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Conformational changes in the GM-CSF (显示 CSF2 蛋白) receptor suggest a molecular mechanism for affinity conversion and receptor signaling.
Our cohort broadens the spectrum of knowledge about the clinical variability and genotype-phenotype correlations of juvenile PAP (显示 REG3A 蛋白), and illustrates the favorable outcome of WLL treatment in severely affected patients
A possible relationship between dysfunction of the granulocyte-macrophage colony stimulating factor receptor, mapping to the pseudoautosomal X-Y region, may exist in myelodysplastic patients with initially lymphocytic Sweet syndrome.
Studies indicate the action of GM-CSF (显示 CSF2 蛋白) can be inhibited by at least two approaches: inhibition by GM-CSF (显示 CSF2 蛋白) neutralising antibodies, or blockade of GM-CSF (显示 CSF2 蛋白) binding to its receptor by antibodies against the GM-CSF receptor alpha chain (显示 FCGRT 蛋白) CSF2Ralpha.
The GM-CSF (显示 CSF2 蛋白) Ralpha were ubiquitously but not uniformly expressed in neurons throughout the brain and downregulation in brain in patient with alzheimenr disease.
This study reveals a novel functional role of clathrin-coated structure in GMR signaling and the oncogenesis of JAK2V617F.
Identify defective expression and function of CD116 as a distinguishing feature of IBD and implicate an associated defect in innate immune responses toward granulocyte-macrophage colony-stimulating factor (显示 CSF2 蛋白).
The expression rate of GM-CSFR in myelodysplastic syndrome patients was significantly higher than in aplastic anemia patients and controls.
67-kDa laminin receptor (显示 RPSA 蛋白) expression influenced the characteristics of leukemia cells toward an aggressive phenotype and increased the number of granulocyte-macrophage colony-stimulating factor (显示 CSF2 蛋白) receptors
Data show that Deletion of the Ig-like domain of GM-CSFRalpha abolished direct GM-CSF (显示 CSF2 蛋白) binding and decreased growth signalling in the presence of hbetac.
a STOP mutation in the GM-CSFRalpha chain, leading to a complete and specific deficiency in GM-CSF (显示 CSF2 蛋白) signaling, is reported.
GM-CSFRalpha levels peaked between E13 and E15 in the brain.
Loss of the CSF2RA gene may be a critical mutation explaining the high incidence of loss of sex chromosomes associated with the t(8;21)(q22;q22) translocation.
ability to detect GM-CSF (显示 CSF2 蛋白) receptor expression in experimental studies should greatly facilitate the analysis of its role in immune pathologies[GM-CSF receptor alpha]
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
, GM-CSF receptor alpha subunit
, colony stimulating factor 2 receptor alpha subunit
, granulocyte-macrophage colony-stimulating factor receptor alpha chain
, granulocyte-macrophage colony-stimulating factor receptor subunit alpha
, colony stimulating factor 2 receptor alpha chain