associated with asthma in adults only.
These findings suggest that specific MFN2 (显示 MFN2 抗体) mutations cause tissue-selective mitochondrial dysfunction with increased adipocyte proliferation and survival and confirm a novel form of excess adiposity with paradoxical suppression of leptin expression.
The G-allele of leptin gene polymorphism (G2548A) was associated with increased BP levels during pregnancy and the postpartum.
Study demonstrates that fasting induces changes in DNA methylation. This was shown in LEP and ADIPOQ promoters in subcutaneous adipose tissue among normal birth weight (NBW) but not low birth weight (LBW) subjects. The altered epigenetic flexibility in LBW subjects might contribute to their differential response to fasting, adipokine levels, and increased risk of metabolic disease.
We conclude that elevated plasma leptin levels are associated with impaired left ventricular diastolic function in patients with coronary artery disease independently of obesity and other confounding variables.
The results of our study suggest an association between adiponectin gene rs266729 as well as leptin gene rs2167270 polymorphisms and Gestational diabetes mellitus
This study shows that leptin is measurable in exhaled breath condensate (EBC) in children and that exhaled breath condensate-leptin levels are significantly higher in the obese subjects and in asthmatic ones compared with healthy subjects.
Leptin is the most important adipokine in anorexia nervosa (AN). Leptin and free leptin index are the only factors that are influenced not only by the fat content.
Women spent almost 60% of their time sitting throughout pregnancy. In cross-sectional analyses, an association of sedentary time at 24weeks was found with increased total cholesterol and HDL (显示 HSD11B1 抗体). More sedentary time was associated with lower IL-6 (显示 IL6 抗体) at 24weeks and with higher IL-10 (显示 IL10 抗体), TNF-alpha (显示 TNF 抗体) and leptin levels at 32weeks of pregnancy.
When stratified by menopausal status free leptin index and soluble leptin receptor (显示 LEPR 抗体) remained as risk factors irrespective of menopausal status while LEPR (显示 LEPR 抗体) gene K109R A/G polymorphism remained as a risk factor only in the postmenopausal group.
study has allowed a transcriptional characterization of LEP and LEPR (显示 LEPR 抗体) isoforms on a range of tissues. Their expression patterns seem to indicate that both molecules develop peripheral roles apart from their known hypothalamic signal transduction function
The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.
A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.
The presence of leptin and ObR (显示 LEPR 抗体)-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
Studied 3'UTR (显示 UTS2R 抗体) leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR (显示 LEPR 抗体) in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR (显示 LEPR 抗体) complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb (显示 LEPR 抗体) mRNA in porcine endometrium was mainly negative-regulated by leptin
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance
Leptin and leptin receptor (显示 LEPR 抗体) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.
Consistent with this, leptin enhanced GnRH (显示 GNRH1 抗体)-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2 (显示 CA2 抗体)+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.
The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.
A leptin SNP (LEPg.978) was significantly associated with a weight at one year.
The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.
Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (显示 NPY 抗体) and insulin (显示 INS 抗体) signaling pathways.
Leptin R25C genotype impacted most traits associated with fatness.
The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (显示 NPY 抗体)) release.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR (显示 LEPR 抗体)/T945M affected significantly calving interval (P<0.01) only
polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production
study suggests that increased CSF (显示 CSF2 抗体) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (显示 IGF1 抗体) after traumatic brain injury, leads to accelerated fracture healing
We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (显示 GHRL 抗体).
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (显示 PPARG 抗体) and CD36 (显示 CD36 抗体) mRNA expression in hypercholesterolemic rabbits.
Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.
Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.
Plasma levels of leptin (as well as glucose, insulin, and growth hormone) are highly correlated with the duration of winter anovulatory phase.
GHRL (显示 GHRL 抗体), LEP, ADIP (显示 SSX2IP 抗体), INS (显示 INS 抗体) and CORT (显示 CORT 抗体) concentrations were measured using radioimmunoassay
positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares
The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin, and resistin (显示 RETN 抗体) in a set of four chair-restraint habituated intact adult male rhesus monkeys.
results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
, leptin (murine obesity homolog)
, leptin (obesity homolog, mouse)
, obese protein
, obese, mouse, homolog of