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Mouse (Murine) IL-13 Protein expressed in Escherichia coli (E. coli) - ABIN1305069
Doherty, Kastelein, Menon, Andrade, Coffman: Modulation of murine macrophage function by IL-13. in Journal of immunology (Baltimore, Md. : 1950) 1994
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This study demonstrates that IL-13 serum levels are elevated in patients with insulin (显示 INS 蛋白) resistance without showing correlation with parameters of low-grade systemic inflammation.
Our findings suggest that IL-13 SNP rs20541 is significantly associated with AR risk in Asians but not in Caucasians. [meta-analysis]
genetic variants in IL-13, especially h0011 haplotype increased the risk of the prevalence of aggregate bronchitic symptoms in non-asthmatic children. It may also modify the effects of exposure to air pollutants on the prevalence of aggregate bronchitic symptoms.
These results demonstrate that histamine up-regulates the expression of TLR3 (显示 TLR3 蛋白) and secretion of IL-13 and MCP-1 (显示 CCL2 蛋白) in mast cells, thus identifying a new mechanism for the histamine inducing allergic response.
IL-13 enhances mesenchymal transition of pulmonary artery endothelial cells via down-regulation of miR (显示 MLXIP 蛋白)-424/miR (显示 MLXIP 蛋白)-503 in vitro.
Silencing DUOX1 by siRNA attenuated IL-13-mediated increases in superoxide, but did not reduce autophagy activities.
Local IL-10 (显示 IL10 蛋白) and IL-13 upregulation in IgG4-abdominal aortic aneurysms was related to Th2 and Treg-predominant cytokine balance.
this is the first study using population epidemiological methods to elucidate the role of gut (显示 GUSB 蛋白) microbiota-related dietary factors and polymorphisms in miRNA-binding site in IL13 in CRC (显示 CALR 蛋白).
Substitutions in the central immune regulator IL13 correspond to a polymorphism linked to asthma susceptibility in humans.
IL13 polymorphism rs1295686 (in complete linkage disequilibrium with functional variant rs20541) is associated with challenge-proven food allergy.
results demonstrate that IL-13 is a major regulator of radiation-induced lung injury and demonstrates that strategies focusing on IL-13 may be useful in screening for timely delivery of anti-IL-13 therapeutics.
Using a mouse model of Th2-mediated inflammation induced by OVA-allergen, this study observed elevated lung amounts of IL-13 and IL-4 (显示 IL4 蛋白) accompanied by increased autophagosome levels, determined by LC3BII protein levels and immunostaining.
Metaplasia induction and macrophage polarisation after parietal cell loss is coordinated through a cytokine signalling network of IL-33 (显示 IL33 蛋白) and IL-13, linking a combined response to injury by both intrinsic mucosal mechanisms and infiltrating M2 macrophages.
IL-13 is able to signal independent of the IL-4Ra (显示 IL4R 蛋白) chain in AD (atopic dermatitis), which may lead to the identification of molecular pathways downstream of IL-13 signaling that could be targeted in future therapies for AD.
the presence of interleukin-13 (IL-13), which can convert inflammatory into Ym1 (显示 CHI3L3 蛋白)+ alternatively activated macrophages, at (acinar-to-ductal metaplasia [ADM (显示 ADM 蛋白)]), which then gives rise to pancreatic intraepithelial neoplasia lesions, is reported.
Data indicate that interleukin-33 (IL-33 (显示 IL33 蛋白))-induced Interleukin-13 (IL-13) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (显示 EGFR 蛋白)) expression.
this study shows that environmental IL-13 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 (显示 IL4 蛋白) and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
this study shows that ST2 (显示 SULT2A1 蛋白) regulates early IL-13 production in fungus-induced allergic airway inflammation
These observations suggest that IL-4 (显示 IL4 蛋白) and IL-13 likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (显示 HAND1 蛋白) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 (显示 MMP1 蛋白) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
, T-cell activation protein P600