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Cow (Bovine) Polyclonal ABCC2 Primary Antibody for WB - ABIN610784
Cockcroft, Thomas, Fensome, Geny, Cunningham, Gout, Hiles, Totty, Truong, Hsuan: Phospholipase D: a downstream effector of ARF in granulocytes. in Science (New York, N.Y.) 1994
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
ATP-binding cassette sub-family C member 2
, canalicular multidrug resistance protein
, canalicular multispecific organic anion transporter 1
, multidrug resistance-associated protein 2
, multidrug resistance protein 2
, ATP-binding cassette, sub-family C (CFTR/MRP), member 2
, calicular multispecific organic anion transporter
, multidrug resistance associated protein 2