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we show by molecular replacement that Arg-112 does not participate in binding of IL-11 to its receptors IL-11R and glycoprotein 130 (gp130). Recombinant IL-11 R112H expressed in E. coli displays a correct four-helix-bundle folding topology, and binds with similar affinity to IL-11R and the IL-11/IL-11R/gp130 complex.
SNP rs10940495 in the gp130 locus was associated with functional outcome at 6 months following spontaneous intracerebral hemorrhage.
Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.
gp130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancer.
GP130 signaling is required for tumor cell survival in diverse forms of ALK- anaplastic large cell lymphoma, even in the presence of JAK1 (显示 JAK1 蛋白)/STAT3 (显示 STAT3 蛋白) mutations.
Data show that tumor suppressor adenomatous polyposis coli (APC (显示 APC 蛋白)) loss results in up-regulation of IL-6 (显示 IL6 蛋白) signal transducer (IL-6ST/gp130), thereby activating YAP (显示 YAP1 蛋白) (YY1 (显示 YY1 蛋白)-associated) protein (YAP (显示 YAP1 蛋白)) which are simultaneously up-regulated in the majority of colorectal cancer (CRC (显示 CALR 蛋白)).
study focused on IL-6 (显示 IL6 蛋白) and activation of its receptors gp80 (显示 CLU 蛋白) and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet (显示 FBXL15 蛋白) Kit, Unifast, and Duralay on control of inflammation
an impaired oxidative stress response in hepatocytes with gp130 gain-of-function mutations, as detected in dysplastic intrahepatic nodules and hepatocellular adenomas, is one of the central oncogenic mechanisms in chronic liver inflammation.
The sgp130, IL-6 (显示 IL6 蛋白), and sIL (显示 PMEL 蛋白)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 (显示 IL6 蛋白) trans-signaling pathway to the pathophysiology of DR.
This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease.
Genetic ablation of APN (显示 ANPEP 蛋白) expression had no effect on infectability by porcine epidemic diarrhea virus, demonstrating that APN (显示 ANPEP 蛋白) is not essential for porcine epidemic diarrhea virus cell entry.
pAPN (显示 ANPEP 蛋白) is not a functional receptor for porcine epidemic diarrhea virus, but promotes the infection of PEDV through its protease activity.
The C-terminal domain of the S1 domain of porcine epidemic diarrhea virus is bound to swine pAPN (显示 ANPEP 蛋白).
Data indicate that fluorogenic substrates can be successfully used to identify aminopeptidase N (显示 ANPEP 蛋白) and to measure their activity in cell lysates.
SPC (显示 SFTPC 蛋白) subdomain of APN (显示 ANPEP 蛋白) plays a key role in cell entry of PEDV and its expression permits PEDV growth
Porcine epidemic diarrhea virus recognizes protein receptor aminopeptidase N (显示 ANPEP 蛋白) from pig and human and sugar coreceptor N-acetylneuraminic acid.
These data demonstrate that pAPN (显示 ANPEP 蛋白), the cellular receptor for porcine epidemic diarrhea virus, mediates polarized virus infection.
It was concluded that the difference in F4 binding to ANPEP (显示 ANPEP 蛋白) is due to modifications in its carbohydrate moieties.
The region aa 673-722 of the C subunit of porcine aminopeptidase N (显示 ANPEP 蛋白) is indicated to play a key role in swine transmissible gastroenteritis virus binding.
The binding ability of four truncated porcine aminopeptidase N (显示 ANPEP 蛋白) proteins to transmissible gastroenteritis virus (TGEV), a porcine coronavirus, was analyzed by ELISA and immunoblotting.
EBI3 can mediate IL-6 trans-signaling in a process that involves gp130
data suggest that the different sgp130 forms are released from cells into their immediate surroundings and appear to form cell-associated gradients to modulate their own susceptibility for IL-6 (显示 IL6 蛋白) trans-signaling.
Blocking IL-6 (显示 IL6 蛋白) trans-signaling in the CNS abrogates the ability of IL-6 (显示 IL6 蛋白) to suppress feeding. Furthermore, gp130 (显示 LRPPRC 蛋白) expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of gp130 (显示 LRPPRC 蛋白) in the PVH attenuates the beneficial central IL-6 (显示 IL6 蛋白) effects on metabolism
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Results suggest that the protective role of gp130 (显示 LRPPRC 蛋白)-dependent STAT3 (显示 STAT3 蛋白) activation in experimental colitis involves the expansion and activation of mucosal myeloid-derived suppressor cells.
IL-6/gp130 signalling in the osteoclast is not essential for normal bone resorption in vivo, but maintains both trabecular and periosteal bone formation in male mice by promoting osteoblast activity through the stimulation of osteoclast-derived coupling factors and osteotransmitters
gp130 (显示 LRPPRC 蛋白)-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin (显示 INS 蛋白) resistance.
differences exist in the expression of receptors utilized by the IL-6 (显示 IL6 蛋白)/gp130 (显示 LRPPRC 蛋白) family of cytokines in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to oncostatin M (显示 OSM 蛋白) by astrocytes versus microglia
Deregulation of gp130 (显示 LRPPRC 蛋白)/STAT3 (显示 STAT3 蛋白) signalling augments the acute phase reponse and macrophage infiltration during atherosclerosis without impacting on the development of aortic plaques.
The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
, IL-6 receptor subunit beta
, IL-6R subunit beta
, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
, interleukin receptor beta chain
, interleukin-6 receptor subunit beta
, membrane glycoprotein 130
, membrane glycoprotein gp130
, oncostatin-M receptor subunit alpha
, interleukin-6 signal transducer
, interleukin 6 signal transducer
, glycoprotein 130
, LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta
, interleukin 6 signal transducer (gp130, oncostatin M receptor)
, interleukin 6 signal transducer receptor