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Human IL15 Protein expressed in Escherichia coli (E. coli) - ABIN988042
Suzuki, McCall, Choi, Sicklick, Huang, Qi, Zdanowicz, Camp, Li, Diehl: Interleukin-15 increases hepatic regenerative activity. in Journal of hepatology 2006
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T cells in chimpanzees infected with human immunodeficiency virus express surface interleukin-15.
CD3 (显示 CD3 蛋白)(-) CD8 (显示 CD8A 蛋白)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma (显示 IFNG 蛋白), and that IL-15 elicits IFN-gamma (显示 IFNG 蛋白) production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15, CD8 (显示 CD8A 蛋白) antigen, IFN-gamma (显示 IFNG 蛋白)]
These data demonstrate that mice with an endogenous IL-15 deficiency are susceptible to the development of severe, enhanced Th2-mediated allergic airway disease, which can be regulated by CD8 (显示 CD8A 蛋白)(+) T cells.
IL-15 induces the activation and survival of effector immune cells that are necessary for its antitumoral activity; but, long-term exposure to IL-15 is associated with the development of important side effects mainly mediated by IFN-gamma (显示 IFNG 蛋白)-producing T-cells
findings indicated that IL-15 plays an important role in preventing leukemia development.
NK cells activated by IL-4 (显示 IL4 蛋白) in cooperation with IL-15 exhibit distinctive characteristics with enhanced immunologic cytotoxicity.
Genetic ablation of the IL2Rbeta chain on CD8 (显示 CD8A 蛋白)(+) T cells restrains inhibitory receptor induction, in particular 2B4 (显示 CD244 蛋白) and Tim-3 (显示 HAVCR2 蛋白); precludes terminal differentiation of highly defective PD-1 (显示 PDCD1 蛋白)(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7 (显示 IL7 蛋白)-dependent signals. Together, we ascribe a previously unexpected role to IL-2 (显示 IL2 蛋白) and IL-15 as instigators of CD8 (显示 CD8A 蛋白)(+) T-cell exhaustion during chronic viral infe...
aerobic interval training enhanced the anti-inflammatory indices IL-10 (显示 IL10 蛋白)/TNF-alpha (显示 TNF 蛋白) ratio and IL-15 expression in skeletal muscle in tumor-bearing mice.
this study reveals the function of IL-15 in astrocyte survival via Akt (显示 AKT1 蛋白) phosphorylation in response to OGD (显示 FGFR1 蛋白)-induced damage.
Our new compelling findings have established the critical roles of both IL-7 (显示 IL7 蛋白) and IL-15 in the maintenance of memory Th17 cells, and the previously undescribed therapeutic advantages of targeting IL-7 (显示 IL7 蛋白) and IL-15 further support a promising clinical translation in Th17 cell-mediated autoimmune and inflammatory disorders.
results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease
homeostasis of IL-15-dependent lymphocyte subsets is also regulated by trans-presentation of IL-15 by non-hematopoietic cells in the tissue environment.
IL-15 levels were found to be elevated in depressed patients with asthma.
this paper show that IL-15 boosts the function and migration of human terminally differentiated CD8 (显示 CD8A 蛋白)+ T cells by inducing a unique gene signature
inhibits the Ca(2 (显示 CA2 蛋白)+)-induced differentiation of keratinocytes, mainly via the attenuation of Ca(2 (显示 CA2 蛋白)+)-stimulated PI3K (显示 PIK3CA 蛋白)-AKT (显示 AKT1 蛋白) signalling
The 161533 TriKE induced superior NK cell cytotoxicity, degranulation, and cytokine production against CD33 (显示 CD33 蛋白)(+) HL-60 targets and increased NK survival and proliferation.
In this article, we review the functions, expression, and regulation of IL-15 for designing an improved IL-15-based therapy targeting the IL-15 signaling pathway.
n this study, authors compared the concentrations of IL-15 and IL-7 (显示 IL7 蛋白) in the plasma of MDS (显示 PAFAH1B1 蛋白) patients (n = 20) compared with that in the plasma of healthy controls (n = 20). Results indicated that exposure to high levels of IL-15 may be involved in the T cell phenotype conversion observed in MDS (显示 PAFAH1B1 蛋白).
the critical role played by IL-7 and IL-15 in T cell homeostasis and how these cytokines could be used to improve immune reconstitution after allogeneic SCT.
Downregulation of Hsc70 (显示 HSPA8 蛋白), Hsp70 (显示 HSP70 蛋白), and IL-15 expression at gene and/or protein levels might support the retention of fertilization products in cases of missed abortion and blighted ovum.
The presence of IL15 rs10833 AA genotype in HIV-/HCV-co-infected patients was associated with advanced liver fibrosis, inflammation-related biomarkers and increased rates of sustained virological response to pegIFN-alpha/RBV therapy.
High IL15 expression is associated with endometriosis.
Myokine IL-15 regulates the crosstalk of co-cultured porcine skeletal muscle satellite cells and preadipocytes.
results demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV)infection could induce IL-15 production in macrophages/dendritic cells; data further show that upregulation of IL-15 by PRRSV requires PKC (显示 FYN 蛋白) and NF-kappaB (显示 NFKB1 蛋白) pathways
IFN-gamma (显示 IFNG 蛋白) targets the adipocyte to induce IL-15 expression, thus indicating a possible role for the adipocyte in the regulation of T-cell function and muscle metabolism during the innate immune response
When induced by IFN-gamma (显示 IFNG 蛋白) or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2 (显示 BCL2 蛋白).
IL 15 generates a dramatic expansion of short-lived memory CD8 (显示 CD8A 蛋白) T cells and natural killer in immunocompetent macaques and has long-term effects on the balance of CD4 (显示 CD4 蛋白)(+) and CD8 (显示 CD8A 蛋白)(+) T cells.
These data suggest that therapeutic use of IL-15 in the setting of antiretroviral therapy might facilitate specific restoration of the CD4 (显示 CD4 蛋白) + T cell compartment.
IL-15 secretion significantly correlates with the up-regulated expression of CD4 (显示 CD4 蛋白) on memory CD4 (显示 CD4 蛋白) T cells that is associated with increased permissiveness to simian immunodeficiency virus infection.
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.