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IL-12 receptor signalling in keratinocytes initiates a protective transcriptional programme that limits skin inflammation.
The authors found that the expressions of the mRNAs of both IL-12p35 and IL-12p40 were significantly reduced in the oxygen-induced retinopathy retinas compared to that of the room air-raised control. The results suggest that IL-12 plays important roles in inhibiting pathological retinal neovascularization.
IL-12p35 suppresses lymphocyte proliferation, induces expansion of IL-10 (显示 IL10 蛋白)-expressing and IL-35-expressing B cells and ameliorates autoimmune uveitis.
IL-35-transduced adipocyte-derived mesenchymal stem cells in vivo can enhance proliferation of CD4 (显示 CD4 蛋白)(+) CD25 (显示 IL2RA 蛋白)(+) Treg cells and suppress the function of effector T cells such as T helper (Th) 1 (显示 TH1L 蛋白), Th2 and Th17 cells and may reduce the development of allograft rejection.
findings show that IL-12 and other proinflammatory cytokines transduce signals through the TCR signalosome in a manner that requires Fyn activity and self-peptide-MHC (self-pMHC) interactions.
this study shows that a systemic IL-12 primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
These results suggest a correlation between CRMP2 (显示 DPYSL2 蛋白) phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta (显示 APP 蛋白) accumulation stage in AD model mice.
Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines.
Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.
Deficiency of IL-12p35 limited AMI (显示 CFD 蛋白)-induced cardiac injury by promoting pro-angiogenesis and anti-inflammatory functions of monocytes
The present study investigated the relationship of IL35 (显示 EBI3 蛋白) in patients with immunorelated hemocytopenia (IRH (显示 CXCL12 蛋白)). Serum level of IL35 (显示 EBI3 蛋白) was decreased in untreated patients with IRH (显示 CXCL12 蛋白) compared with remission patients (P<0.01) and was significantly associated with clinical indexes.
The overall results showed that cancer risk was increased by IL-12A rs568408 (GG versus GA + AA: P = 0.004; G versus A: P = 0.005) and IL-12B (显示 IL12B 蛋白) rs3212227 (AA versus AC + CC: P = 0.004; CC versus AA + AC: P = 0.03; A versus C: P = 0.007) polymorphisms. However, we failed to detect any significant associations between the IL-12A rs2243115 polymorphism and cancer risk in either the overall or the subgroup analyses.
IL-35 is a relatively newly discovered member of the IL-12 family which are unique in structure as they are dimer formed by two subunits; recent findings have shown abnormal expression of IL-35 in inflammatory autoimmune diseases and functional analysis suggested that IL-35 is critical in the onset and development of these diseases. [Review]
In the study, 250 ONFH patients and 228 matched healthy controls from Shandong Province were recruited to evaluate the influence of interleukin-10 (IL-10 (显示 IL10 蛋白)) rs1800872, IL-12 rs3212227 and tumor necrosis factor-(TNF-alpha (显示 TNF 蛋白)) rs1800629 polymorphism in osteonecrosis of the femoral head (ONFH). IL-12 rs3212227 AC genotype confer genetically susceptibility to ONFH in the Chinese Han population.
The results suggest IL12A genotype predict higher risk of death and progression, respectively, in NSCLC patients.
Pancreatic ductal carcinoma cells produce IL35 (显示 EBI3 蛋白) to recruit monocytes via CCL5 (显示 CCL5 蛋白) and induce macrophage to promote angiogenesis via expression of CXCL1 (显示 CXCL1 蛋白) and CXCL8 (显示 IL8 蛋白).
Polymorphisms of IFNL3 rs8099917 and IL12A rs568408 contribute to survival of HD patients, but not as independent factors.
The anti-EGFR (显示 EGFR 蛋白) viroplexes with IL-12 and salmosin genes exhibited the most effective therapeutic efficacy in a mouse tumor model, especially when combined with doxorubicin.
The findings suggest that not the IFN-gamma (显示 IFNG 蛋白) (+874) A/T but the IL-12 (-1188) A/C polymorphism is correlated with subacute sclerosing panencephalitis (SSPE), and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.
The results showed that the expression of TNF-alpha (显示 TNF 蛋白), iNOS (显示 NOS2 蛋白), and IL-6 (显示 IL6 蛋白) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6 (显示 IL6 蛋白), IL-12]
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
, IL-12 subunit p35
, cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12a p35 subunit
, interleukin-12 subunit alpha
, interleukin 12 p35 subunit
, IL-12, subunit p35
, IL35 subunit
, NF cell stimulatory factor chain 1
, NK cell stimulatory factor chain 1
, cytotoxic lymphocyte maturation factor 1, p35
, interleukin 12, p35
, interleukin-12 alpha chain
, natural killer cell stimulatory factor 1, 35 kD subunit
, interleukin 12 35kDa subunit
, interleukin 12 polypeptide 35
, natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35
, interleukin 12B
, interleukin-12 p35 subunit
, IL-12 p35
, interleukin 12
, Cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12 35kD subunit
, IL-12p35 subunit