Caspase-2 Inhibitor Z-VDVAD-FMK

ABIN412390 产品详细信息, 供应商: Log in to see
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 A caspase-4 inhibitor
序列 Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
产品特性 PubChem CID: 44135215
A synthetic peptide that irreversibly inhibits activity of caspase-2. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
纯度 > 98 % by HPLC
Chemical Name Z-VDVAD-FMK, Caspase-2 Inhibitor, Z-VDVAD-fluoromethylketone
Formula C₃₂H₄₆FN₅O₁₁
Permeability Cell-permeable
Solubility DMSO
分子量 695.7 g/mol
应用备注 We recommend using 1000-5000X dilutions for inhibiting caspase-2 activity in Jurkat cell culture (e.g., Add 0.2-1 µL to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
限制 仅限研究用
状态 Liquid
浓度 10 mM
注意事项 Protect from light and moisture
储存条件 -20 °C
有效期 12 months
 image for Caspase-2 Inhibitor Z-VDVAD-FMK (ABIN412390) Caspase-2 Inhibitor Z-VDVAD-FMK
有引用在: Chen, Liou, Chen, Chen, Hu, Wang, Lin: "Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation." in: The Journal of biological chemistry, Vol. 288, Issue 17, pp. 11689-704, 2013 (PubMed).

Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).