Use your antibodies-online credentials, if available.
Mouse (Murine) IL-13 Protein expressed in Escherichia coli (E. coli) - ABIN1305069
Doherty, Kastelein, Menon, Andrade, Coffman: Modulation of murine macrophage function by IL-13. in Journal of immunology (Baltimore, Md. : 1950) 1994
Show all 3 Pubmed References
This meta-analysis suggests that the T allele of rs1800925 is associated with the increased risk of COPD (显示 ARCN1 蛋白) in both Asians and Caucasians, whereas rs20541 is associated with the risk of COPD (显示 ARCN1 蛋白) in Caucasians but not in Asians.
the IL13-1112 C/T (rs1800925) polymorphism does not predict responsiveness to neoadjuvant chemoradiotherapy or prognosis of Chinese Han patients with locally advanced rectal cancer .
Different genotype profiles of IL13 gene seem to influence the clinical pattern of disease expression mainly confined to the upper airways, as rhinitis, or including the lower airways, as asthma
secretion of IL-13 and amphiregulin (显示 AREG 蛋白) suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease.
Increased baseline mRNA levels of the Th2-related cytokine IL-13 and the regulatory cytokine IL-10 (显示 IL10 蛋白) predicted a positive food challenge outcome.
These findings demonstrate that NF-kappaB (显示 NFKB1 蛋白)-mediated transcriptional mechanisms are critically involved in the IL-1beta (显示 IL1B 蛋白)-mediated IL-17C (显示 IL17C 蛋白) induction, and that IL-13 negatively regulates this induction by suppressing NF-kappaB (显示 NFKB1 蛋白)-based transcriptional activation.
These results suggested that IL-13 +1923C/T polymorphism contributed to the development of asthma.
IL13 AA of rs20541 and STAT4 (显示 STAT4 蛋白) TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 (显示 STAT4 蛋白) TT did not respond to high-dose ICSs.
The diagnostic performance of sputum IL-13 was superior to both sputum eosinophils and FeNO levels for the identification of well-controlled asthma. Sputum IL-13 levels could serve as a useful biomarker for asthma control assessment.
15LO1 inhibition (by short interfering RNA and chemical inhibitor) decreased IL-13-induced forkhead box protein A3 (FOXA3 (显示 FOXA3 蛋白)) expression and enhanced FOXA2 (显示 FOXA2 蛋白) expression. These changes were associated with reductions in both mucin 5AC and periostin (显示 POSTN 蛋白).
the presence of interleukin-13 (IL-13), which can convert inflammatory into Ym1 (显示 CHI3L3 蛋白)+ alternatively activated macrophages, at (acinar-to-ductal metaplasia [ADM (显示 ADM 蛋白)]), which then gives rise to pancreatic intraepithelial neoplasia lesions, is reported.
Data indicate that interleukin-33 (IL-33 (显示 IL33 蛋白))-induced Interleukin-13 (IL-13) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (显示 EGFR 蛋白)) expression.
this study shows that environmental IL-13 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 (显示 IL4 蛋白) and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
this study shows that ST2 (显示 SULT2A1 蛋白) regulates early IL-13 production in fungus-induced allergic airway inflammation
These observations suggest that IL-4 (显示 IL4 蛋白) and IL-13 likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (显示 HAND1 蛋白) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
MIF (显示 MIF 蛋白)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (显示 GATA3 蛋白) expression and IL-13 production in the mesenteric lymph nodes
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (显示 TLR4 蛋白) signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
Study found IL-13 to be critically involved in the development of chemical-induced asthma, as shown by using IL-13 KO mice, and more specifically in the effector phase as confirmed by anti- IL-13 antibody treatment.
these studies show that fibrosis, steatosis, cholestasis, and ductular reaction are simultaneously controlled but distinctly regulated by interleukin-13 signaling
T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 (显示 MMP1 蛋白) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
, T-cell activation protein P600