Use your antibodies-online credentials, if available.
Only type-I interferon (显示 IFNA 蛋白) restricts viral replication of attenuated Measles virus (MV) Schwarz strain in mice, independently of the presence of hCD46 receptor.
A key role of the IL7 (显示 IL7 蛋白) and Interferon (显示 IFNA 蛋白) type I receptor axis in the regulation of intratumoral t-cell functions and in the development of primary breast tumor growth and metastasis.
Data, including data from studies in knockout and double-knockout mice, suggest complex and sex-specific roles of Ifnar1 and Ifnar2 (显示 IFNAR2 蛋白) in type 1 diabetes (T1D); female NOD mice develop T1D in absence of both Ifnar1 and Ifnar2 (显示 IFNAR2 蛋白), whereas male mice do not.
we uncovered that IFNAR1 expression in stromal benign cells functions to protect against progression of leukemia.
Concurrent ablation of Ifnar1 led to a modest attenuation of the CK1alpha (显示 CSNK1A1 蛋白)-null phenotype indicating that, although other CK1alpha (显示 CSNK1A1 蛋白) targets are likely to be important, IFNAR1 downregulation can contribute to the maintenance of the HSCs function.
Central nervous system signaling through IFNAR1 is a factor that is critical to neural injury after stroke.
Results show that removal of type-1 IFN signalling in the APPSWE/PS1DeltaE9 mouse model of AD confers a predominantly anti-inflammatory glial response and protects from cognitive decline. However this phenotype does not correlate with alterations in amyloid deposition and only a modest reduction in Abeta (显示 APP 蛋白) monomer levels.
transfusion-induced differentiation of IFNAR1(-/-) B cells into germinal center B cells and plasma cells was significantly reduced, compared to WT B cells. This study demonstrates that B cells require signaling from IFN-alpha (显示 IFNA 蛋白)/beta to produce alloantibodies to the human KEL glycoprotein in mice.
These data suggest that plasmacytoid dendritic cells producing IFN-alpha (显示 IFNA 蛋白) and IL-33 (显示 IL33 蛋白) play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis.
type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine (显示 CCL1 蛋白) expression including CCL2 (显示 CCL2 蛋白).
HCV-1b core protein-induced miR (显示 MLXIP 蛋白)-93-5p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the miR (显示 MLXIP 蛋白)-93-5p-IFNAR1 axis regulates STAT1 (显示 STAT1 蛋白) phosphorylation.
Relapsing-remitting multiple sclerosis patients manifested a statistically higher expression level of IFNAR1 than their normal counterparts.
cellular kinase, casein kinase 1alpha (CK1alpha (显示 CSNK1A1 蛋白)), is crucial for IAV HA-induced degradation of both IFNGR1 (显示 IFNGR1 蛋白) and IFNAR1.
The authors find that UCHL3 (显示 Uchl3 蛋白) regulates COPS5 (显示 COPS5 蛋白)-dependent deneddylation of Cullin1, which is an essential component of SCF (显示 KITLG 蛋白)(beta-TrCP (显示 BTRC 蛋白)) complex and associated with SCF (显示 KITLG 蛋白)(beta-TrCP (显示 BTRC 蛋白)) activities. The authors further demonstrate that UCHL3 (显示 Uchl3 蛋白) upregulates the levels of SCF (显示 KITLG 蛋白)(beta-TrCP (显示 BTRC 蛋白)) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity.
Low IFNAR1 expression is associated with peritoneal metastasis in gastric cancer.
the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy.
Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche.
These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication.
On one hand, hepatitis B virus activates MMP-9 (显示 MMP9 蛋白) in infected patients and leukocytes. On the other hand, MMP-9 (显示 MMP9 蛋白) facilitates hepatitis B virus replication through repressing IFN/JAK (显示 JAK3 蛋白)/STAT (显示 STAT1 蛋白) signaling, IFNAR1 function, and IFN-alpha (显示 IFNA 蛋白) action.
this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo (显示 MITF 蛋白) in Estonian patients
Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 (显示 IFNA2 蛋白) generates type I IFN competitive antagonists.
The complete 168,835 bp insert sequence of a porcine BAC clone harboring the IFNAR1 gene was determined.
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
interferon alpha/beta receptor 1
, interferon receptor
, soluble receptor
, interferon-alpha receptor 1
, putative interferon-alpha/beta receptor alpha chain
, interferon receptor 1
, interferon (alpha, beta and omega) receptor 1
, interferon alpha/beta receptor 1-like
, IFN-alpha/beta receptor 1
, INF-a receptor
, interferon-alpha/beta receptor 1
, type I interferon receptor 1
, alpha-type antiviral protein
, beta-type antiviral protein
, cytokine receptor class-II member 1
, cytokine receptor family 2 member 1
, interferon-alpha/beta receptor alpha chain
, interferon-beta receptor 1
, interferon (alpha and beta) receptor 1
, interferon, alpha; receptor
, Interferon-alpha/beta receptor alpha chain