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Human CNTF Receptor alpha Protein expressed in Baculovirus infected Insect Cells - ABIN2003719
Sleeman, Anderson, Lambert, Yancopoulos, Wiegand: The ciliary neurotrophic factor and its receptor, CNTFR alpha. in Pharmaceutica acta Helvetiae 2000
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This study demonstrated that hypomethylation leading to CNTFRalpha up-regulation, together with autocrine expression of CNTF, was involved in glioma growth regulation.
The family-based study showed no association between the CNTFR rs7036351, NET rs3785143 polymorphisms, and attention-deficit hyperactivity disorder.
R28E mutation in CNTF abrogatesIL-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130/ LIFR.
gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated.
Data indicate that CNTFRalpha plays a role in the formation or maintenance of tumor-initiating cells in gliomas, is a marker that correlates with histological grade, may underlie treatment resistance in some cases, and is a potential therapeutic target.
expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth.
Data show that variants in CNTFR were significantly associated with a lower age at onset of the eating disorders.
interactions of CNTFR with LIFR and gp130 in vitro
C174T polymorphism in exon 9 of CNTFR is significantly associated with fat-free mass in men and women, with concomitant differences in muscular strength.
Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha.
In liver CNTFRalpha serves as a key modulator in regulating PI3K and AMP-activated protein kinase dynamically under CNTF stimulation, resulting in the increase of glucose uptake and translocation of glucose transporter 4.
These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130.
Study proposes a novel insight that miR-696 down-regulates C2C12 cell myogenesis by inhibiting CNTFRalpha expression.
The data, along with previous work indicating no effect of muscle specific ciliary neurotrophic factor alpha (CNTFRalpha) depletion on motor innervation, suggest that motor neuron and muscle CNTFRalpha function in concert to maintain motor neuron axons.
CNTFR expression was downregulated by androgen in the inguinoscrotal fat pad suggesting that the genitofemoral nerve may be masculinised to control gubernacular migration in the inguinoscrotal phase of testicular descent by a negative regulating mechanism in mouse embryos .
The data of this study data suggest that CNTF receptors may promote adult motor neuron survival.
CNTF-Ralpha and CNTF are present in the pre-and post-synaptic sites of the neuromuscular junction.
Data show that CNTF receptor alpha subunit, CNTFRalpha, signaling in leptin-responsive neurons is not required for endogenous maintenance of energy balance.
identification of neuropoietin as a new ligand with with important implications for murine nervous system development
CNTF-CNTFRalpha activates the JAK/STAT pathway leading to enhanced Cx43 expression and intercellular coupling
It is suggested that the loss of CNTFRalpha from axons renders RGCs unresponsive to CNTF, thereby contributing to regenerative failure and death, while its appearance on glia may promote glial scarring.
Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth.
CNTF receptor signaling, likely by the MNs themselves, can play an essential role in MN survival. This role is independent of any developmental contributions CNTF receptor signaling makes to MN survival or function.
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
CNTF receptor subunit alpha
, ciliary neurotrophic factor receptor subunit alpha
, CNTFR alpha
, ciliary neurotrophic factor receptor alpha
, ciliary neurotrophic factor receptor subunit alpha preproprotein
, GPA receptor subunit alpha
, growth promoting activity (GPA) receptor alpha; GPARalpha
, growth-promoting activity receptor subunit alpha
, ciliary neurotrophic factor receptor
, ciliary neurotrophic factor receptor subunit alpha-like