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Four single nucleotide polymorphisms in two genes in the PGE2 family, PTGES2 and PTGER4 (显示 PTGER4 蛋白), were significantly associated with primary graft dysfunction after lung transplantation.
high immunoreactivity of mPGES-2 in pyramidal neurons of AD brains indicates that it might have a potential role in the functional replacement of cytosolic PGES (显示 PTGES 蛋白) or inactive mPGES-1 (显示 PTGES 蛋白) in later stages of Alzheimer disease
Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression
role in regulating interferon-gamma (显示 IFNG 蛋白)-dependent gene expression
110Cys is essential in the active site of membrane-associated prostaglandin E synthase-2
Transactivators GBF1 and CCAAT/enhancer-binding protein-beta (显示 CEBPB 蛋白) physically interact to induce interferon-gamma (显示 IFNG 蛋白)-regulated transcription; a 37-aa long peptide derived from the GBF1 protein can associate with C/EBP-beta (显示 CEBPB 蛋白) in an IFN-inducible manner.
alphaTOS inhibits COX (显示 COX8A 蛋白) activity, thereby inhibiting PGE2 production in human lung epithelial cells
study obtained evidence from two Caucasian study populations that the His298-allele of PTGES2 Arg298His confers to reduced risk of type 2 diabetes
Carbonyl reductase-1 (CBR1 (显示 CBR1 蛋白)), microsomal prostaglandin E synthase-1 (显示 PTGES 蛋白) and 2 (mPGES-1 (显示 PTGES 蛋白), mPGES-2), cytosolic prostaglandin E synthase (cPGES (显示 PTGES3 蛋白)), aldoketoreductase (AKR1C1 (显示 DDH 蛋白)) and prostaglandin F synthase (AKR1C3 (显示 AKR1C3 蛋白)) were all expressed in hair follicles.
risk-reducing effects of the minor His allele of the prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism could be mediated partly by lowered body mass index (BMI)
mPGES-2 deletion enhanced streptozotocin (STZ)-induced liver toxicity possibly via GLUT2-mediated STZ uptake, independently of diabetes mellitus in mice.
increased expression of miR (显示 MLXIP 蛋白)-146a in bone marrow-derived mesenchymal stem cells correlated with inhibition of prostaglandin E2 synthase-2 and inhibition of prostaglandin E2 release.
In the urogenital system, membrane-associated PGES-2 was highly expressed in the renal cortex, followed by the renal medulla and ovary, with lower levels in the ureter, bladder and uterus.
Study suggests that in hypertensive mice, there are (a) significant microanatomic variations in the pulmonary, renal, and cardiac distribution and cellular localization of mPGES-2 and no differences in expression between genders.
Analysis of the mPGES-2 deficient mouse lines does not substantiate the contention that mPGES-2 is a PGE (显示 LIPF 蛋白)(2) synthase.
This article reviews the involvement of the PGE(2), Wnt, and BMP pathways in the development of gastric cancer.
PGE (显示 LIPF 蛋白)(2) protects the pulmonary vasculature from remodeling during allergen-induced pulmonary inflammation
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene.
prostaglandin E synthase 2
, microsomal prostaglandin E synthase 2
, prostaglandin E synthase 2-like
, GATE-binding factor 1
, gamma-interferon-activated transcriptional element-binding factor 1
, membrane-associated prostaglandin E synthase 2
, microsomal prostaglandin E synthase-2