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Mouse (Murine) IL-13 Protein expressed in Escherichia coli (E. coli) - ABIN1305069
Doherty, Kastelein, Menon, Andrade, Coffman: Modulation of murine macrophage function by IL-13. in Journal of immunology (Baltimore, Md. : 1950) 1994
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Serum IL-5 (显示 IL5 蛋白) and IL-13 are reliable biomarkers for the blood eosinophilia asthma phenotype.
IL-13 suppressed cyp27b1 (显示 CYP27B1 蛋白) expression in CD14 (显示 NDUFA2 蛋白)(+) cells. IL-13 increased expression of miR (显示 MLXIP 蛋白)-19a in CD14 (显示 NDUFA2 蛋白)(+) cells. IL-13 suppresses cyp27b1 (显示 CYP27B1 蛋白) expression in peripheral CD14 (显示 NDUFA2 蛋白)(+) cells via up regulating miR (显示 MLXIP 蛋白)-19a expression.
Leptin (显示 LEP 蛋白) knockdown suppressed MUC5AC production and secretion induced by IL-13 in human bronchial epithelial cells.
demonstrate a strong association between the ratio of Acinetobacter to Proteobacteria and IL-13 production and the probability of IL-13 production after allergen exposure. IL-13 concentrations in serum were also significantly correlated with the diversity of bacterial DNA. Together, these results underscore the relationship between immune responses to allergens and bacterial exposure during perinatal development.
These observations suggest that mechanical stretch may induce an influx of Ca(2 (显示 CA2 蛋白)+) and up-regulation of IL-13 and MMP-9 (显示 MMP9 蛋白) expression in 16HBE cells via activation of TRPC1 (显示 TRPC1 蛋白)
Studies show that bronchoalveolar lavage fluid (BALF) soluble triggering receptor expressed on myeloid cells-1 (显示 TREM1 蛋白) (sTREM-1) levels do not discriminate between mild-to-moderate asthma and chronic obstructive pulmonary disease (COPD (显示 ARCN1 蛋白)), in contrast, the interleukin 6 (IL-6 (显示 IL6 蛋白))/interleukine 13 (IL-13) ratio measured in BALF effectively differentiated these two diseases.
The presented data substantiate the hypothesis that claudin-18 (显示 CLDN18 蛋白) is a central barrier-forming component of tight junctions and show that IL-13 downregulates claudin-18 (显示 CLDN18 蛋白). These data also suggest that the loss of claudin-18 (显示 CLDN18 蛋白) is associated with increased sensitization to aeroantigens and airway responsiveness
IL-12 pretreatment increased TCR-induced IFN-gamma, TNF-alpha, IL-13, IL-4 and IL-10 production. This suggests that prior exposure to IL-12 potentiates the TCR-induced release of a range of cytokines
Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (显示 IL4 蛋白) and IL-13, down-regulates matriptase (显示 ST14 蛋白) as well as prostasin (显示 PRSS8 蛋白) through phosphorylation of the transcriptional regulator STAT6 (显示 STAT6 蛋白)
investigated the role of six potentially functional variants of the IL4 (显示 IL4 蛋白), IL13, and IL4R (显示 IL4R 蛋白) genes in gastrointestinal cancer; both IL13 rs20541 and rs1800925 were not associated with gastrointestinal cancer risk for any of the genetic models and subgroup analyses [meta-analysis]
Data indicate that interleukin-33 (IL-33 (显示 IL33 蛋白))-induced Interleukin-13 (IL-13) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (显示 EGFR 蛋白)) expression.
this study shows that environmental IL-13 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 (显示 IL4 蛋白) and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
this study shows that ST2 (显示 SULT2A1 蛋白) regulates early IL-13 production in fungus-induced allergic airway inflammation
These observations suggest that IL-4 (显示 IL4 蛋白) and IL-13 likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (显示 HAND1 蛋白) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
MIF (显示 MIF 蛋白)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (显示 GATA3 蛋白) expression and IL-13 production in the mesenteric lymph nodes
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (显示 TLR4 蛋白) signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
Study found IL-13 to be critically involved in the development of chemical-induced asthma, as shown by using IL-13 KO mice, and more specifically in the effector phase as confirmed by anti- IL-13 antibody treatment.
these studies show that fibrosis, steatosis, cholestasis, and ductular reaction are simultaneously controlled but distinctly regulated by interleukin-13 signaling
Our data support that impaired clearance of inhaled allergens triggering IL-13 production by multiple cell types in the airways plays an important role in the pathogenesis of type 2 airway inflammation and suggests therapeutic improvement of mucociliary clearance as a novel treatment strategy for children with allergen-induced asthma.
T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 (显示 MMP1 蛋白) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
, T-cell activation protein P600