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Human EGLN2 Protein expressed in HEK-293 Cells - ABIN2720027
Lin, Li, Xing, Hu, Liang, Han, Wang, Hawke, Wang, Zhang, Wei, Ma, Park, Zhou, Zhou, Hu, Zhou, Marks, Liang, Hung, Lin, Yang: The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. in Nature cell biology 2016
comparative analysis of phd1, 2, and 3 expression in Xenopus laevis
4-bp Insertion/deletion Polymorphism within the Promoter of EGLN2 is associated with breast cancer.
Our study provided initial evidence that the insertion/deletion polymorphism rs10680577 may play a functional role in the development of CRC in the Chinese population
EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to the progression of triple negative breast cancer.
In advanced-stage Hodgkin's Lymphoma patients strong cytoplasmic PHD1 expression in Reed-Sternberg cells was associated with poor relapse-free survival among patients treated with involved-field radiotherapy and advanced-stage patients treated with doxorubicin, bleomycin, vinblastine and darcabazine and involved-field radiotherapy.
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.
This study provides new information relating to the possible mechanism of therapeutic action of hydroxylase inhibitors that has been reported in pre-clinical models of intestinal and hepatic disease.
PHD1 is phosphorylated by CDK2, CDK4 and CDK6 at Serine 130.
siRNA-mediated knockdown of PHD1 inhibited glucose-stimulated insulin secretion in pancreatic Beta cells.
EglN2 associates with the NRF1-PGC1alpha complex and controls mitochondrial function in breast cancer
rs3733829 in the EGLN2 gene is significantly associated with the risk of COPD in Chinese populations of Hainan province.
Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia
study conducted to investigate the association between gastric cancer (GC) susceptibility with a 4-bp insertion/deletion polymorphism (rs10680577) in the proximal promoter of EGLN2; findings showed that the heterozygote and the homozygote 4-bp del/del confer a significantly increased risk of GC
Data indicate that the prolyl hydrolase 1 (PHD1) rs10680577 polymorphism is associated with the risk of non-small cell lung cancer in a Chinese population.
PHD-1 played an important role in hypoxic response pathway of trophoblast through modulating the level of HIF-2alpha.
PHD1 could induce cell cycle arrest in lung cancer cells, resulting in the suppression of cell proliferation.
Results show that variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk.
The diminished expression of PHD1 and PHD2 and elevated level of FIH protein in cancerous tissue compared to histopathologically unchanged colonic mucosa was not associated with DNA methylation within the CpG islands of the PHD1, PHD2 and FIH genes.
By modulating Cep192 levels, PHD1 thereby affects the processes of centriole duplication and centrosome maturation and contributes to the regulation of cell-cycle progression.
Onconeuronal antigen Cdr2 correlates with HIF prolyl-4-hydroxylase PHD1 and worse prognosis in renal cell carcinoma.
Findings provided strong evidence for the hypothesis that rs10680577 contributes to hepatocarcinogenesis, possibly by affecting RERT-lncRNA structure and subsequently EGLN2 expression.
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.
EGL nine homolog 2
, egl nine homolog 2
, Egl nine homolog 2
, EGL nine (C.elegans) homolog 2
, egl nine homolog 2 (C. elegans)
, egl nine homolog 2-like
, HIF-prolyl hydroxylase 1
, hypoxia-inducible factor prolyl hydroxylase 1
, immediate early response 4
, prolyl hydroxylase domain-containing protein 1
, HIF-1alpha prolyl-4-hydroxylase-1
, estrogen-induced tag 6