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HEYL rs784621 AA genotype is associated with poor response to therapy in Non-small Cell Lung Cancer.
LSD1 (显示 KDM1A 蛋白) directly associates with the promoter of the HEYL gene.
repression of TGFbeta (显示 TGFB1 蛋白) signaling by Notch (显示 NOTCH1 蛋白) acting through HEYL may promote initiation of breast cancer
Repression of androgen receptor (显示 AR 蛋白) activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch (显示 NOTCH1 蛋白) effectors.
In this study, we analyzed the effects of HESR1 (显示 HEY1 蛋白), -2, and -3 on DAT1 expression in human neuroblastoma (显示 ARHGEF16 蛋白) SH-SY5Y cells
HeyL null mice do not exhibit an obvious skeletal phenotype demonstrating that HeyL is dispensable for skeletal homeostasis.
These results indicate that Hesr1 (显示 HEY1 蛋白) and Hesr3 are essential for the generation of adult satellite cells and for the maintenance of skeletal muscle homeostasis.
This study demonistrated that HeyL promotes neuronal differentiation of neural progenitor cells by activating proneural genes and by inhibiting the actions of other Hes (显示 ATCAY 蛋白) and Hey family members.
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
, class B basic helix-loop-helix protein 33
, hairy-related transcription factor 3
, hairy/enhancer-of-split related with YRPW motif 3
, hairy/enhancer-of-split related with YRPW motif-like protein
, hairy and enhance of split related 3
, hairy and enhancer of split-related protein 3
, basic helix-loop-helix transcription factor heyL