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抗Mouse (Murine) INHBA 抗体:
抗Rat (Rattus) INHBA 抗体:
抗Human INHBA 抗体:
Human Polyclonal INHBA Primary Antibody for BP, ELISA - ABIN258868
Sallustio, Costantino, Cox, Loverre, Divella, Rizzi, Schena: Human renal stem/progenitor cells repair tubular epithelial cell injury through TLR2-driven inhibin-A and microvesicle-shuttled decorin. in Kidney international 2013
Show all 3 Pubmed References
Human Polyclonal INHBA Primary Antibody for IHC, IHC (p) - ABIN4325951
Howley, Hussey, Link, Howe: Translational regulation of inhibin ?A by TGF? via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells. in Oncogene 2015
Cow (Bovine) Polyclonal INHBA Primary Antibody for WB - ABIN2785821
Ndiaye, Castonguay, Benoit, Silversides, Lussier: Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cells. in Journal of ovarian research 2016
The present study demonstrated that EGF (显示 EGF 抗体) controlled expression of three activin (显示 Actbeta 抗体) subunits (inhbaa, inhbab and inhbb (显示 INHBB 抗体)) in the follicle cells via diverse signaling pathways.
the hCG (显示 CGA 抗体)-stimulated activin (显示 Actbeta 抗体) betaA expression is dependent on the activation of the cAMP-PKA pathway
Activin (显示 Actbeta 抗体) betaA is involved in promoting ovary and follicle growth, whereas activin betaB (显示 INHBB 抗体) may have a tonic role throughout follicle development but becomes critical at the late stage of oocyte maturation and/or ovulation.
Activin (显示 Actbeta 抗体) signaling through SMAD2 (显示 SMAD2 抗体)/3 in retinal progenitor cells regulates expression of transcription factors involved in cell type determination and promotes photoreceptor lineage specification.
Our study provided experimental and clinical evidence for the involvement of activin A and ALK4 (显示 ACVR1B 抗体) in the pathophysiology of atrial fibrosis and atrial fibrillation
binding of SMAD2 (显示 SMAD2 抗体)/3, the intracellular effectors of activin (显示 Actbeta 抗体) signaling, was significantly enriched at the Pmepa1 (显示 PMEPA1 抗体) gene, which encodes a negative feedback regulator of TGF-beta (显示 TGFB1 抗体) signaling in cancer cells, and at the Kdm6b (显示 Kdm6b 抗体) gene, which encodes an epigenetic regulator promoting transcriptional plasticity.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin (显示 Actbeta 抗体) activity, rather than hormonal dysregulation.
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (显示 TPM1 抗体), as a model of immature Leydig cells.
ENPP2 (显示 ENPP2 抗体) links Activin-A enhanced mTOR (显示 FRAP1 抗体) signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
Mice with elevated levels of IL6 (显示 IL6 抗体) exhibited 8.1% weight loss after 9 weeks, whereas mice with elevated levels of activin A lost 11% of their body weight
a conserved role for activin (显示 Actbeta 抗体) in enhancing adipokinetic hormone/glucagon (显示 GCG 抗体) signaling and glycemic control, is reported.
Results indicate that activin (显示 Actbeta 抗体) betaA has an important role outside of reproduction and development, specifically in digestion.
Activin A protects midbrain neurons in the 6-hydroxydopamine mouse model of Parkinson's disease.
pro-activin A share features seen in the pro-TGF-beta1 (显示 TGFB1 抗体) and pro-BMP-9 (显示 GDF2 抗体) structures.
Data suggest that activin A (INHBA) plays roles in inflammation, tissue repair, fibrosis, neoplastic activation of myofibroblasts, and leiomyoma development/growth. [REVIEW]
that high expression of INHBA was associated with poor response to therapy for de novo AML (显示 RUNX1 抗体), and it can serve as an adverse prognostic factor for this malignancy.
Activin-A may induce fibrosis in NASH (显示 SAMSN1 抗体) and alcoholic cirrhosis via activation of Kupffer cells to express pro-inflammatory molecules that promote HSC (显示 FUT1 抗体)-dependent fibrogenesis and could be a target for future anti-fibrotic therapies.
INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1.
Inhibin-B secretion and FSH (显示 BRD2 抗体) isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. (Review)
The present study was undertaken to evaluate the distribution of the FSHB (显示 FSHB 抗体) -211 G/T in men with normal or abnormal sperm parameters from Southern Italy to assess its functional relevance on the serum levels of reproductive hormones and on sperm parameters in men.
analysis of a novel SMAD (显示 SMAD1 抗体)-independent pathway linking enhanced activin B (显示 Actbeta 抗体) signaling to reduced E-cadherin (显示 CDH1 抗体) expression and increased migration in type II endometrial cancer
Results confirm the prodevelopmental actions of activin A and indicate that CTGF (显示 CTGF 抗体) may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF (显示 HGF 抗体) were inhibitory to development.
The expression of the components of the activin (显示 Actbeta 抗体)-inhibin-follistatin (显示 FST 抗体) system is altered in bovine cystic ovarian disease.
Results support a physiological role for granulosa-derived inhibin as an antagonist of bone morphogenetic protein action on thecal androgen synthesis.
activin (显示 Actbeta 抗体) AB is a lignd for activin type IB receptor (显示 ACVR1B 抗体) ALK7 (显示 ACVR1C 抗体) and is responsible for activin (显示 Actbeta 抗体)-mediated secretion of insulin (显示 INS 抗体) from pancreatic beta cell line, MIN6.
An increased expression of Inhibin-beta A was found in oocytes collected from large and medium follicles compared with small follicles before or after in oocyte vitro maturation.
INHA (显示 INHA 抗体) and INHB expression and cellular localization in porcine oocytes were studied.
results indicated that boar testis produces inhibin A and inhibin B during the infantile period but inhibin A is the predominant form towards puberty and molecular weight forms of inhibin and the sites of production change with testicular development
This is the first report on INHBA as an associated candidate gene with the LSM of stallions and the paternal and embryonic component of BVs for the pregnancy rate per oestrus.
The result showed that AA genotype had remarkable litter size at P1 locus in the three goat breeds (P < 0.05). Therefore, these results suggest that INHA (显示 INHA 抗体) gene is a strong candidate gene that affects litter size in goats.
Sequence comparison showed that three base changes in INHA (显示 INHA 抗体)(two amino acid substitutions), and three base changes in INHBA,(one amino acid substitution). No difference seen in INHA (显示 INHA 抗体) or INHBA mRNA expression level in the follicle of the two goat breeds.
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
inhibin, beta A
, activin beta A
, activin beta A1
, inhibin beta A
, inhibin, beta A (activin A, activin AB alpha polypeptide)
, activin A
, inhibin beta A chain-like
, activin beta-A chain
, inhibin beta A chain
, FSH-releasing protein
, Inhibin, beta-1
, erythroid differentiation factor
, erythroid differentiation protein
, follicle-stimulating hormone-releasing protein
, inhibin beta-subunit
, inhibin beta A subunit
, inhibin beta-A-subunit