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ADM was an upstream molecule of HIF-1alpha (显示 HIF1A 蛋白)/VEGF (显示 VEGFA 蛋白) and it promoted angiogenesis through upregulating HIF-1alpha (显示 HIF1A 蛋白)/VEGF (显示 VEGFA 蛋白) in epithelial ovarian cancer.
Identifying a marker(adrenomedullin) for pancreatic cancer among high-risk patients such as new-onset diabetics might lead to the identification of a subpopulation needing to be screened in order to enable early diagnosis and treatment of a highly lethal tumor
High ADM expression is associated with lymph node metastasis in oral and oropharyngeal squamous cell carcinoma.
High expression of ADM is correlated with sunitinib-resistant renal cell carcinoma (显示 MOK 蛋白).
results indicate a novel function of adrenomedullin (ADM) in pancreatic ductal adenocarcinoma (PDAC), and suggest ADM is a promising target in the treatment of PDAC.
These results indicate that elevated ADM may be involved in the etiology of schizophrenia through the regulation of heat shock protein signaling.
our results pointed towards two MR-pro-ADM threshold values that appear to predict with a good degree of accuracy the patient's need for non-invasive mechanical ventilation, endotracheal intubation, or intensive care. This aspect, however, deserves further investigation
MR-proADM but not copeptin (显示 AVP 蛋白) was significantly associated with prognosis of COPD (显示 ARCN1 蛋白) exacerbations at 30 days.
Findings indicate the importance of cancer-associated fibroblasts (CAFs (显示 TBX1 蛋白))-derived adrenomedullin (AM) pathway in growth of breast carcinoma and in neovascularization by supplying and amplifying signals that are essential for pathologic angiogenesis.
Mouse and human heart valves expressed mRNAs for the CRL (显示 IL31RA 蛋白) ligands adrenomedullin (AM), adrenomedullin-2 (AM-2 (显示 ADM2 蛋白)) and calcitonin gene-related peptide (CGRP (显示 CALCA 蛋白)) and for their receptor components, i.e., CRL (显示 IL31RA 蛋白) and receptor-activity-modifying proteins 1-3.
The AM-RAMP2 (显示 RAMP2 蛋白) system exerts crucial vasoprotective effects after vascular injury and could be a therapeutic target for the treatment of vascular diseases.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2 (显示 ADM2 蛋白)) and calcitonin gene-related peptide (CGRP (显示 CALCA 蛋白)) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
Findings demonstrated that Adrenomedullin (AM) was produced by synovial fibroblasts and macrophages in inflamed synovial tissue and that increased levels of AM may exert anti-inflammatory effects on synovial macrophages.
vascular dysfunction was potentially augmented by a decrease in production of the pulmonary vasodilator adrenomedullin
It was concluded that ADM may regulate chloride and fluid secretion from the seminal vesicle, which may affect the composition of the seminal plasma bathing the sperm and, hence, fertility.
Estrogen-induced microRNAs are important for balancing cardiac Adm expression in female mice.
These results indicate the AM-RAMP2 (显示 RAMP2 蛋白) system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth.
Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.
The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase (显示 NOX1 蛋白) probably by suppressing the local renin (显示 REN 蛋白)-angiotensin system.
Hypoxia upregulates expression of the Notch ligand Dll4 (显示 DLL4 蛋白) and increases Notch (显示 NOTCH1 蛋白) signaling in a process requiring the vasoactive hormone adrenomedullin.
Studied adrenomedullin's (ADM) role in oviductal fluid flow in cattle.
Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR (显示 CALCRL 蛋白), RAMP2 (显示 RAMP2 蛋白) and RAMP3 (显示 RAMP3 蛋白) were detected in cotyledonary villous and caruncular epithelial cells.
The present study thus showed that neither leptin (显示 LEP 蛋白) nor resistin (显示 RETN 蛋白) affects the expression of endothelin-1 (显示 EDN1 蛋白) or adrenomedullin in bovine brain microvascular endothelial cells.
Data suggest that ADM (adrenomedullin) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (显示 CALCRL 蛋白) (calcitonin gene-related peptide (显示 CALCA 蛋白) receptor; not adrenomedullin receptor (显示 GPR182 蛋白)).
adrenomedullin prevented loss of cerebral autoregulation after fluid percussion injury in a sex-dependent and ERK MAPK (显示 MAPK1 蛋白)-dependent manner
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element.