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Ovarian expression of relaxin-3a, d and f genes, and the relaxin-3 receptor gene Rxfp3, was studied in Danio rerio.
pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish
we report the expression pattern of the duplicated zebrafish rln3b gene and compare it to the previously analyszd spatial expression pattern of the rln3a gene
Serum level of relaxin-3 hormone is an important mediator in the pathophysiological process of normal puberty being significantly decreased in males with delayed puberty.
Therefore, we conclude that stapling of the relaxin3 B chain does not compromise its ability to activate RXFP3 and is a promising method for developing stable peptide agonists and antagonists of RXFP3 to aid relaxin-3/RXFP3 research.
the relaxin-3 B-chain C-terminus changes from the original folding-back conformation to an extended conformation during binding with RXFP3, to allow its B27Trp and B26Arg residues to interact with the Trp138 and Glu141 residues of RXFP3, respectively.
In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting.
the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3
Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5.
Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Review of research depicts the connection of relaxin-3 with phenomena such as feeding behavior, spatial memory, sleep/wake cycle or modulation of pituitary gland hormone secretion.
we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor
Glu141 and Asp145 of the RXFP3 interact with the highly conserved arginine residues of relaxin-3.
Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4.
Relaxin-2 or relaxin-3 levels are not related to component traits in patients with diabetes.
metabolic syndrome is associated with increased serum relaxin-3 levels in women
[review] Relaxin-3 (RXF3P) is expressed within GABA neurons of the brainstem including an area known as the nucleus incertus; ascending relaxin-3 projections innervate a broad range of RXFP3-rich forebrain areas.
H3 relaxin exerts antifibrotic actions via RXFP1 receptor
Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues.
relaxin-3/INSL7 is a ligand for GPCR142
GPCR135 is the receptor for relaxin-3
RLN3 chimeric peptide is a potential tool to study in vivo function of GPCR135.
Intracerebroventricular injections of human relaxin-3 (H3) to satiated rats significantly increased food intake.
Results indicate endogenous RLN3/RXFP3 signaling can modulate hippocampal-dependent spatial reference and working memory via effects on somatostatin interneurons, and further our knowledge of hippocampal cognitive processing
That endogenous relaxin-3-RXFP3 signalling is a powerful mediator of salt appetite in mice.
The present study compared the ability of relaxin-3 deficient (null mutation) and C57BL/6J wildtype littermate mice to entrain daily running wheel activity to timed food availability.
These findings are consistent with an earlier report of increased activity scores in rats acutely injected centrally with R3/I5, and further suggest a role for relaxin-3/RXFP3 signalling in promoting behavioural arousal.
These preliminary studies suggest an interaction between relaxin-3 and ventrolateral preoptic galanin neurons that may contribute to the arousal-promoting action of relaxin-3.
Central injection of the RXFP3 agonists R3/I5 or H3 relaxin (0.5 nmol, icv) did not alter chow consumption in satiated mice relative to vehicle controls, during the 60 min after treatment.
Relaxin-3 knockout mice exhibit mild anxiolytic characteristics relative to wild-type mice, suggesting that this peptide is involved in anxiety-related behavior.
These studies support a role for relaxin-3 signaling in the control of arousal and sleep/wakefulness, and identify the relaxin-3 KO mouse as a useful model to study this role further.
Data provide evidence for the conserved nature of RLN3/RXFP3 systems in mammalian brain and the ability of RLN3/RXFP3 signaling to modulate "behavioral state" and an array of circuits involved in arousal, stress, affect, and cognition.
results indicate that relaxin 3 transcription is activated via the cAMP-PKA pathway in the downstream of CRF-R1
The findings support the hypothesis that relaxin-3 signaling contributes to the central control of arousal, exploratory behavior and stress responses.
May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).
relaxin-like peptide locus B
, relaxin 3
, relaxin family locus C type 2
, relaxin family locus C type I
, insulin-like 7
, insulin-like peptide 7
, insulin-like peptide INSL7
, prorelaxin H3
, prorelaxin M3
, prorelaxin R3
, Prorelaxin H3