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抗Human GNAQ 抗体:
抗Rat (Rattus) GNAQ 抗体:
抗Mouse (Murine) GNAQ 抗体:
Chicken Monoclonal GNAQ Primary Antibody for IF, WB - ABIN968914
Dutt, Kjoller, Giel, Hall, Toksoz: Activated Galphaq family members induce Rho GTPase activation and Rho-dependent actin filament assembly. in FEBS letters 2002
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Chicken Monoclonal GNAQ Primary Antibody for IF, WB - ABIN968915
Li, Iyengar: Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation. in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 3 Pubmed References
Human Monoclonal GNAQ Primary Antibody for ELISA, WB - ABIN516106
Sánchez-Fernández, Cabezudo, Caballero, García-Hoz, Tall, Klett, Michnick, Mayor, Ribas: Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector. in The Journal of biological chemistry 2016
Human Polyclonal GNAQ Primary Antibody for ELISA, WB - ABIN4315225
Ngai, Inngjerdingen, Berge, Taskén: Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation. in BMC immunology 2009
Nine of 13 cases (69%) of anastomosing hemangiomas harbored a somatic mutation at GNAQ codon 209
It is therefore concluded that Gnaq plays a pivotal role in antioxidation in neural cells. A possible mechanism for this would be that the overexpressed Gnaq inhibits the cellular damaging effect mediated by NF-kappaB and Erk1/2 signal pathways.
Parathyroid hormone (显示 PTH 抗体) controls bone and kidney homeostasis via GNAS (显示 GNAS 抗体) and Gq-G11 (显示 STK19 抗体) heterotrimeric G proteins. (Review)
There were no significant differences in the prevalence of GNAQ and GNA11 (显示 GNA11 抗体) mutations between patients with or without metastatic disease
we report a previously unknown role for Gaq in maintenance of MLL (显示 MLL 抗体)-AF9 (显示 MLLT3 抗体)-induced acute myeloid leukemia (显示 BCL11A 抗体) leukemia
Study demonstrated that the GNAQ p.R183Q mutation resides within endothelial cells in Sturge-Weber syndrome (SWS) brain lesions, and that the SWS brain endothelial cells can be isolated and expanded in culture and further confirm that the GNAQ p.R183Q mutation is present in brain endothelial cells.
Phospholipase C beta connects G protein signaling with RNA interference. (Review)
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (显示 SOX10 抗体) expression and presence of the BRAF (显示 BRAF 抗体) V600E mutation.
Mutations in GNAQ and GNA11 (显示 GNA11 抗体) genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
These results indicate that the mechanism by which Galphaq and PLC (显示 HSPG2 抗体)-beta3 mutually regulate each other is far more complex than a simple, two-state allosteric model and instead is probably kinetically determined.
The Galphas (显示 GNAS 抗体) and Galphaq peptides adopt different orientations in beta2-AR and V1AR (显示 AVPR1A 抗体), respectively. The beta2-AR/Galphas (显示 GNAS 抗体) peptide interface is dominated by electrostatic interactions, whereas the V1AR (显示 AVPR1A 抗体)/Galphaq peptide interactions are predominantly hydrophobic.
The phylogenetic trees reveal that porcine Gnaq, is evolutionarily close to the human homolog.
atomic structure of GRK2 (显示 ADRBK1 抗体) in complex with Galphaq and Gbetagamma, in which the activated Galpha (显示 SUCLG1 抗体) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [g alphaq]
these data highlighted the critical role of Galphaq in regulating Th17 differentiation and multiple sclerosis pathogenesis
in colonic crypt cultures, the GLP-1 (显示 GCG 抗体) secretion induced by such Gq + Gs GPR40 (显示 FFAR1 抗体) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (显示 TGFB1 抗体) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (显示 IL33 抗体) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the impaired working memory in forebrain-specific Perk (显示 EIF2AK3 抗体) knockout mice may stem from altered Gq protein-coupled intracellular Ca(2 (显示 CA2 抗体)+) dynamics in cortical pyramidal neurons.
Galphaq regulates the development of rheumatoid arthritis by modulating Th1 (显示 HAND1 抗体) differentiation
Fluid shear stress acts on the Galphaq-ERK5 (显示 MAPK7 抗体) signaling pathway to upregulate Cyclin B1 (显示 CCNB1 抗体) and CDK1 (显示 CDK1 抗体) expression, thereby resulting in MC3T3-E1 cell proliferation.
activation of the Gq-membrane-associated estrogen receptors rapidly stimulates hypothalamic paraventricular nucleus CRH (显示 CRH 抗体) neurons by suppressing the M-current and potentiating glutamatergic neurotransmission
cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion.
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.
, guanine nucleotide-binding protein G(q) subunit alpha
, guanine nucleotide-binding protein alpha-q
, G alpha q
, guanine nucleotide binding protein alpha q subunit
, guanine nucleotide binding protein, alpha q polypeptide
, guanine nucleotide regulatory protein G alpha q
, heterotrimeric guanine nucleotide-binding protein alpha q subunit
, guanine nucleotide-binding protein G(q) alpha subunit