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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN2017902
Djalilian, Caicedo, Lessan, Grami, Le, Spellman, Pambuccian, Hall, Low, Ondrey: Efficacy of an osmotic pump delivered, GM-CSF-based tumor vaccine in the treatment of upper aerodigestive squamous cell carcinoma in rats. in Cancer immunology, immunotherapy : CII 2007
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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN803898
Carreño, Pacheco, Gutierrez, Jacobelli, Kalergis: Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells. in Immunology 2010
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Mouse (Murine) CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN803901
Bråve, Ljungberg, Boberg, Rollman, Isaguliants, Lundgren, Blomberg, Hinkula, Wahren: Multigene/multisubtype HIV-1 vaccine induces potent cellular and humoral immune responses by needle-free intradermal delivery. in Molecular therapy : the journal of the American Society of Gene Therapy 2005
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Human CSF2 Protein expressed in Escherichia coli (E. coli) - ABIN934919
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
Upregulation of GM-CSF and M-CSF (显示 CSF1 蛋白) production by endothelial cells, an effect that appears to be mediated by NF-kappaB (显示 NFKB1 蛋白) and to be independent of IL-1 (显示 IL1A 蛋白), may be an additional mechanism through which IL-33 (显示 IL33 蛋白) contributes to inflammatory activation of the vessel wall.
Oral and periodontal innate immunity is affected by HIV viremia and ART. GCF (显示 GUCY2F 蛋白) IL-8 (显示 IL8 蛋白), G-CSF (显示 CSF3 蛋白), as well as serum IL-8 (显示 IL8 蛋白), MCP-1 (显示 CCL2 蛋白) and GM-CSF may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use.
Data suggest that the intratumoral GM-CSF expression, as a potentially independent prognostic biomarker for recurrence, might improve conventional clinical and pathologic analysis to refine outcome prediction for clinically localized clear-cell renal cell carcinoma (显示 MOK 蛋白) (ccRCC) patients after surgery.
High GM-CSF expression is associated with breast Cancer.
In gastric cancer (GC), tumour-derived GM-CSF activated neutrophils and induced neutrophil PD-L1 (显示 CD274 蛋白) expression via Janus kinase (JAK (显示 JAK3 蛋白))-signal transducer and activator of transcription 3 (STAT3 (显示 STAT3 蛋白)) signalling pathway. The activated PD-L1 (显示 CD274 蛋白)(+) neutrophils effectively suppressed normal T-cell immunity in vitro and contributed to the growth and progression of human GC in vivo.
The IL-3 (显示 IL-3 蛋白)/ GM-CSF effected on the myofibroblastic differentiation of human adipose derive stromal cells (hASCs) as well as it did on human dermal fibroblasts (HDFs).
Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 (显示 IL5 蛋白) and GM-CSF.
Data suggest that the methylotrophic yeast Pichia pastoris is an effective recombinant host for heterologous granulocyte-macrophage colony-stimulating factor (rhGM-CSF) production.
Letter: Knockdown of either filaggrin (显示 FLG 蛋白) or loricrin (显示 LOR 蛋白) increases the productions of interleukin (IL)-1alpha, IL-8 (显示 IL8 蛋白), IL-18 (显示 IL18 蛋白) and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes.
Impaired RASGRF1 (显示 RASGRF1 蛋白)/ERK (显示 EPHB2 蛋白)-mediated GM-CSF response characterizes CARD9 (显示 CARD9 蛋白) deficiency in French-Canadians.
TRAF6 (显示 TRAF6 蛋白) is also required for GM-CSF-induced ubiquitination and activation of Akt (显示 AKT1 蛋白).
CSF2 stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (显示 MAPK1 蛋白)-dependent MTOR (显示 FRAP1 蛋白) signal transduction cascades.
