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IL-12p35 suppresses lymphocyte proliferation, induces expansion of IL-10 (显示 IL10 蛋白)-expressing and IL-35-expressing B cells and ameliorates autoimmune uveitis.
IL-35-transduced adipocyte-derived mesenchymal stem cells in vivo can enhance proliferation of CD4 (显示 CD4 蛋白)(+) CD25 (显示 IL2RA 蛋白)(+) Treg cells and suppress the function of effector T cells such as T helper (Th) 1 (显示 TH1L 蛋白), Th2 and Th17 cells and may reduce the development of allograft rejection.
findings show that IL-12 and other proinflammatory cytokines transduce signals through the TCR signalosome in a manner that requires Fyn activity and self-peptide-MHC (self-pMHC) interactions.
this study shows that a systemic IL-12 primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
These results suggest a correlation between CRMP2 (显示 DPYSL2 蛋白) phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta (显示 APP 蛋白) accumulation stage in AD model mice.
Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines.
Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.
Deficiency of IL-12p35 limited AMI (显示 CFD 蛋白)-induced cardiac injury by promoting pro-angiogenesis and anti-inflammatory functions of monocytes
IL-12 immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.
There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.
The anti-EGFR (显示 EGFR 蛋白) viroplexes with IL-12 and salmosin genes exhibited the most effective therapeutic efficacy in a mouse tumor model, especially when combined with doxorubicin.
The findings suggest that not the IFN-gamma (显示 IFNG 蛋白) (+874) A/T but the IL-12 (-1188) A/C polymorphism is correlated with subacute sclerosing panencephalitis (SSPE), and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.
baseline serum IL-12 levels were significantly higher in those pediatric hematopoietic stem cell transplantation recipients who did not develop acute graft versus host disease
circulating mir-21 and expression of the IL-12p35 gene were observed significantly downregulated in current smokers with CAD.
Simultaneous elevated circulating levels of IL-18 (显示 IL18 蛋白) and IL-12 increased the event rate after 2 years in Coronary Artery Disease patients, independent of hyperglycemia
Epstein Barr Virus miRNAs collectively and specifically suppress release of proinflammatory cytokines such as IL-12, repress differentiation of naive CD4 (显示 CD4 蛋白)(+) T cells to Th1 (显示 TH1L 蛋白) cells.
HLA-B51 is a primary association marker in predisposition to Behcet disease, with IL-23R and IL12A being the additional strongest loci.
assembly-induced folding is key in IL-12 family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 cytokine
The plasma levels of interleukin-35 were significantly higher in the hepatocellular carcinoma patients than the controls.
Importantly, treatment of NK cells from HIV-infected patients with IL-12 reversed the multiple defects in binding, granule polarization, perforin (显示 PRF1 蛋白) content, and perforin (显示 PRF1 蛋白) release and restored anticryptococcal activity.
The results showed that the expression of TNF-alpha (显示 TNF 蛋白), iNOS (显示 NOS2 蛋白), and IL-6 (显示 IL6 蛋白) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6 (显示 IL6 蛋白), IL-12]
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
, IL-12 subunit p35
, cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12a p35 subunit
, interleukin-12 subunit alpha
, interleukin 12 p35 subunit
, IL-12, subunit p35
, IL35 subunit
, NF cell stimulatory factor chain 1
, NK cell stimulatory factor chain 1
, cytotoxic lymphocyte maturation factor 1, p35
, interleukin 12, p35
, interleukin-12 alpha chain
, natural killer cell stimulatory factor 1, 35 kD subunit
, interleukin 12 35kDa subunit
, interleukin 12 polypeptide 35
, natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35
, interleukin 12B
, interleukin-12 p35 subunit
, IL-12 p35
, interleukin 12
, Cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12 35kD subunit
, IL-12p35 subunit