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either JC1 or DS1 C/EBP site is sufficient to mediate IFN beta-induced down-regulation of SIV long terminal repeat activity and virus replication in macrophages
Hepatitis A virus protein 2B suppresses beta interferon (显示 IFNA 蛋白) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt.
The data confirm the involvement of EHMT2 (显示 EHMT2 蛋白) in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 (显示 EHMT2 蛋白) inhibition.
The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3).
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 (显示 IRF3 蛋白) degradation.
These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes.
recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha (显示 IFNA 蛋白)/beta in bovine nasal fibroblasts and bronchoalveolar macrophages.
The effect of topical TREX1 (显示 TREX1 蛋白) knockdown and local interferon (显示 IFNA 蛋白) production on HIV transmission in human cervicovaginal explants and humanized mice, is reported.
The TBK1 (显示 TBK1 蛋白) Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1 (显示 TBK1 蛋白).
this study shows that poly I:C treated PAR-1 (显示 MARK2 蛋白)-/- mice given the thrombin (显示 F2 蛋白) inhibitor dabigatran etexilate exhibited less IFNbeta and CXCL10 (显示 CXCL10 蛋白) expression in the spleen and plasma
The data demonstrate that an atypical TLR7 (显示 TLR7 蛋白) signaling pathway contributes to type interferon-beta expression during Y. pestis infection and suggest that the TLR7 (显示 TLR7 蛋白)-driven type I IFN response plays an important role in determining the outcome of plague.
Long-term exposure to atmospheric particulates, PM2.5 up-regulated H3K4 and H3K9 methylation in IL-6 (显示 IL6 蛋白) and IFN-beta promoter regions through down-regulating Kdm6a (显示 KDM6A 蛋白) expression. The results suggest that short-term exposure to PM2.5 significantly enhances the survival rate of influenza A-contaminated mice, while long-term PM2.5 inhalation lowers the capacity of pulmonary macrophages to secrete IL-6 (显示 IL6 蛋白) and IFN-beta.
Extracellular ATP reduces the replication of VSV, Newcastle disease virus, murine leukemia virus and HSV in vivo and in vitro through the P2X7 receptor (显示 P2RX7 蛋白); ATP increases IFN-beta expression. Mechanistically, ATP facilitates IFN-beta secretion through P38 (显示 CRK 蛋白)/JNK (显示 MAPK8 蛋白)/ATF-2 (显示 ATF2 蛋白) signaling pathways, which are crucial in promoting antiviral immunity.
study reports that mitochondrial antiviral signaling protein (MAVS (显示 MAVS 蛋白)), -mediated IFN-alpha (显示 IFNA 蛋白)/beta production and IFNAR (显示 IFNAR1 蛋白) signaling are required for alloimmune responses to the human K1 Ag in a murine model of inflammation-induced alloimmunization
study identifies a novel role for RIPK1 (显示 RIPK1 蛋白) and RIPK3 (显示 RIPK3 蛋白), a pair of homologous serine/threonine kinases previously implicated in the regulation of necroptosis and pathologic tissue injury, in directing IFN-beta production in macrophages
results suggest that, in addition to its well-known signaling activity, IFN-beta may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties.
results show that resistance to HSV-1 in the trigeminal ganglia during acute infection is conferred in part by STING and IFN-alpha (显示 IFNA 蛋白)/beta signaling in both bone marrow-derived and -resident cells, which coalesce to support a robust HSV-1-specific CD8 (显示 CD8A 蛋白)(+) T cell response
this study shows that the IFN-beta/STAT1 (显示 STAT1 蛋白) pathway is dysregulated in inflammatory bowel disease
results demonstrate that Sphingosine 1-phosphate lyase (SPL (显示 SGPL1 蛋白)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (显示 IKBKE 蛋白) and SPL (显示 SGPL1 蛋白), which provides a mechanistic understanding of the pro-IFN activity of SPL (显示 SGPL1 蛋白)
This study demonstrates a novel pathway for elevated IFNbeta signaling in SLE that is not dependent on stimulation by immune complexes but rather is cell intrinsic and critically mediated by IFNbeta and MAVS (显示 MAVS 蛋白).
