IFNAR1 蛋白 (IFNAR1)产品概述

Full name:: Interferon (Alpha, beta and Omega) Receptor 1 蛋白 (IFNAR1)

在www.antibodies-online.cn可供23 Interferon (Alpha, beta and Omega) Receptor 1 (IFNAR1) 蛋白的10不同的供货商。再加上，我们可以发和 IFNAR1 试剂盒 (15)和数多这个蛋白质的别的产品。总共260 IFNAR1产品已列进来了。

别名:: AVP, CD118, Ifar, IFN-alpha-REC, IFN-R-1, IFNAR, IFNAR1, IFNBR, IFRC, Infar

列出全部蛋白	基因	基因ID	UniProt
	IFNAR1	15975	P33896
	IFNAR1	3454	P17181
	IFNAR1	288264
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Mouse (Murine) Interferon (Alpha, beta and Omega) Receptor 1 (IFNAR1) interaction partners

Data, including data from studies in knockout and double-knockout mice, suggest complex and sex-specific roles of Ifnar1 and Ifnar2 (显示 IFNAR2 蛋白) in type 1 diabetes (T1D); female NOD mice develop T1D in absence of both Ifnar1 and Ifnar2 (显示 IFNAR2 蛋白), whereas male mice do not.
we uncovered that IFNAR1 expression in stromal benign cells functions to protect against progression of leukemia.
Concurrent ablation of Ifnar1 led to a modest attenuation of the CK1alpha (显示 CSNK1A1 蛋白)-null phenotype indicating that, although other CK1alpha (显示 CSNK1A1 蛋白) targets are likely to be important, IFNAR1 downregulation can contribute to the maintenance of the HSCs function.
Central nervous system signaling through IFNAR1 is a factor that is critical to neural injury after stroke.
Results show that removal of type-1 IFN signalling in the APPSWE/PS1DeltaE9 mouse model of AD confers a predominantly anti-inflammatory glial response and protects from cognitive decline. However this phenotype does not correlate with alterations in amyloid deposition and only a modest reduction in Abeta (显示 APP 蛋白) monomer levels.
transfusion-induced differentiation of IFNAR1(-/-) B cells into germinal center B cells and plasma cells was significantly reduced, compared to WT B cells. This study demonstrates that B cells require signaling from IFN-alpha (显示 IFNA 蛋白)/beta to produce alloantibodies to the human KEL glycoprotein in mice.
These data suggest that plasmacytoid dendritic cells producing IFN-alpha (显示 IFNA 蛋白) and IL-33 (显示 IL33 蛋白) play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis.
type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine (显示 CCL1 蛋白) expression including CCL2 (显示 CCL2 蛋白).
this study shows that the presence of IFN-alpha (显示 IFNA 蛋白) at antigen sensitization activates an IDO1 (显示 IDO1 蛋白)/TGF-beta (显示 TGFB1 蛋白)-dependent anti-inflammatory program that upon antigenic rechallenge prevents inflammation via plasmacytoid dendritic cells
these studies demonstrate an important role for type I IFN in skin fibrosis, and they provide a rationale for IFNAR1 inhibition in scleroderma

Human Interferon (Alpha, beta and Omega) Receptor 1 (IFNAR1) interaction partners