In conclusion, our study confirms the pathogenic role of GM-CSF in colitis-associated colorectal cancer development. GM-CSF favors tumor-permissive microenvironment by inducing MDSC generation and recruiting them into colonic tissues.
these data demonstrate that GM-CSF levels during radiotherapy can be used as a prognostic biomarker for lung and esophageal cancer
this study demonstrates that epithelial-derived GM-CSF is a critical early signal during allergic sensitization to cockroach allergen
These impaired macrophage functions in leukemic mice were significantly corrected by IL-3 (显示 IL-3 蛋白) and GM-CSF treatment indicating the therapeutic benefit of these two cytokines in leukemia.
Both IL-6 (显示 IL6 蛋白) protein production and transcript levels were downregulated by RA in respiratory tract epithelial cells (LETs) , but upregulated in macrophages (MACs). RA also increased transcript levels of MCP-1 (显示 CPT1B 蛋白), GMCSF, and IL-10 (显示 IL10 蛋白) in MACs, but not in LETs. Conversely, when LETs, but not MACs, were exposed to RA
T-GM-CSF and -IL-3 (显示 IL-3 蛋白) significantly, and reciprocally, blunted receptor binding and myeloid progenitor cell proliferation activity of both FL-GM-CSF and -IL-3 (显示 IL-3 蛋白) in vitro and in vivo
Results indicate GM-CSF as both a key contributor to the pathogenesis of MI and a potential therapeutic target.
GM-CSF is required for the normal balance of leukocyte subsets, including granulocytes, B cells, and naive vs. effector T cells. There was an approximately 3-fold increase in the percentages of granulocytes in Csf2-/- PBMCs. The presence of maximal experimental autoimmune encephalomyelitis in the complete absence of GM-CSF revealed that GM-CSF is not an obligate effector molecule in all forms of EAE.
chemerin (显示 RARRES2 蛋白) inhibited nuclear factor-kappaB activation and the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (显示 IL2 蛋白) (IL-6 (显示 IL6 蛋白)) by tumor cells and tumor-associated endothelial cell, respectively, via its receptors, and consequently, MDSC induction was impaired, leading to restoration of antitumor T-cell response and decreased tumor angiogenesis.
It was concluded that CSF2 can act as a developmental programming agent but alone is not able to abolish the adverse effects of in vitro production on fetal characteristics.
These results demonstrated that bovine colonic cells seem capable to respond to E. bovis merozoite I infection by the upregulation of CXCL10 (显示 CXCL10 蛋白) and GM-CSF gene transcription.
Data suggest exposure to maternal CSF2 from D5-D7 of development is fundamentally different for female/male blastocysts with respect to embryo elongation, characteristics of transcriptome/methylome, and endometrial interferon tau secretion at D15 (显示 MRPL16 蛋白).
The increase in calving rate caused by CSF2 treatment involves, in part, more extensive development of extraembryonic membranes and capacity of the conceptus to secrete IFNT2 at day 15 of pregnancy.
immunolocalization studies confirmed the presence of granulocyte-macrophage colony stimulating factor(GM-CSF) in the germ cell line in bovine and human testes and addition of GM-CSF enhances several parameters of sperm motility
the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 (显示 PTGS2 蛋白) and GM-CSF during the peri (显示 PLIN1 蛋白)-attachment period in the cow.
CSF2 affect embryonic development and enhance embryo competence for posttransfer survival.
Data indicate that differentially expressed IL-17 (显示 IL17A 蛋白), IL-22 (显示 IL22 蛋白), and IL-23 (显示 IL23A 蛋白) levels are associated with K-ras (显示 HRAS 蛋白) in a stage-specific fashion along colorectal cancer progression and an association was established between mutant K-ras (显示 HRAS 蛋白) and GM-CSF and IFN-gamma (显示 IFNG 蛋白).
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.
, granulocyte-macrophage colony-stimulating factor
, colony stimulating factor 2 (granulocyte-macrophage)
, colony-stimulating factor
, granulocyte-macrophage colony stimulating factor 2
, put. GM-CSF
, granulate-macrophage stimulating factor
, granulocyte-macrophage stimulation factor