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Transplantation experiments demonstrated that med14 and brg1 (显示 SMARCA4 抗体) are required directly in neural crest cells. Analysis of med14; brg1 (显示 SMARCA4 抗体) double mutant embryos suggested the existence of strong genetic interaction between members of Mediator and BAF (显示 BANF1 抗体) complexes.
Functional analysis implicates TNRC6A, NAT10 (显示 NAT10 抗体), MED14, and WDR5 (显示 WDR5 抗体) in RNA-mediated transcriptional activation.
This results from a dramatically enhanced ability of MED14-containing complexes to associate with Pol II (显示 0 抗体).
VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF (显示 CSF2 抗体) and MED14
DRIP150 binds to ISGF3 (显示 STAT1 抗体) and regulates transcription
CRSP2 gene is expressed in the retina and its exact genomic location is on Xp11.4 between DXS1368 and DXS993
Coactivation of ERalpha (显示 ESR1 抗体) by DRIP150 in ZR-75 cells is NR box-independent and requires a novel sequence with putative alpha-helical structure.
MED14 and MED1 (显示 MED1 抗体) are used by glucocorticoid receptor (显示 NR3C1 抗体) in a gene-specific manner, providing a mechanism for promoter selectivity by glucocorticoid receptor (显示 NR3C1 抗体)
Coactivator that enhances estrogen receptor alpha (显示 ESR1 抗体)- and specificity protein (SP)-1 (显示 PSG1 抗体)-mediated transactivation in breast cancer cells.
MED14 constitutes a novel anchoring point between Mediator and the N-terminal domain of PPARgamma (显示 PPARG 抗体) that is necessary for functional PPARgamma (显示 PPARG 抗体)-mediated recruitment of Mediator and transactivation of PPARgamma (显示 PPARG 抗体) subtype-specific target genes.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
, mediator complex subunit 14
, cofactor required for Sp1 transcriptional activation, subunit 2
, mediator of RNA polymerase II transcription subunit 14
, cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
, mediator of RNA polymerase II transcription subunit 14-like
, CRSP complex subunit 2
, RGR1 homolog
, activator-recruited cofactor 150 kDa component
, cofactor required for Sp1 transcriptional activation, subunit 2 (150kD)
, human homolog of yeast RGR1
, thyroid hormone receptor-associated protein complex 170 kDa component
, thyroid hormone receptor-associated protein complex component TRAP170
, transcriptional co-activator CRSP150
, vitamin D receptor-interacting protein complex component DRIP150
, vitamin D3 receptor-interacting protein complex 150 kDa component
, cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa)
, hypothetical protein