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Human EPOR ELISA Kit for Sandwich ELISA - ABIN414365
Villafuerte, Macarlupú, Anza-Ramírez, Corrales-Melgar, Vizcardo-Galindo, Corante, León-Velarde: Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness. in Journal of applied physiology (Bethesda, Md. : 1985) 2014
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EPO (显示 EPO ELISA试剂盒)-mediated EPOR signaling reduced the viability of myeloma cell lines and of malignant primary plasma cells in vitro
this study shows that EPO (显示 EPO ELISA试剂盒) could directly promote tumor progression via EPO (显示 EPO ELISA试剂盒) receptor-expressing macrophages
No evidence of in vivo activation of the Epo-R in WAT could be documented despite detectable levels of Epo-R mRNA. CONCLUSION: Thus, in contradiction to animal studies, Epo (显示 EPO ELISA试剂盒) treatment within a physiological relevant range in humans does not exert direct effects in a subcutaneous WAT.
Our results suggest that EPO (显示 EPO ELISA试剂盒)/EPOR pathway promotes gastric cancer formation, proliferation, migration, and decreases apoptosis
These results suggest that both EpoR-positive and EpoR-negative cancer cells could be regulated by exogenous Epo (显示 EPO ELISA试剂盒). However, an increased response to erythropoietin (显示 EPO ELISA试剂盒) was observed in the EpoR-positive cells. Thus, erythropoietin (显示 EPO ELISA试剂盒) increases the risk of tumor progression in colon cancer and should not be used to treat anemia in this type of cancer.
Overexpression of EPOR is associated with clear cell renal cell carcinoma.
HIF-1alpha (显示 HIF1A ELISA试剂盒) and EPO-R may be an indicator of the aggressiveness of invasive breast cancers
In multivariate survival analysis, age, Epo (显示 EPO ELISA试剂盒) and EpoR were independent prognostic factors related to overall survival in hepatocellular carcinoma.
These results identify EPOR as the secondbona fidehydroxylation-dependent substrate of VHL (显示 VHL ELISA试剂盒) that potentially influences oxygen homeostasis and contributes to the complex genotype-phenotype correlation in VHL (显示 VHL ELISA试剂盒) disease.
We report for a first time that functional EpoR is expressed in human rhabdomyosarcoma cell lines as well as by primary tumors from RMS patients.
CIS (显示 CISH ELISA试剂盒) interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 (显示 STAT5A ELISA试剂盒) and ERK (显示 EPHB2 ELISA试剂盒).
these results have revealed that phosphorylation of Tyr (显示 TYR ELISA试剂盒)-343, Tyr (显示 TYR ELISA试剂盒)-460, and Tyr (显示 TYR ELISA试剂盒)-464 in EpoR underlies JAK2 (显示 JAK2 ELISA试剂盒) V617F mutant-induced tumorigenesis.
A solution NMR study of the mouse erythropoietin receptor (mEpoR) comprising the transmembrane domain and the juxtamembrane regions reconstituted in dodecylphosphocholine (DPC) micelles.
These data indicate that EpoR signaling is associated with cardiac remodeling following chronic iron deficiency.
We propose that the CID (显示 CENPA ELISA试剂盒)-dependent dimerization system combined with the EpoR intracellular domain and the Gata1 (显示 GATA1 ELISA试剂盒) gene regulatory region generates a novel peroral strategy for the treatment of anemia.
transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles
EpoR and its activity are downstream effectors of Klotho (显示 KL ELISA试剂盒) enabling it to function as a cytoprotective protein against oxidative injury.
Expression of EPOR in rod photoreceptors, Muller cells, and amacrine, horizontal, and ganglion cells of the peripheral retina is not required for the maturation, function, and survival of these cells in aging tissue.
Data indicate a Cbl (显示 CBL ELISA试剂盒)/p85 (显示 ECM1 ELISA试剂盒)/epsin-1 (显示 EPN1 ELISA试剂盒) pathway in erythropoietin receptor (EpoR) endocytosis.
Data from knockout mice suggest that adipose tissue-specific disruption of EPO (显示 EPO ELISA试剂盒) receptor does not alter adipose tissue expansion, adipocyte morphology, insulin (显示 INS ELISA试剂盒) resistance, inflammation, or angiogenesis.
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
, Erythropoietin receptor
, type I single-transmembrane cytokine receptor
, erythropoietin receptor-like