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CX5461

InhA, Func 1138549-36-6

产品编号 ABIN3220466

发货至: 中国

Datasheet as PDF

应用范围

Inhibition Assay (InhA), Functional Studies (Func)

原理

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

产品特性

Target: DNA/RNA Synthesis inhibitor
Receptor: A375,MIA PaCa-2

纯化方法

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

纯度

98 %

Formula

C27H27N7O2S

Solubility

10 mM in DMSO
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Resveratrol
Act 501-36-0 3,4',5-Trihydroxy-trans-stilbene

Panobinostat
Inh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide

HPA (Hexyl-4-pentynoic acid)
Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Daminozide
Inh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid

Mithramycin A
Inh 18378-89-7

Piceatannol
Inh 10083-24-6 3,3',4,5'-Tetrahydroxy-trans-stilbene

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Solid

储存条件

-20 °C

储存方法

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

有效期

24 months
背景

DNA Damage/DNA Repair

分子量

513.61 g/mol

CAS-编号

1138549-36-6