G45R mutation of NS1 (显示 PTPN11 蛋白) slightly decreased NS1 (显示 PTPN11 蛋白) binding to dsRNA but did not interfere with its suppression of RIG-I (显示 DDX58 蛋白)-mediated type I IFN production.
Upon influenza virus infection, DPF2 dysregulated IFN-beta induction and expression of cytokines/chemokines and antiviral proteins. This study provides evidence that influenza virus utilizes DPF2 to escape host innate immunity.
Overexpression of PKV VP3 blocked IFN-beta-induced activation of the STAT1 (显示 STAT1 蛋白)/STAT2 (显示 STAT2 蛋白)/IRF9 (显示 IRF9 蛋白) promoter in a dose-dependent manner.
Data suggest that EV71 infection in enterocytes does not inhibit phosphorylation of STAT1 (显示 STAT1 蛋白)/2 induced by IFN-beta, but p-STAT1 (显示 STAT1 蛋白)/2 transport into the nucleus is significantly blocked; EV71 infection in enterocytes down-regulates expression of KPNA1 (显示 KPNA1 蛋白) and induces degradation of cellular KPNA1 (显示 KPNA1 蛋白) via caspase-3 (显示 CASP3 蛋白). [EV17 = Enterovirus 71]
This study reveals that decreased induction of both PKR (显示 PKLR 蛋白) and p300 (显示 EP300 蛋白) proteins contribute to impaired induction of IFN-beta in Chronic obstructive pulmonary disease primary bronchial epithelial cells upon influenza infection.
Nuclear export of NSP1alpha of porcine reproductive and respiratory syndrome virus was necessary for its ability for IFN beta inhibition.
Porcine deltacoronavirus nsp5 (显示 SPECC1 蛋白), the 3C-like protease, inhibits interferon-beta production through the cleavage of NEMO (显示 IKBKG 蛋白).
Highly pathogenic Porcine reproductive and respiratory syndrome virus modulates Interferon-beta expression mainly through attenuating IRF-3 (显示 IRF3 蛋白) phosphorylation.
Porcine epidemic diarrhea virus nsp1 inhibited the IFN-beta and IRF3 (显示 IRF3 蛋白) promoter activities.
poIFIT3 plays a significant role in the clearance of swine influenza virus in pigs and potentiates IFN-beta production.
DDX41 (显示 DDX41 蛋白) is involved in the dsDNA- and dsDNA-virus-mediated type IFN-beta signaling pathway in porcine kidney cells.
VIral NS4 (显示 SOS1 蛋白) protein antagonizes beta interferon (显示 IFNA 蛋白) expression by targeting the NF-kappaB (显示 NFKB1 蛋白) essential modulator.
Swine IFN-beta promotes genetic mutation of porcine reproductive and respiratory syndrome virus.
Expression of LSm14A (显示 LSM14A 蛋白) in HEK293 or Marc (显示 CCL7 蛋白)-145 cells enhanced activities of IFN-beta and NF-kappaB (显示 NFKB1 蛋白) promoters, induced IFN-beta transcription, and potentiated IFN-beta promoter activation, indicating that LSm14A (显示 LSM14A 蛋白) is a potential signal molecule (显示 WNT4 蛋白) in the IFN-beta pathway.
Overall, data provide evidence for the possible role of PI3K in the activation of the transcription of IFN-alpha (显示 IFNA 蛋白)/beta by PRRSV; study concludes that PRRSV inhibits the induction of IFN-alpha (显示 IFNA 蛋白) in monocyte-derived dendritic cells by as yet undefined post-transcriptional mechanisms.
suppresses the growth of rat glioma cells
, fibroblast interferon
, interferon beta
, interferon, beta 1
, interferon beta-1
, interferon beta 1
, interferon type B
, interferon, beta 1, fibroblast
, IFN-alpha/beta receptor 2
, interferon alpha/beta receptor 2
, interferon, beta; receptor
, interferon-alpha/beta receptor 2
, interferon-alpha/beta receptor beta chain
, type I interferon receptor 2