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Mouse (Murine) IL-13 Protein expressed in Escherichia coli (E. coli) - ABIN1305069
Doherty, Kastelein, Menon, Andrade, Coffman: Modulation of murine macrophage function by IL-13. in Journal of immunology (Baltimore, Md. : 1950) 1994
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Local IL-10 (显示 IL10 蛋白) and IL-13 upregulation in IgG4-abdominal aortic aneurysms was related to Th2 and Treg-predominant cytokine balance.
this is the first study using population epidemiological methods to elucidate the role of gut (显示 GUSB 蛋白) microbiota-related dietary factors and polymorphisms in miRNA-binding site in IL13 in CRC (显示 CALR 蛋白).
Substitutions in the central immune regulator IL13 correspond to a polymorphism linked to asthma susceptibility in humans.
IL13 polymorphism rs1295686 (in complete linkage disequilibrium with functional variant rs20541) is associated with challenge-proven food allergy.
SOCS1 (显示 SOCS1 蛋白) inhibits epithelial IL-13 signalling, supporting its key role in regulating Th2-driven eosinophilia in severe asthma
IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells
This meta-analysis suggests that the T allele of rs1800925 is associated with the increased risk of COPD (显示 ARCN1 蛋白) in both Asians and Caucasians, whereas rs20541 is associated with the risk of COPD (显示 ARCN1 蛋白) in Caucasians but not in Asians.
the IL13-1112 C/T (rs1800925) polymorphism does not predict responsiveness to neoadjuvant chemoradiotherapy or prognosis of Chinese Han patients with locally advanced rectal cancer .
Different genotype profiles of IL13 gene seem to influence the clinical pattern of disease expression mainly confined to the upper airways, as rhinitis, or including the lower airways, as asthma
secretion of IL-13 and amphiregulin (显示 AREG 蛋白) suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease.
Metaplasia induction and macrophage polarisation after parietal cell loss is coordinated through a cytokine signalling network of IL-33 (显示 IL33 蛋白) and IL-13, linking a combined response to injury by both intrinsic mucosal mechanisms and infiltrating M2 macrophages.
IL-13 is able to signal independent of the IL-4Ra (显示 IL4R 蛋白) chain in AD (atopic dermatitis), which may lead to the identification of molecular pathways downstream of IL-13 signaling that could be targeted in future therapies for AD.
the presence of interleukin-13 (IL-13), which can convert inflammatory into Ym1 (显示 CHI3L3 蛋白)+ alternatively activated macrophages, at (acinar-to-ductal metaplasia [ADM (显示 ADM 蛋白)]), which then gives rise to pancreatic intraepithelial neoplasia lesions, is reported.
Data indicate that interleukin-33 (IL-33 (显示 IL33 蛋白))-induced Interleukin-13 (IL-13) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (显示 EGFR 蛋白)) expression.
this study shows that environmental IL-13 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 (显示 IL4 蛋白) and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
this study shows that ST2 (显示 SULT2A1 蛋白) regulates early IL-13 production in fungus-induced allergic airway inflammation
These observations suggest that IL-4 (显示 IL4 蛋白) and IL-13 likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (显示 HAND1 蛋白) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
MIF (显示 MIF 蛋白)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (显示 GATA3 蛋白) expression and IL-13 production in the mesenteric lymph nodes
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (显示 TLR4 蛋白) signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 (显示 MMP1 蛋白) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
, T-cell activation protein P600