anti-人 IL21 Receptor 抗体 for Immunoprecipitation

Recommended IL21 Receptor Antibody

抗原
Interleukin 21 Receptor (IL21R) 抗体
  • IL21R
  • il-21ra.a
  • CD360
  • NILR
  • interleukin 21 receptor
  • interleukin 21 receptor, tandem duplicate 1
  • IL21R
  • il21r.1
  • Il21r
适用

92
49
34
2
2
宿主
小鼠
93
6
5
3
克隆类型
单克隆
标记
This IL21 Receptor antibody is conjugated to APC
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
应用范围
Immunoprecipitation (IP), ELISA, Western Blotting (WB)
61
40
29
13
10
9
2
2
2
1
1
选项

Available images

产品编号 ABIN2658204
产品在该地区无法提供。
Relevance Score ABIN Application Conjugate Host Isotype Epitope Clonality References Details
7 ABIN2935469 IF/ICC IHC IP WB Rabbit AA 23-185 Polyclonal 0
1 ABIN2658205 IP ELISA WB APC Mouse IgG1 kappa 17A12 10
1 ABIN6334607 IF/ICC IHC IP WB Mouse 0

General

抗原 Interleukin 21 Receptor (IL21R) 抗体
适用
(92), (49), (34), (2), (2)
宿主 小鼠
(93), (6), (5), (3)
克隆类型 (克隆位点)
单克隆   ( )
标记 This IL21 Receptor antibody is conjugated to APC
(4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
应用范围 Immunoprecipitation (IP), ELISA, Western Blotting (WB)
(61), (40), (29), (13), (10), (9), (2), (2), (2), (1), (1)
Pubmed 10个引用可参考
Supplier

IL21 Receptor抗体详情

IL21 Receptor目标详情 使用细节 贮存及处理 References for anti-IL21 Receptor antibody (ABIN2658204) 图像
纯化方法 The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
克隆位点 17A12
亚型 IgG1 kappa
Plasmids, Primers & others

IL21 Receptor目标详情

IL21 Receptor抗体详情 使用细节 贮存及处理 References for anti-IL21 Receptor antibody (ABIN2658204) 图像 回页首
抗原
别名 CD360 (IL21R Antibody 摘要)
背景 Human interleukin 21 receptor (IL-21R) is a single pass type I membrane protein and a member of the type I cytokine receptor family. Of the type I cytokine receptors, IL-21R exhibits greatest extracellular homology to the IL-2R beta subunit (i.e., it contains one copy of the WSXWS-containing cytokine-binding domain). Intracellular domains of IL-21R include the Box 1 and Box 2 elements, which are similar to the IL-9R intracellular region. Upon binding IL-21, IL-21R forms a heterodimer with the common gamma subunit (CD132) and induces Jak/Stat signaling. IL-21R is expressed on B cells and at various levels on NK and T cells. IL-21 is a potent immunomodulatory cytokine mainly produced by NKT and CD4 T-cells (particularly the inflammatory Th17 subset) and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells and direct inhibitory effects on the antigen-presenting function of dendritic cells, and can be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
途径 JAK/STAT Signaling

使用细节

IL21 Receptor抗体详情 IL21 Receptor目标详情 贮存及处理 References for anti-IL21 Receptor antibody (ABIN2658204) 图像 回页首
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用

贮存及处理

IL21 Receptor抗体详情 IL21 Receptor目标详情 使用细节 References for anti-IL21 Receptor antibody (ABIN2658204) 图像 回页首
缓冲液 Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Protect from prolonged exposure to light. Do not freeze.
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL21 Receptor antibody (ABIN2658204)

IL21 Receptor抗体详情 IL21 Receptor目标详情 使用细节 贮存及处理 图像 回页首
背景

Bannantine, Stabel, Lamont, Briggs, Sreevatsan: "Monoclonal Antibodies Bind A SNP-Sensitive Epitope that is Present Uniquely in Mycobacterium avium Subspecies Paratuberculosis." in: Frontiers in microbiology, Vol. 2, pp. 163, 2011

Spolski, Leonard: "Interleukin-21: basic biology and implications for cancer and autoimmunity." in: Annual review of immunology, Vol. 26, pp. 57-79, 2008

Davis, Skak, Smyth, Kristjansen, Miller, Sivakumar: "Interleukin-21 signaling: functions in cancer and autoimmunity." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 23, pp. 6926-32, 2007

Nurieva, Yang, Martinez, Zhang, Panopoulos, Ma, Schluns, Tian, Watowich, Jetten, Dong: "Essential autocrine regulation by IL-21 in the generation of inflammatory T cells." in: Nature, Vol. 448, Issue 7152, pp. 480-3, 2007

de Totero, Meazza, Zupo, Cutrona, Matis, Colombo, Balleari, Pierri, Fabbi, Capaia, Azzarone, Gobbi, Ferrarini, Ferrini: "Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells." in: Blood, Vol. 107, Issue 9, pp. 3708-15, 2006

Parrish-Novak, Foster, Holly, Clegg: "Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses." in: Journal of leukocyte biology, Vol. 72, Issue 5, pp. 856-63, 2002

Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001

Dumoutier, Van Roost, Colau, Renauld: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000

Ozaki, Kikly, Michalovich, Young, Leonard: "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 21, pp. 11439-44, 2000

Parrish-Novak, Dillon, Nelson, Hammond, Sprecher, Gross, Johnston, Madden, Xu, West, Schrader, Burkhead, Heipel, Brandt, Kuijper, Kramer, Conklin, Presnell, Berry, Shiota, Bort, Hambly, Mudri, Clegg et al.: "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. ..." in: Nature, Vol. 408, Issue 6808, pp. 57-63, 2000

图像

IL21 Receptor抗体详情 IL21 Receptor目标详情 使用细节 贮存及处理 References for anti-IL21 Receptor antibody (ABIN2658204) 回页首
厂商提供的图像
Flow Cytometry (FACS) image for anti-Interleukin 21 Receptor (IL21R) antibody (APC) (ABIN2658204) anti-Interleukin 21 Receptor (IL21R) antibody (APC)
Flow Cytometry (FACS) image for anti-Interleukin 21 Receptor (IL21R) antibody (APC) (ABIN2658204) anti-Interleukin 21 Receptor (IL21R) antibody (APC) (Image 2)