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Tumor suppressor activity of Protein kinase C-delta.[review]
Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review]
Data suggest a targeted therapy and early medical intervention for protein kinase C delta (PKCdelta) could be a useful option for breast cancer cases complicated with type 2 diabetes mellitus (T2DM) or hyperglycemia.
NSC606985 produced a dose-dependent subcellular activation of PKCdelta. The dose-dependent dual action of NSC is mediated at least in part through the differential subcellular activation of castration-resistant prostate cancer (CRPC) LAPC4 cells.
PKC-delta expression is associated with KIT expression and the prognosis of patients with adenoid cystic carcinomas (AdCCs), suggesting that PKC-delta may be a potential therapeutic target for AdCCs.
Taken together, our findings suggest that TM-PKCdelta interaction may contribute to cardiovascular disorders by affecting monocye differentiation, which may develop future therapeutic applications.
PKC-delta played as a protective role in squamous cell carcinomas partly by down-regulating p63 (显示 RPE65 蛋白), leading to the suppression of squamous cell carcinomas cell proliferation
Activated PKCdelta interacts with the polymerase subunit PB2 and phospho-regulates NP oligomerization and RNP (显示 RNPC3 蛋白) assembly during Influenza A virus infection.
NRF2 (显示 GABPA 蛋白) Ser40 phosphorylation was inhibited in Crif1 (显示 GADD45GIP1 蛋白)-deficient bone marrow multipotent mesenchymal stromal cells even in the presence of three kinds of PKC (显示 PRRT2 蛋白) agonists, suggesting that CRIF1 (显示 GADD45GIP1 蛋白) might co-activate PKC-delta to phosphorylate NRF2 (显示 GABPA 蛋白) Ser40.
PKCdelta has an overall negative influence on platelet function in response to collagen, while, following PAR (显示 JTB 蛋白) stimulation, PKCdelta has a positive effect on platelet function. PKCdelta has different roles in platelet activation, aggregation and thrombus formation. Review.
These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.
Our key findings provide novel insights into the mechanism of action of heterotrimeric complex (PKCdelta-TIRAP (显示 TIRAP 蛋白)-p38 (显示 CRK 蛋白)) in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages.
sustained PKCdelta activation drives sustained microglial inflammatory responses and concomitant dopaminergic neurotoxicity consequently leading to neurobehavioral deficits
spinal PKCdelta has a role in the development of chronic pain in SCD (显示 SCD 蛋白), which may become a potential target for pharmacological interventions
K8/K18 (显示 KRT18 蛋白)-dependent PKCdelta- and ASMase (显示 SMPD1 蛋白)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (显示 KRT18 蛋白) loss.
MALAT1 recruits splice factor serine-arginine-rich splice factor 2 (SRSF2 (显示 SRSF2 蛋白)) to promote alternative splicing of PKCdeltaII.
SphK1 (显示 SPHK1 蛋白) dependent PKC-delta activation plays an important role in promoting NF-kappaB (显示 NFKB1 蛋白) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta activation might be a potential therapeutic strategy for this disease.
PKCdelta activity exerts a dual role through the autophagy mechanism, decreasing proliferative capacity of mammary tumor cells but also regulating tumor stem cell self-renewal.
alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta-mediated GLUT (显示 SLC1A3 蛋白) translocation that may be specific to the alpha(1A)-AR subtype.
Study shows that PRKCD influences corticotroph cell viability, POMC (显示 POMC 蛋白) and ACTH (显示 POMC 蛋白) expression suggesting that PRKCD plays an important role in restraining corticotroph cell proliferation and function.
Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2 (显示 FGF2 蛋白)) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 (显示 FGF2 蛋白) regulates IFNT production in trophoblasts by acting through PRKCD
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (显示 NOS3 蛋白) post-translational modification
stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
Protein kinase (显示 CDK7 蛋白) Cdelta-dependent phosphorylation of syndecan-4 (显示 SDC4 蛋白) regulates cell migration.
Activation of PKC induces the translocation of Nrf2 (显示 NFE2L2 蛋白) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
PKC-delta (显示 PRKCG 蛋白) mediates the apoptotic processes through ROS (显示 ROS1 蛋白)-dependent caspase-3 (显示 CASP3 蛋白) activation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
protein kinase C delta VIII
, protein kinase C delta type
, tyrosine-protein kinase PRKCD
, protein kinase C delta variant IX
, protein kinase C, delta IV
, protein kinase C, delta V
, protein kinase C[d]
, protein kinase-delta2
, protein kinase C, delta
, protein kinase C delta type-like
, protein kinase C delta