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This study indicates that CISH functions as a conserved in vivo target and regulator of STAT5 in the control of embryonic hematopoiesis.
the type II SOCS genes (CISH, SOCS1-3) are particularly relevant to immune regulation in fish
identified P2RX2, KCNQ5, ERBB3 and SOCS3 to be associated with the progression of age-related hearing impairment
CIS interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 and ERK.
Studies indicate that suppressors of cytokine signaling (SOCS) proteins CIS, SOCS1, and SOCS3 can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4(+) T cells and the maturation of CD8(+) T cells.
CISH rs414171 and rs6768300 variants might be associated with protection from pulmonary tuberculosis in Zahedan, Southeast Iran.
This study showed that there was significantly increased levels of CIS mRNA in elderly and Alzheimer's disease brains.
Data indicate that CIS protein stability is regulated through multiple mechanisms, including ubiquitination and interaction with Elongin B/C proteins, whereas CIS functional inhibition of PRLR signaling is dependent on the Elongin B/C interaction.
SOCS single nucleotide polymorphism is associated with breast cancer.
Study in Chinese Han population confirms that previously identified variants of CISH are associated with susceptibility to pulmonary tuberculosis.
CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect.
Two SNPs (rs414171 and rs2239751) in the CISH gene were associated with persistent HBV infection in Han Chinese population
two genetic variants in CISH gene appear to increase susceptibility to TB in Chinese Han population
CISH promoter rs414171 and rs809451 polymorphisms may play a vital role in mediating individual susceptibility to tuberculosis
methylation of SOCS1, SOCS2, SOCS3 and CISH is infrequent in Ph-ve MPN.
data suggest FXR-mediated upregulation of cytokine inducible SH2-containing protein (CISH) may play an important role in the homeostasis of cytokine signal networks and be beneficial to control cytokine-associated inflammatory diseases
In GH transduction defect, abnormal GH signalling may be caused by over-expression of CIS, which may increase degradation of GHR
Suppressors of both cytokine signaling SOCS7 and cytokine-inducible SH2 protein (CIS) are expressed constitutively at higher levels in LNCaP-S17 (prostate cancer) cells than in LNCaP-C3 cells.
Study indicates the vital role of CISH single nucleotide polymorphism (SNP)-292A>T variant to hepatitis B virus infection in a Vietnamese population.
The authors conclude that Mycobacterium tuberculosis infection induces development of Tregs from CCR4(+) cells through a process that depends on PD-1and CISH.
Variants of CISH are associated with susceptibility to diseases caused by diverse infectious pathogens.
Low level of CISH expression in various tissues suggests that it is a novel prospective marker for diagnosis of colon cancer.
CISH mediates control of M. tuberculosis in mice early after infection via regulation of innate immune mechanisms.
this study identifies CIS as a critical negative regulator of IL-15 signaling in NK cells
Data show that cytokine inducible SH2-containing protein Cish is induced upon T cell receptor stimulation and in the tumor microenvironment.
Results show that CISH has no non-redundant functions in beta cell proliferation or glucose homeostasis during pregnancy in mice. Socs2 might compensate for the loss of Cish during pregnancy.
CIS has a critical role in controlling the proallergic generation of helper T cells.
CISH expression at the later stage of dendritic cell development triggers the shutdown of DC progenitor cell proliferation and facilitates DC differentiation into a potent stimulator of CTLs.
CIS and SOCS3 play a role as negative feedback inhibitors of PRL action; Inhibition of CIS and SOCS3 expression by glucocorticoids contributes to the positive effect of glucocorticoids on PRL-induced STAT5 activation.
Induction of CIS in response to EPO stimulation depends on Stat5 but not MAP kinase or PI 3-kinase. Overexpression negatively regulates EPO-mediated cell proliferation, Stat5 phosphorylation, & activation of a Stat-dependent luciferase reporter.
CIS negatively regulates signaling at two levels, apoptosis and proliferation, and thereby sets a threshold for signal transduction
IL-6 inhibits hepatic GH signaling by upregulating Cis and Socs-3, which may involve activation of STAT3.
histone acetylation and chromatin remodeling events occurring during transcriptional activation of the endogenous murine Cis gene, a STAT5 target gene
The desensitization of the JAK2/STAT5b GH signaling pathway observed in pregnant mice would then be mainly related to increased CIS levels rather than to the other regulatory proteins examined.
C-terminal part of the CIS SOCS-box is required for functional interaction with the cytokine receptor motifs examined.
RACK1 has a role in protecting cancer cells from apoptosis by regulating the degradation of BimEL, which together with CIS could play an important role of drug resistance in chemotherapy
Elongin B/C recruitment regulates substrate binding by CIS
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
cytokine inducible SH2-containing protein
, cytokine-inducible SH2-containing protein
, cytokine inducible SH2 containing protein
, cytokine inducible SH2-containing protein A
, twinfilin, actin-binding protein, homolog 1, like
, Cytokine-inducible SH2-containing protein
, cytokine-inducible inhibitor of signaling type 1B
, suppressor of cytokine signaling
, cytokine-inducible SH2 protein
, cytokine inducible SH2-containing protein 1