ABIN412090 产品详细信息, 供应商: Log in to see
Blocking Reagent (BR), Inhibition Assay (InhA)
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原理 A pan-caspase inhibitor
序列 Quinolyl-Val-Asp-OPh
产品特性 A synthetic peptide that is potent, cell permeable, nontoxic and irreversibly inhibits caspase activity to blocks apoptosis. The new generation of caspase inhibitor is more stable in aqueous environment and exhibits several folds higher activity than the corresponding FMK caspase inhibitors. Q-VD-OPH is the inhibitor of choice for both in vitro and in vivo studies.
Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.
纯度 > 95 % by HPLC
Chemical Name Q-Val-Asp-Oph, Q-VD-Oph
Formula C₂₆H₂₅F₂N₃O₆
Permeability Cell-permeable
Solubility DMSO
分子量 513.49 g/mol
应用备注 We recommend using 1-10 µM concentration for in vitro enzyme kinetics studies. For in vivo usage, quantity needs to be determined by researcher. 20 mg/Kg of body weight is a proper place to start.
限制 仅限研究用
状态 Solid, Lyophilized
注意事项 Protect from light and moisture
储存条件 -20 °C
有效期 12 months
 image for Q-VD-OPh (ABIN412090) Q-VD-OPh
有引用在: Feng, Langereis, Lork, Nguyen, Hato, Lanke, Emdad, Bhoopathi, Fisher, Lloyd, van Kuppeveld: "Enterovirus 2Apro targets MDA5 and MAVS in infected cells." in: Journal of virology, Vol. 88, Issue 6, pp. 3369-78, 2014 (PubMed).

Quick, Leser, Clarke, Tyler: "Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection." in: Journal of virology, Vol. 88, Issue 22, pp. 13005-14, 2014 (PubMed).

Beck, Niessner, Smalley, Flaherty, Paraiso, Busch, Sinnberg, Vasseur, Iovanna, Drießen, Stork, Wesselborg, Schaller, Biedermann, Bauer, Lasithiotakis, Weide, Eberle, Schittek, Schadendorf, Garbe et al.: "Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells. ..." in: Science signaling, Vol. 6, Issue 260, pp. ra7, 2013 (PubMed).

Frisan, Vandekerckhove, de Thonel, Pierre-Eugène, Sternberg, Arlet, Floquet, Gyan, Kosmider, Dreyfus, Gabet, Courtois, Vyas, Ribeil, Zermati, Lacombe, Mayeux, Solary, Garrido, Hermine, Fontenay: "Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes." in: Blood, Vol. 119, Issue 6, pp. 1532-42, 2012 (PubMed).

Höglund, Nilsson, Muralidharan, Hasvold, Merta, Rudelius, Nikolova, Keller, Nilsson: "Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 22, pp. 7067-79, 2011 (PubMed).

Novgorodov, Chudakova, Wheeler, Bielawski, Kindy, Obeid, Gudz: "Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4644-58, 2011 (PubMed).

Rana, Gupta, Gomez, Matsuyama, Chakrabarti, Agarwal, Agarwal, Agarwal, Wald: "Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 6, pp. 2126-34, 2010 (PubMed).

Yamanouchi, Morgan, Kato, Lengfeld, Zhang, Liu: "Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 4, pp. 702-7, 2010 (PubMed).

Höglund, Nilsson, Forshell, Maclean, Nilsson: "Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine." in: Blood, Vol. 113, Issue 18, pp. 4281-8, 2009 (PubMed).