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These data suggest that increased IFN-alpha8 (显示 IFNa14 蛋白) activity may promote the loss of T cells by accelerating cell turnover and activation-induced cell death while decreasing the renewal of T cells by inhibiting the proliferative effect of IL-7 (显示 IL7 蛋白).
IFN-alpha8 (显示 IFNa14 蛋白) and -alpha10 most potently enhanced expression of IFN-gamma (显示 IFNG 蛋白), IL-2 (显示 IL2 蛋白), and IL-4 (显示 IL4 蛋白).
variation at IFNA2 (显示 IFNA2 蛋白) -173 and IFNA8 -884 conditions reduced IFN-alpha (显示 IFNA 蛋白) production, and increased susceptibility to SMA (显示 SMN1 蛋白) and mortality
Data describe the species specificity of IFN-alphas, the residues in murine IFN-alpha4 that preclude strong affinity interactions with human IFNAR1 (显示 IFNAR1 蛋白) and 2, and residues in human IFN-alpha8 (显示 IFNa14 蛋白) that resemble a receptor interactive domain in murine IFN-alpha4.
Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.
Produced by macrophages, IFN-alpha have antiviral protein kinase and an oligoadenylate synthetase.
, interferon alpha type 201
, interferon alpha-8
, interferon alpha-B
, interferon alpha-B'
, interferon alpha-B2
, leIF B
, interferon, alpha 8
, IFN-alpha B