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expression of PLA2s (显示 PLA2G2A 蛋白)-IIE and -V correlates with the development of calcification as well as the expression of pro-osteogenic molecules in human aortic valves
sPLA(2 (显示 PLA2G2A 蛋白)) -IIE regulates lipolysis in adipocytes, likely through the ERK (显示 EPHB2 蛋白)/HSL (显示 LIPE 蛋白) signaling pathway
Single-nucleotide polymorphism in PLA2G2E gene is associated with ulcerative colitis.
promotes stimulus-induced arachidonic acid release and prostaglandin (PG) production similar to those elicited by HSPG (显示 HSPG2 蛋白)-dependent sPLA(2 (显示 PLA2G2A 蛋白))s, suggesting that this enzyme plays a role in the inflammatory process.
two skin sPLA2s (显示 PLA2G2D 蛋白), hair follicular sPLA2-IIE and epidermal sPLA2-IIF (显示 PLA2G2F 蛋白), play non-redundant roles in distinct compartments of mouse skin, underscoring the functional diversity of multiple sPLA2s (显示 PLA2G2D 蛋白) in the coordinated regulation of skin homeostasis and diseases.
PLA2G2E altered minor lipoprotein phospholipids, phosphatidylserine and phosphatidylethanolamine, and moderately facilitated lipid accumulation in adipose tissue and liver.
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
phospholipase A2, group IIE
, group IIE secretory phospholipase A2
, phosphatidylcholine 2-acylhydrolase 2E
, GIIE sPLA2