ATM Kinase Inhibitor, KU-55933

ABIN412287 产品详细信息, 供应商: Log in to see
Functional Studies (Func), Cell Culture (CC), Blocking Reagent (BR), Inhibition Assay (InhA)
Log in to see
Supplier Product No.
Log in to see
原理 An ATM kinase inhibitor
产品特性 A potent, selective and ATP-competitive inhibitor of Atm Kinase (Ki = 2.2 nM, IC50 = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC50 = 2500, 9300, 16600, >100000 and >100000 nM, respectively).
纯度 ≥ 97 % by HPLC
Chemical Name 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933
Formula C₂₁H₁₇NO₃S₂
Permeability Cell-permeable
Solubility DMSO (100 mM) and Ethanol (50 mM)
分子量 395.49 g/mol
CAS-编号 587871-26-9
限制 仅限研究用
状态 Solid
注意事项 Protect from air and light
储存条件 -20 °C
有效期 24 months
 image for ATM Kinase Inhibitor, KU-55933 (ABIN412287) ATM Kinase Inhibitor, KU-55933
有引用在: DeLoughery, Luczak, Ortega-Atienza, Zhitkovich: "DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 54-63, 2014 (PubMed).