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抗Human IL12B 抗体:
抗Mouse (Murine) IL12B 抗体:
抗Rat (Rattus) IL12B 抗体:
Human Monoclonal IL12B Primary Antibody for IHC (fro), ELISA - ABIN2474931
Carter, Patel, Stanley, Ingham, Wadhwa, Bird, Thorpe, Selby, Banks: Production and characterization of monoclonal antibodies to human interleukin-12. in Hybridoma 1997
Show all 3 Pubmed References
Human Polyclonal IL12B Primary Antibody for ELISA, IHC - ABIN4325518
Sheth, De, Nolan, Friel, Duffy, Ricciardi, Miller-Graziano, Bankey: Heat shock protein 27 inhibits apoptosis in human neutrophils. in The Journal of surgical research 2001
Human Monoclonal IL12B Primary Antibody for FACS - ABIN4898082
Napoletano, Zizzari, Rughetti, Rahimi, Irimura, Clausen, Wandall, Belleudi, Bellati, Pierelli, Frati, Nuti: Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. in European journal of immunology 2012
Mouse (Murine) Polyclonal IL12B Primary Antibody for ELISA, WB - ABIN238549
Stäger, Maroof, Zubairi, Sanos, Kopf, Kaye: Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+ CD4+ T cells. in European journal of immunology 2006
Show all 2 Pubmed References
Human Monoclonal IL12B Primary Antibody for ELISA - ABIN2689727
DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. in The Journal of experimental medicine 1992
Human Polyclonal IL12B Primary Antibody for IHC (p), WB - ABIN2176964
Li, Dan, Nie, Hu, Gesang, Bianba, Ze, Ciren: CD14 knockdown reduces lipopolysaccharide-induced cell viability and expression of inflammation-associated genes in gastric cancer cells in vitro and in nude mouse xenografts. in Molecular medicine reports 2015
The anti-EGFR (显示 EGFR 抗体) viroplexes with IL-12 (显示 IL12A 抗体) and salmosin genes exhibited the most effective therapeutic efficacy in a mouse tumor model, especially when combined with doxorubicin.
baseline serum IL-12 levels were significantly higher in those pediatric hematopoietic stem cell transplantation recipients who did not develop acute graft versus host disease
Human neutrophil elastase (显示 ELANE 抗体) is involved in transactivation of TLR4 (显示 TLR4 抗体) through activation of DUOX-2 (显示 DUOX2 抗体)/EGFR (显示 EGFR 抗体) and synergistically enhances IL-12p40 production by macrophages stimulated with LPS (显示 IRF6 抗体).
our results suggested a significant association between IL-12B 3'-UTR (显示 UTS2R 抗体) and rs6887695 SNPs and ADs (显示 AGPS 抗体).
All the tested TLRAs induced greater infant IFN-alpha2 (显示 IFNA2 抗体) production compared to newborn and adult blood. In contrast, CpG induced greater IFN-gamma (显示 IFNG 抗体), IL-1beta (显示 IL1B 抗体), IL-4 (显示 IL4 抗体), IL-12p40, IL-10 (显示 IL10 抗体) and CXCL8 (显示 IL8 抗体) in newborn than in infant and adult blood.
Simultaneous elevated circulating levels of IL-18 (显示 IL18 抗体) and IL-12 (显示 IL12A 抗体) increased the event rate after 2 years in Coronary Artery Disease patients, independent of hyperglycemia
Single-nucleotide-polymorphisms of IL12B may be considered a high-risk factor for Takayasu arteritis in Chinese Han population
IL-12B -1188 C allele may be a protective factor against asthma in East Asians
The low expression of HDAC3 (显示 HDAC3 抗体) and overexpession of inflammatory cytokines (IL-18 (显示 IL18 抗体), IL-12 (显示 IL12A 抗体) and TNF-alpha (显示 TNF 抗体)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
Polymorphisms of IFNG (显示 IFNG 抗体), IL12B and IL12RB1 (显示 IL12RB1 抗体) genes in paracoccidioidomycosis Brazilian patients do not affect the susceptibility or resistance to the disease.
Data indicate that there was a differential transcription of 381 genes which changed greater than two fold in B1a of p40-/-IL-2Ralpha-/- mice.
this study shows that a systemic IL-12 (显示 IL12A 抗体) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (显示 IL12A 抗体) production is inhibited by TLR stimulation from the plasma membrane
Irradiation-induced IL-6 (显示 IL6 抗体) can decrease IL-12 (显示 IL12A 抗体) production through the inhibition of C-Rel (显示 NFkBP65 抗体) phosphorylation by the IL-6 (显示 IL6 抗体)/STAT3 (显示 STAT3 抗体) signaling pathway.
The IL-12 (显示 IL12A 抗体) response by dendritic cells against S. aureus is highly growth phase dependent.
the PI3K pathway mediated IL-12 (显示 IL12A 抗体) inhibition but did not interfere with the inhibition of IL-23 (显示 IL23A 抗体) or stimulation of IL-10 (显示 IL10 抗体).
Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.
this study demonstrates viral RNA analog-induced transcription synergy of Il6 (显示 IL6 抗体) and Il12b via IFN regulatory factor (IRF)1 (显示 IRF1 抗体) (TLR3 (显示 TLR3 抗体)-TIR domain-containing adaptor inducing IFN-beta (显示 TICAM1 抗体) [TRIF (显示 RNF138 抗体)] responsive), C/EBPbeta (显示 CEBPB 抗体) (TLR7 (显示 TLR7 抗体)-MyD88 (显示 MYD88 抗体) responsive), and JunB (显示 JUNB 抗体) (all responsive).
These findings reveal a critical role for IL-12 (显示 IL12A 抗体) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.
our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (显示 TNF 抗体), IL-6 (显示 IL6 抗体), IL-12p40, IL-1beta (显示 IL1B 抗体), and resulted in increased expression of the apoptosis initiator caspase-8 (显示 CASP8 抗体) and bcl2L1 (显示 BCL2L1 抗体).
The results showed that the expression of TNF-alpha (显示 TNF 抗体), iNOS (显示 NOS2 抗体), and IL-6 (显示 IL6 抗体) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (显示 IL12A 抗体) was unaffected.[IL-6 (显示 IL6 抗体), IL-12 (显示 IL12A 抗体)]
study investigated hypothesis that CD40 (显示 CD40 抗体) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (显示 NOS2 抗体) and IL-12p40 genes downstream of p38 (显示 MAPK14 抗体)
In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (显示 TLR7 抗体)/8 and TLR-9 (显示 TLR9 抗体) stimulation, which could potentially affect their response to vaccination and viral infection.
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, IL-12 subunit p40
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin 12, p40
, interleukin-12 beta chain
, interleukin-12 subunit beta
, natural killer cell stimulatory factor, 40 kD subunit
, CLMF p35
, IL-12 subunit p35
, cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12
, interleukin-12 subunit alpha
, IL-12 p40
, IL-23 subunit p40
, interleukin-12 p40
, interleukin-12 p40 subunit
, interleukin 12B
, interleukin-12 p35 subunit
, IL-12 p40 subunit
, interleukin 12 p40.b
, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
, interleukin 12 p40 subunit
, interleukin-12 p40 chain
, interleukin 12 40kDa subunit
, Cytotoxic lymphocyte maturation factor 40 kDa subunit
, Interleukin-12 subunit beta