HCV-1b core protein-induced miR (显示 MLXIP 蛋白)-93-5p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the miR (显示 MLXIP 蛋白)-93-5p-IFNAR1 axis regulates STAT1 (显示 STAT1 蛋白) phosphorylation.
Relapsing-remitting multiple sclerosis patients manifested a statistically higher expression level of IFNAR1 than their normal counterparts.
cellular kinase, casein kinase 1alpha (CK1alpha (显示 CSNK1A1 蛋白)), is crucial for IAV HA-induced degradation of both IFNGR1 (显示 IFNGR1 蛋白) and IFNAR1.
The authors find that UCHL3 (显示 Uchl3 蛋白) regulates COPS5 (显示 COPS5 蛋白)-dependent deneddylation of Cullin1, which is an essential component of SCF (显示 KITLG 蛋白)(beta-TrCP (显示 BTRC 蛋白)) complex and associated with SCF (显示 KITLG 蛋白)(beta-TrCP (显示 BTRC 蛋白)) activities. The authors further demonstrate that UCHL3 (显示 Uchl3 蛋白) upregulates the levels of SCF (显示 KITLG 蛋白)(beta-TrCP (显示 BTRC 蛋白)) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity.
Low IFNAR1 expression is associated with peritoneal metastasis in gastric cancer.
the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy.
Downregulation of IFNAR1 in tumor stroma stimulated colorectal cancer development and growth, played a key role in formation of the immune-privileged niche.
These results suggest that miR-29a, upregulated during RSV infection, is a negative regulator of IFNAR1 and is critical for respiratory syncytial virus NS1-induced virus replication.
On one hand, hepatitis B virus activates MMP-9 (显示 MMP9 蛋白) in infected patients and leukocytes. On the other hand, MMP-9 (显示 MMP9 蛋白) facilitates hepatitis B virus replication through repressing IFN/JAK (显示 JAK3 蛋白)/STAT (显示 STAT1 蛋白) signaling, IFNAR1 function, and IFN-alpha (显示 IFNA 蛋白) action.
this study shows that single nucleotide polymorphism in IFNAR1 gene is associated with female vitiligo (显示 MITF 蛋白) in Estonian patients

Cow (Bovine) Interferon (Alpha, beta and Omega) Receptor 1 (IFNAR1) interaction partners

Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 (显示 IFNA2 蛋白) generates type I IFN competitive antagonists.

Pig (Porcine) Interferon (Alpha, beta and Omega) Receptor 1 (IFNAR1) interaction partners

The complete 168,835 bp insert sequence of a porcine BAC clone harboring the IFNAR1 gene was determined.

蛋白简介IFNAR1

蛋白简介

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.

Alternative names and synonyms associated with IFNAR1

interferon alpha and beta receptor subunit 1 (IFNAR1)
interferon-alpha/beta receptor alpha chain-like (ifnar1)
interferon (alpha and beta) receptor 1 (Ifnar1)
interferon alpha and beta receptor subunit 1 (Ifnar1)
interferon alpha/beta receptor 1 (LOC609830)

AVP 蛋白
CD118 蛋白
Ifar 蛋白
IFN-alpha-REC 蛋白
IFN-R-1 蛋白
IFNAR 蛋白
IFNAR1 蛋白
IFNBR 蛋白
IFRC 蛋白
Infar 蛋白

Protein level used designations for IFNAR1

, , , , , , , , , , , , , , , , , , , , , , , , interferon alpha/beta receptor 1 interferon receptor soluble receptor interferon-alpha receptor 1 putative interferon-alpha/beta receptor alpha chain interferon receptor 1 interferon (alpha, beta and omega) receptor 1 interferon alpha/beta receptor 1-like IFN-R-1 IFN-alpha/beta receptor 1 IFN-alpha/betaR INF-a receptor interferon-alpha/beta receptor 1 type I interferon receptor 1 CRF2-1 alpha-type antiviral protein beta-type antiviral protein cytokine receptor class-II member 1 cytokine receptor family 2 member 1 interferon-alpha/beta receptor alpha chain interferon-beta receptor 1 interferon (alpha and beta) receptor 1 IFN-alpha-REC interferon, alpha; receptor Interferon-alpha/beta receptor alpha chain

GENE ID	SPECIES
395665	Gallus gallus
458516	Pan troglodytes
699604	Macaca mulatta
100136116	Oncorhynchus mykiss
100137245	Papio anubis
100410306	Callithrix jacchus
100443118	Pongo abelii
100583382	Nomascus leucogenys
100230358	Taeniopygia guttata
15975	Mus musculus
3454	Homo sapiens
288264	Rattus norvegicus
609830	Canis lupus familiaris
282257	Bos taurus
396658	Sus scrofa
100715784	Cavia porcellus
443126	Ovis aries

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