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This study demonstrated that hypomethylation leading to CNTFRalpha up-regulation, together with autocrine expression of CNTF, was involved in glioma growth regulation.
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The family-based study showed no association between the CNTFR rs7036351, NET rs3785143 polymorphisms, and attention-deficit hyperactivity disorder.
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R28E mutation in CNTF abrogatesIL-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130/ LIFR.
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gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated.
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Data indicate that CNTFRalpha plays a role in the formation or maintenance of tumor-initiating cells in gliomas, is a marker that correlates with histological grade, may underlie treatment resistance in some cases, and is a potential therapeutic target.
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expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth.
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Data show that variants in CNTFR were significantly associated with a lower age at onset of the eating disorders.
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interactions of CNTFR with LIFR and gp130 in vitro
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C174T polymorphism in exon 9 of CNTFR is significantly associated with fat-free mass in men and women, with concomitant differences in muscular strength.
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Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC and CNTFRalpha.
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In liver CNTFRalpha serves as a key modulator in regulating PI3K and AMP-activated protein kinase dynamically under CNTF stimulation, resulting in the increase of glucose uptake and translocation of glucose transporter 4.
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These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130.